Diazoxide (Hyperstat)

06/01/1983 - "[Infant idiopathic hypoglycemia treated successfully with diazoxide]."
10/01/2020 - "Diazoxide is a benzothiadiazine that can be effective in managing hypoglycemia in frail patients with surgical risk. "
10/06/2023 - "When he began diazoxide treatment, the reactive hypoglycemia improved. "
01/01/2021 - "The patient's hypoglycemia improved with oral diazoxide. "
09/18/2020 - "Diazoxide may help to improve hyperinsulinemic hypoglycemia. "

11/01/2005 - "Tarlov's score outcomes showed a marked improvement in the diazoxide group, in the KR20 group, and in the KR50 group compared to the ischemia group (p = .005, .002, and .001, respectively). "
01/01/2010 - "Finally, in isolated rat hearts, preconditioning with diazoxide prior to global ischemia significantly improved left ventricular function and attenuated hypercontracture during reperfusion. "
05/01/2004 - "After ischemia and reperfusion (I/R), the two groups that were treated by diazoxide only (Groups II and IV) had a significant improvement in LVDP, +/-dp/dtmax, and CF recovery. "
04/27/2001 - "After 20 minutes of global ischemia and 20 minutes of reflow, hearts perfused with 100 micromol/L diazoxide before ischemia showed significantly improved postischemic contractile function relative to untreated hearts (84% versus 29% of initial left ventricular developed pressure, respectively). "
01/01/2018 - "The aim of this study is to determine whether diazoxide can provide protection in a rat model of intestinal ischemia reperfusion. "

01/01/1981 - "Our study has shown that pulse administration of diazoxide is effective in reducing blood pressure in these patients with severe, uncontrolled hypertension. "
11/01/1979 - "Repeated use of diazoxide for subsequent recurrence of severe hypertension was equally effective and safe in 93 per cent of the instances. "
02/01/1976 - "A new technique for safe and effective control of hypertension with intravenous diazoxide."
08/01/1963 - "CLINICAL EVALUATION OF DIAZOXIDE: A NEW TREATMENT FOR ACUTE HYPERTENSION."
11/01/1979 - "The safety and efficacy of diazoxide administered intravenously in the treatment of children with acute severe hypertension have been evaluated by a collaborative study. "

08/01/1998 - "We reviewed 77 cases of primary persistent hyperinsulinism in neonates and infants who were treated with diazoxide and studied criteria predictive of therapeutic efficacy. "
01/01/2008 - "Linear regression assay demonstrated a close correlation between decreasing hyperinsulinemia and the protective effects of diazoxide. "
10/30/2021 - "In this study, 86% born large for gestation and 78% born appropriate for gestation and who did not respond to diazoxide treatment had KATP-hyperinsulinism. "
04/19/2023 - "Whole exome sequencing was performed to investigate for diazoxide-unresponsive hyperinsulinism, which revealed a likely pathogenic mutation in the INSR gene c.1246C>T p. "
01/01/2022 - "However, treatment options for children with nonfocal diazoxide-unresponsive hyperinsulinism have continued to be limited. "

01/01/2023 - "There was a significant reduction in infarct size (22% ± 11% of area at risk with diazoxide pretreatment vs. 47% ± 11% with placebo) and area of no-reflow (14% ± 14% of infarct size with diazoxide pretreatment vs. 46% ± 20% with placebo). "
04/01/2010 - "In a separate series of experiments, both ischaemic (4 cycles of 3.5 min of ischaemia and 5 min of reperfusion) and pharmacological (50 micromol l(-1) diazoxide, 10 min) preconditioning reduced infarct size in hearts from wild-type mice (by 24.84 and 26.63%, respectively, P < 0.05), but only ischaemic preconditioning was effective in hearts from heterozygous animals and both preconditioning strategies failed to protect Cx43KI32 homozygous hearts. "
01/01/2023 - "Diazoxide is a powerful cardioprotectant but is not feasible in a realistic infarct scenario."
08/01/2011 - "Remodeling in response to CHF and/or previous infarct potentiated diazoxide-induced APD shortening. "
02/23/2011 - "The administration of diazoxide resulted in a 60% in infarct size. "