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Experimental Diabetes Mellitus

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Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.

Also Known As:

Diabetes Mellitus, Experimental; Diabete, Streptozocin; Diabetes, Alloxan; Diabetes, Streptozocin; Diabetes, Streptozotocin; Streptozocin Diabete; Alloxan Diabetes; Streptozocin Diabetes; Streptozotocin Diabetes

Networked: 1609 relevant articles (37 outcomes, 130 trials/studies)

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Disease Context: Research Results

Related Diseases

1.	Body Weight (Weight, Body)
2.	Inflammation
3.	Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy)
4.	Diabetes Mellitus
5.	Hypoglycemia (Reactive Hypoglycemia)

Experts

1.	Rassokhina, L M: 8 articles (03/2015 - 03/2009)
2.	Patel, Samir P: 7 articles (03/2008 - 01/2006)
3.	Katyare, Surendra S: 7 articles (03/2008 - 01/2006)
4.	Sybirna, N O: 6 articles (07/2015 - 09/2006)
5.	Volchegorskiĭ, I A: 6 articles (01/2014 - 11/2008)
6.	Shpakov, A O: 5 articles (03/2015 - 01/2005)
7.	Brodiak, I V: 5 articles (01/2014 - 09/2006)
8.	Vallon, Volker: 5 articles (01/2014 - 01/2002)
9.	Miroshnichenko, I Iu: 5 articles (01/2014 - 03/2009)
10.	Prysiazhna, O D: 5 articles (01/2008 - 01/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Experimental Diabetes Mellitus:

