Lipoatrophic Diabetes Mellitus

A type of diabetes mellitus that is characterized by severe INSULIN RESISTANCE and LIPODYSTROPHY. The latter may be generalized, partial, acquired, or congenital (LIPODYSTROPHY, CONGENITAL GENERALIZED).

Also Known As:

Networked: 8 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Type 2 Diabetes Mellitus (MODY)
2.	Insulin Resistance
3.	Diabetes Mellitus

Experts

1.	Sano, R: 1 article (11/2001)
2.	Shimada, F: 1 article (11/2001)
3.	Makino, H: 1 article (11/2001)
4.	Saito, Y: 1 article (11/2001)
5.	Hashimoto, N: 1 article (11/2001)
6.	Taira, M: 1 article (11/2001)
7.	Miki, T: 1 article (11/2001)
8.	Suzuki, Y: 1 article (11/2001)
9.	Kanatsuka, A: 1 article (11/2001)
10.	Panz, V R: 1 article (07/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Lipoatrophic Diabetes Mellitus:

1.	Glucose (Dextrose)FDA LinkGeneric 03/01/1997 - "Improved glucose tolerance after effective lipid-lowering therapy with bezafibrate in a patient with lipoatrophic diabetes mellitus: a putative role for Randle's cycle in its pathogenesis?"
2.	BezafibrateIBA 03/01/1997 - "Improved glucose tolerance after effective lipid-lowering therapy with bezafibrate in a patient with lipoatrophic diabetes mellitus: a putative role for Randle's cycle in its pathogenesis?"
3.	AntibodiesIBA 01/01/1998 - "In an effort to identify the pathogenetic mechanisms of lipoatrophic diabetes mellitus in this patient and to develop a therapeutic strategy, antibodies against different tissues and endocrinologic regulation were investigated. " 07/01/2000 - "This study investigated the association between glutamic acid decarboxylase antibodies (GAD-AB) and Type 1, Type 2, pancreatic and lipoatrophic diabetes mellitus (DM) in South African patients. "
4.	Insulin Receptor Substrate ProteinsIBA 11/01/1997 - "Insulin receptor substrate-1 gene variants in lipoatrophic diabetes mellitus and non-insulin-dependent diabetes mellitus: a study of South African black and white subjects."
5.	Glutamate Decarboxylase (Decarboxylase, Glutamate)IBA 07/01/2000 - "This study investigated the association between glutamic acid decarboxylase antibodies (GAD-AB) and Type 1, Type 2, pancreatic and lipoatrophic diabetes mellitus (DM) in South African patients. "
6.	hydroquinone (Black and White)FDA Link 11/01/1997 - "Insulin receptor substrate-1 gene variants in lipoatrophic diabetes mellitus and non-insulin-dependent diabetes mellitus: a study of South African black and white subjects."
7.	Insulin (Novolin)FDA Link 12/01/1998 - "Lipoatrophic diabetes mellitus treated by continuous subcutaneous insulin infusion." 11/01/1990 - "Lipoatrophic diabetes mellitus is a rare syndrome characterized by lipoatrophy and insulin-resistant diabetes mellitus. " 11/01/2001 - "We screened for mutations in the gene of insulin-sensitive phosphodiesterase 3B (PDE3B), which regulates antilipolytic actions of insulin via reduction of intracellular cyclic AMP levels, in Japanese patients with type 2 diabetes mellitus and lipoatrophic diabetes mellitus using single-stranded conformation polymorphism analysis and Southern analysis and investigated frequencies of variable number of tandem repeats. " 12/01/1988 - "To determine the role of genetic defects in the insulin receptor in the insulin resistance of lipoatrophic diabetes mellitus, we studied insulin binding, insulin receptor autophosphorylation, and insulin receptor mRNA levels and performed Southern blot analysis of genomic DNA in four siblings, all of whom have some degree of insulin resistance and three of whom have lipoatrophy. "
8.	Type 3 Cyclic Nucleotide PhosphodiesterasesIBA 11/01/2001 - "We screened for mutations in the gene of insulin-sensitive phosphodiesterase 3B (PDE3B), which regulates antilipolytic actions of insulin via reduction of intracellular cyclic AMP levels, in Japanese patients with type 2 diabetes mellitus and lipoatrophic diabetes mellitus using single-stranded conformation polymorphism analysis and Southern analysis and investigated frequencies of variable number of tandem repeats. "
9.	Somatomedins (Somatomedin)IBA 01/01/1998 - "Dysregulation of insulin-like growth factors in a case of generalized acquired lipoatrophic diabetes mellitus (Lawrence Syndrome) connected with autoantibodies against adipocyte membranes."
10.	Messenger RNA (mRNA)IBA 12/01/1988 - "To determine the role of genetic defects in the insulin receptor in the insulin resistance of lipoatrophic diabetes mellitus, we studied insulin binding, insulin receptor autophosphorylation, and insulin receptor mRNA levels and performed Southern blot analysis of genomic DNA in four siblings, all of whom have some degree of insulin resistance and three of whom have lipoatrophy. "