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Dianhydrogalactitol

One of the cytotoxic dihalohexitols that alkylates and cross-links DNA via an epoxide group during all phases of the cell cycle, resulting in a disruption of DNA function and cell cycle arrest. It has antineoplastic activity and also causes bone marrow toxicity.
Also Known As:
1,2,5,6-Dianhydrogalactitol; 1,2-5,6-Dianhydrogalactitol; NSC-132313; NSC 132313; NSC132313; Dianhydrodulcitol; Diepoxydulcitol; Diepoxygalactitol; Galactitol, 1,2:5,6-dianhydro-
Networked: 75 relevant articles (1 outcomes, 23 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Brown, Dennis: 3 articles (12/2020 - 10/2018)
2. Bacha, Jeffrey: 2 articles (01/2020 - 10/2018)
3. Daugaard, Mads: 2 articles (01/2020 - 10/2018)
4. Steinø, Anne: 2 articles (01/2020 - 10/2018)
5. Zhai, Beibei: 2 articles (01/2020 - 10/2018)
6. Covarrubias, Claudia: 1 article (07/2021)
7. Fiani, Brian: 1 article (07/2021)
8. Jarrah, Ryan: 1 article (07/2021)
9. Onyedimma, Chiduziem: 1 article (07/2021)
10. Al-Shahrour, Fátima: 1 article (01/2021)

Related Diseases

1. Glioblastoma (Glioblastoma Multiforme)
2. Neoplasms (Cancer)
3. Lung Neoplasms (Lung Cancer)
4. Melanoma (Melanoma, Malignant)
5. Adenocarcinoma

Related Drugs and Biologics

1. Alkylating Agents
2. Dianhydrogalactitol
3. Doxorubicin (Adriamycin)
4. Cisplatin (Platino)
5. Razoxane
6. Cyclophosphamide (Cytoxan)
7. Mitolactol
8. Megestrol Acetate (Borea)
9. Altretamine (Hemel)
10. beta-2'-deoxythioguanosine

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Therapeutics
3. Combination Drug Therapy (Combination Chemotherapy)
4. Remission Induction
5. Radiotherapy