1.	Insulin (Novolin)FDA Link 02/01/1983 - "Induction of streptozotocin-diabetes in rats weighing 200 g resulted in a marked decrease in the insulin responsiveness of fat cells. " 02/01/1982 - "Insulin treatment improves the spontaneous remission of neonatal streptozotocin diabetes in the rat." 01/01/2005 - "Effects of streptozotocin-diabetes and insulin replacement on the epididymis of prepubertal rats: histological and histomorphometric studies." 07/01/1999 - "To ascertain the glomerular hemodynamic basis for this effect of ACEI, micropuncture studies were performed in male Wistar-Froemter rats after 5 to 6 wk of insulin-treated streptozotocin diabetes. " 07/01/1997 - "In the present study we examined the converse condition by testing the effects of chronic salt loading on kidney function in moderately hyperglycemic insulin-treated rats with early and established streptozotocin diabetes. "
2.	Glucose (Dextrose)FDA LinkGeneric 11/01/1981 - "The present study suggests that although streptozotocin diabetes alters plasma-ocular glucose transport, there is no direct impairment of glucose carrier function. " 03/01/2011 - "Neurochemical correlates of alloxan diabetes: glucose and related brain metabolism in the rat." 07/01/2003 - "Brown adipose tissue (BAT) glyceroneogenesis was evaluated in rats either fasted for 48 h or with streptozotocin-diabetes induced 3 days previously or adapted for 20 days to a high-protein, carbohydrate-free (HP) diet, conditions in which BAT glucose utilization is reduced. " 07/01/1997 - "Maternal semistarvation and streptozotocin-diabetes in rats have different effects on the in vivo glucose uptake by peripheral tissues in their female adult offspring." 11/01/1995 - "[Level of glucose in blood, gas exchange, and hematologic indicators of rats with experimental diabetes mellitus after carotid glomectomy]."
3.	AlloxanIBA 01/01/1995 - "Protection against alloxan diabetes by low-dose 60Co gamma irradiation before alloxan administration." 05/01/1980 - "In starved mice injected with MH before alloxan there was an inhibition of the initial hyperglycaemia, but occurrence of a "second" hyperglycaemia, suggesting an absence of protection against the development of alloxan diabetes. " 07/01/2011 - "Alloxan and oxidative stress, which have been detected in livers of laboratory animals shortly after in vivo alloxan administration, cause in vitro mitochondrial dysfunction, thus questioning alloxan diabetes as an acceptable model for type 1 diabetes, a model that cannot legitimately be used to investigate mitochondrial metabolism in a diabetic state. " 09/17/2004 - "Alloxan has been widely used to produce experimental diabetes mellitus syndrome. " 04/01/2002 - "DTZ, 20 mg/kg, was orally administered to control rabbits and rabbits with fifth day (experiment was performed at fifth day after first and second days intravenous administration of alloxan) and 13th day (experiment was performed at 13th day after first, second, sixth, and 10th days intravenous administration of alloxan) diabetes mellitus induced by alloxan. "
4.	Blood Glucose (Blood Sugar)IBA 05/01/2015 - "An experimental diabetes mellitus model was created in 16 rats, and eight rats with normal blood glucose levels were included in control group (Group-1). " 01/01/2006 - "Transcranial stimulation normalizes blood sugar levels in alloxan diabetes in rats." 05/01/1980 - "The data show that alloxan diabetes may develop in the absence of an "initial" hyperglycaemia and a triphase blood glucose response. " 03/01/1956 - "Alloxan diabetes in the hamster: dosage and blood sugar curves." 02/01/2007 - "Exposure of rats with experimental diabetes mellitus to wide-band electromagnetic radiation generated by He-Ne laser and modulated by the pancreas and spleen is informing and phenomenological method prolonging animal life span, normalizing blood glucose level, and promoting regeneration of the pancreas."
5.	DNA (Deoxyribonucleic Acid)IBA 01/01/1994 - "Comparative analysis of serum DNA content in healthy rats, rats with experimental alloxan diabetes, and the rats with the diabetes compensated by transplantation of the embryonal pancreas into the anterior chamber of the eye. " 12/01/2000 - "Alkylation of DNA leads to necrosis of pancreatic beta cells and thus to a state of insulin-dependent diabetes mellitus, well-known as streptozotocin diabetes in experimental diabetes research." 05/05/2000 - "Comparison of therapeutic regimens in the amelioration of alterations in rat gastrointestinal mucosal DNA, RNA and protein induced by streptozotocin diabetes mellitus." 12/25/2003 - "Intramuscular injection of naked plasmid DNA encoding human preproinsulin gene in streptozotocin-diabetes mice results in a significant reduction of blood glucose level." 05/05/2000 - "The current study has two main foci 1) to monitor the alterations in gastrointestinal DNA, RNA and protein content induced by streptozotocin diabetes and 2) to use these parameters to monitor the efficacy of intensive insulin treatment versus pancreatic islet transplantation in the amelioration of the diabetes induced alterations. "
6.	Glutathione (Reduced Glutathione)IBA 04/01/1946 - "Protective effects of glutathione and cysteine against alloxan diabetes in the rat." 09/17/1948 - "The Mechanism of Cysteine and Glutathione Protection Against Alloxan Diabetes." 06/01/1999 - "The root extract also causes an increase in the levels of glutathione and vitamin C in alloxan diabetes. " 01/01/1955 - "I. Effect of administration of different sugars on blood glutathione and its relation to the incidence of experimental (alloxan) diabetes." 12/01/1949 - "Sodium and its relation to alloxan diabetes and glutathione."
7.	HexosesIBA 03/25/1955 - "In the article "On the protection against alloxan diabetes by hexoses" by G. " 03/25/1955 - "On the Protection against Alloxan Diabetes by Hexoses." 11/19/1954 - "On the protection against alloxan diabetes by hexoses."
8.	Cysteine (L-Cysteine)FDA Link 04/01/1946 - "Protective effects of glutathione and cysteine against alloxan diabetes in the rat." 09/17/1948 - "The Mechanism of Cysteine and Glutathione Protection Against Alloxan Diabetes."
9.	Streptozocin (Streptozotocin)FDA Link 09/01/2007 - "In this study, we used Streptozotocin for our experiments in induction of experimental diabetes mellitus. " 11/01/1996 - "The purpose of this study was to examine the mechanisms of alterations in cardiac K+ channel function in early stages of experimental diabetes mellitus induced by streptozotocin. " 04/01/1995 - "The present studies examined the effects of streptozotocin induced diabetes on the concentrations of CA-III. The concentration of CA-III in the liver, muscles and serum of rats with experimental diabetes mellitus was measured by the method of enzyme-immunoassay. " 10/01/2014 - "Intra-venous injection of 60 mg/kg dose of streptozotocin in 250-300 g (75-90 days) adult Wistar rats makes pancreas swell and causes degeneration in Langerhans islet β-cells and induces experimental diabetes mellitus in 2-4 days. " 05/01/2013 - "Early experimental diabetes mellitus was induced in rats with streptozotocin or streptozotocin/high fat. "
10.	FructoseIBA 09/01/1974 - "[Effect of fructose administration on liver glycolysis in rate with alloxan diabetes]." 03/24/1972 - "Increased fructose production by the brain in alloxan diabetes." 02/27/1953 - "Protection against alloxan diabetes by mannose and fructose." 01/01/1961 - "[Inclusion of methionine-S35 into liver slices of rats with alloxan diabetes in a medium containing glucose or fructose]." 03/01/1958 - "Studies on the comparative utilization of glucose, fructose and galactose in alloxan-diabetes."

