Diazoxide (Hyperstat)

06/01/1983 - "[Infant idiopathic hypoglycemia treated successfully with diazoxide]."
08/01/2015 - "Diazoxide therapy was effective for the hypoglycemia. "
04/01/2014 - "She responded well, but the hypoglycemia returned after reducing the diazoxide. "
04/01/1997 - "All five patients had documented hypoglycemia, and all responded well to diazoxide. "
06/01/2015 - "A randomized, double-blind, placebo-controlled cross-over trial using a stepped hyperinsulinemic hypoglycemia clamp was performed in 12 T1D subjects with prior ingestion of diazoxide (7 mg/kg) or placebo. "

11/01/2005 - "Tarlov's score outcomes showed a marked improvement in the diazoxide group, in the KR20 group, and in the KR50 group compared to the ischemia group (p = .005, .002, and .001, respectively). "
01/01/2010 - "Finally, in isolated rat hearts, preconditioning with diazoxide prior to global ischemia significantly improved left ventricular function and attenuated hypercontracture during reperfusion. "
05/01/2004 - "After ischemia and reperfusion (I/R), the two groups that were treated by diazoxide only (Groups II and IV) had a significant improvement in LVDP, +/-dp/dtmax, and CF recovery. "
04/27/2001 - "After 20 minutes of global ischemia and 20 minutes of reflow, hearts perfused with 100 micromol/L diazoxide before ischemia showed significantly improved postischemic contractile function relative to untreated hearts (84% versus 29% of initial left ventricular developed pressure, respectively). "
02/26/2008 - "To study the protective mechanism of ischemic preconditioning (IPC) and diazoxide preconditioning (DPC) against myocardium ischemia-reperfusion (I/R) injury. "

01/01/1981 - "Our study has shown that pulse administration of diazoxide is effective in reducing blood pressure in these patients with severe, uncontrolled hypertension. "
11/01/1979 - "Repeated use of diazoxide for subsequent recurrence of severe hypertension was equally effective and safe in 93 per cent of the instances. "
08/01/1963 - "CLINICAL EVALUATION OF DIAZOXIDE: A NEW TREATMENT FOR ACUTE HYPERTENSION."
11/01/1979 - "The safety and efficacy of diazoxide administered intravenously in the treatment of children with acute severe hypertension have been evaluated by a collaborative study. "
03/01/1982 - "Efficacy of slow infusion of diazoxide in the treatment of severe hypertension without organ hypoperfusion."

10/01/2003 - "Diazoxide and controlled reperfusion improved intra-myocyte Na(+) homeostasis after severe ischemia-reperfusion injury."
10/01/2003 - "This study determines whether controlled reperfusion or diazoxide improves intramyocyte Na(+) homeostasis using a porcine model of severe ischemia-reperfusion injury. "
11/07/2014 - "Diazoxide maintains liver mitochondrial function, increases liver tolerance to ischemia/reperfusion injury, and reduces the systemic inflammatory response. "
11/07/2014 - "To investigate the effect of diazoxide administration on liver ischemia/reperfusion injury. "
07/01/2006 - "Age- and gender-related differences in ischemia/reperfusion injury and cardioprotection: effects of diazoxide."

08/01/1998 - "We reviewed 77 cases of primary persistent hyperinsulinism in neonates and infants who were treated with diazoxide and studied criteria predictive of therapeutic efficacy. "
01/01/2008 - "Linear regression assay demonstrated a close correlation between decreasing hyperinsulinemia and the protective effects of diazoxide. "
09/01/2014 - "Recessive mutations of these genes cause hyperinsulinism that is unresponsive to treatment with channel agonists like diazoxide. "
06/01/2013 - "Fifteen Japanese patients with diazoxide-unresponsive, KATP-channel hyperinsulinism. "
10/01/2012 - "Case 2 was diagnosed with diazoxide-responsive hyperinsulinism at 3 months of age and had complete resolution of hyperinsulinism by 4 yr. She was found to have a novel MODY3 HNF1A missense mutation, also carried by her father. "