Therapies and Procedures

1.	Transplantation (Transplant Recipients) 01/01/1991 - "Transplantation of the embryonic pancreas to an immune privileged area (the anterior chamber of the eye) ensures considerable improvement of the condition of animals with alloxan diabetes. " 04/01/1982 - "Normal response to pregnancy in rats cured of streptozotocin diabetes by transplantation of one fetal pancreas." 09/01/2001 - "Study of the reversibility of endothelial dysfunction in a rat model of diabetes mellitus: experimental treatment by transplantation of pancreatic islets." 01/01/2014 - "Allogenous skin fibroblast transplantation enhances excisional wound healing following alloxan diabetes in sheep, a randomized controlled trial." 04/01/2012 - "Compensatory function of submandibular gland in mice with streptozotocin diabetes under conditions of transplantation."
2.	Islets of Langerhans Transplantation 03/01/1981 - "To establish the neural mediation of this reflex response we used rats that were cured from streptozotocin diabetes by intrahepatic islet-transplantation as a denervated B-cell preparation. " 01/01/1988 - "Preliminary report on microencapsulated islet transplantation in experimental diabetes mellitus in China." 05/01/1983 - "Hypogastrinemia in streptozotocin diabetes with islet transplantation--reconstitution." 12/01/2001 - "Effects of streptozocin diabetes and diabetes treatment by islet transplantation on in vivo insulin signaling in rat heart." 10/27/2001 - "Homologous islet transplantation was performed in inbred Lewis rats 15 days (TA), 4 months (TB), and 8 months (TC) after streptozotocin diabetes. "
3.	Intramuscular Injections 12/25/2003 - "Intramuscular injection of naked plasmid DNA encoding human preproinsulin gene in streptozotocin-diabetes mice results in a significant reduction of blood glucose level." 11/01/2014 - "Intramuscular injections of the vitamin complex containing: thiamine chloride (B1), riboflavin (B2), lipoic acid (N), calcium pantothenate (B5), pyridoxine hydrochloride (B6), folic acid (B9), ascorbic acid (C) can reduce the blood glucose level in serum of rats with alloxan diabetes, stabilize activity of some enzymes of energy metabolism, lactate dehydrogenase and pyruvate dehydrogenase complex. "
4.	Transplants (Transplant) 03/01/2008 - "Sixty inbred male Lewis rats were assigned to four experimental groups: NC-15 nondiabetic control rats; DC-15 untreated diabetic control rats; PT1-15 diabetic rats that received syngeneic pancreas transplants 2 weeks after alloxan diabetes induction; PT2-15 diabetic rats that received pancreas transplants 12 weeks after diabetes onset. " 03/01/1964 - "[PANCREAS GRAFT IN THE ANTERIOR CHAMBER OF THE EYE OF THE RAT WITH ALLOXAN DIABETES]." 03/01/1964 - "[SUBCONJUNCTIVAL PANCREATIC GRAFT IN A RAT WITH ALLOXAN DIABETES]." 02/01/1988 - "To compare the long-term effectiveness of whole pancreas transplantation and pancreatic islet transplantation in controlling the metabolic disorders of alloxan diabetes, metabolic studies were performed monthly for 2 years in 4 groups of highly inbred rats: (1) NC-116 nondiabetic controls; (2) DC-273 untreated alloxan-diabetic controls; (3) PDT-182 rats that received syngeneic pancreaticoduodenal transplants shortly after induction of diabetes with alloxan; and (4) IT-92 rats that received an intraportal injection of at least 1500, but usually 2000, syngeneic pancreatic islets shortly after induction of diabetes with alloxan. " 09/01/1987 - "To compare the long-term effectiveness of whole pancreas transplantation and pancreatic islet transplantation in controlling the metabolic disorders and preventing the kidney lesions of alloxan diabetes, metabolic and morphologic studies were performed in four groups of rats: (1) NC-116 nondiabetic controls; (2) DC-273 untreated alloxan-diabetic controls; (3) PDT-182 rats that received syngeneic pancreaticoduodenal transplants not long after induction of diabetes with alloxan; and (4) IT-92 rats that received an intraportal injection of at least 1500 and usually 2000 syngeneic pancreatic islets soon after induction of diabetes with alloxan. "
5.	Pancreas Transplantation 07/01/1980 - "Prevention by whole pancreas transplantation of glomerular basement membrane thickening in alloxan diabetes." 03/01/1974 - "Recovery from experimental diabetes mellitus in mice after pancreas transplantation." 04/01/2000 - "In conclusion, in a rat model with streptozotocin-diabetes and pancreas transplantation but no need for immunosuppression, both systemic and portal venous drainage avoid peripheral and hepatic insulin resistance; also, there is no increased risk for atherosclerosis." 02/01/1988 - "To compare the long-term effectiveness of whole pancreas transplantation and pancreatic islet transplantation in controlling the metabolic disorders of alloxan diabetes, metabolic studies were performed monthly for 2 years in 4 groups of highly inbred rats: (1) NC-116 nondiabetic controls; (2) DC-273 untreated alloxan-diabetic controls; (3) PDT-182 rats that received syngeneic pancreaticoduodenal transplants shortly after induction of diabetes with alloxan; and (4) IT-92 rats that received an intraportal injection of at least 1500, but usually 2000, syngeneic pancreatic islets shortly after induction of diabetes with alloxan. " 09/01/1987 - "To compare the long-term effectiveness of whole pancreas transplantation and pancreatic islet transplantation in controlling the metabolic disorders and preventing the kidney lesions of alloxan diabetes, metabolic and morphologic studies were performed in four groups of rats: (1) NC-116 nondiabetic controls; (2) DC-273 untreated alloxan-diabetic controls; (3) PDT-182 rats that received syngeneic pancreaticoduodenal transplants not long after induction of diabetes with alloxan; and (4) IT-92 rats that received an intraportal injection of at least 1500 and usually 2000 syngeneic pancreatic islets soon after induction of diabetes with alloxan. "