Diabetes Insipidus

A disease that is characterized by frequent urination, excretion of large amounts of dilute URINE, and excessive THIRST. Etiologies of diabetes insipidus include deficiency of antidiuretic hormone (also known as ADH or VASOPRESSIN) secreted by the NEUROHYPOPHYSIS, impaired KIDNEY response to ADH, and impaired hypothalamic regulation of thirst.

Networked: 1941 relevant articles (57 outcomes, 87 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hypopituitarism (Sheehan's Syndrome)
2.	Diabetes Mellitus
3.	Hypothyroidism
4.	Dehydration (Water Stress)
5.	Neoplasm Metastasis (Metastasis)

Experts

1.	Rej, Soham: 6 articles (04/2015 - 01/2011)
2.	Thompson, C J: 6 articles (03/2015 - 10/2002)
3.	Oiso, Yutaka: 6 articles (01/2014 - 11/2003)
4.	Segal, Marilyn: 5 articles (04/2015 - 03/2013)
5.	Low, Nancy C P: 5 articles (04/2015 - 01/2011)
6.	Agha, Amar: 5 articles (09/2007 - 12/2004)
7.	Holcroft, Christina: 4 articles (04/2015 - 06/2014)
8.	Mucsi, Istvan: 4 articles (04/2015 - 06/2014)
9.	Sherlock, M: 4 articles (03/2015 - 01/2006)
10.	Grossman, Ashley B: 4 articles (10/2014 - 06/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Diabetes Insipidus:

1.	Deamino Arginine Vasopressin (Desmopressin)FDA LinkGeneric 01/01/1990 - "During nursing the diabetes insipidus improved significantly whereby DDAVP doses could be reduced to 20-10 percent. " 05/01/2009 - "Overall, growing experience with DDAVP has shown that it is a safe and effective treatment for diabetes insipidus caused by a variety of factors." 11/01/2004 - "Diabetes insipidus (DI) was observed in 10/18 patients before surgery and in 15/18 patients after surgery; during surgery it was effectively treated with synthetic desmopressin (DDAVP) and hydroelectrolytic solutions. " 09/01/2000 - "The patient achieved a remission but continued to need desmopressin therapy to control his diabetes insipidus. " 02/01/1978 - "Two patients with acute postoperative diabetes insipidus were effectively treated with 5 microgram of dDAVP every 14 to 18 h. "
2.	Vasopressins (Vasopressin)IBA 05/01/2001 - "Using plasma vasopressin measurement with a highly sensitive RIA as gold standard test, nine patients were classified as having primary polydipsia, whereas 18 had partial or complete cranial diabetes insipidus. " 01/01/1982 - "The use of animals with diabetes insipidus, particularly the Brattleboro homozygous (DI) rat, may help to circumvent a number of methodological problems and provide a useful model for assessing the role of vasopressin in the control of renal hemodynamics. " 08/01/2000 - "The naturally-occurring frame-shift mutation in the hereditary diabetes insipidus (Brattleboro) rat completely eliminated vasopressin expression. " 02/01/1983 - "She was treated with intranasal vasopressin for diabetes insipidus and responded well to treatment. " 03/01/2000 - "Spontaneous genetic models of vasopressin deficiency, such as the Brattleboro rat and human familial diabetes insipidus, have facilitated many studies of vasopressin. "
3.	Arginine Vasopressin (Argipressin)IBA 12/01/1995 - "Transient diabetes insipidus in pregnancy--a consequence of enhanced placental clearance of arginine vasopressin." 05/01/2003 - "In this study, we have assessed the utility of a third-generation equine infectious anemia virus (EIAV) in the Brattleboro rat model of diabetes insipidus, in which a mutation in the arginine vasopressin (AVP) gene results in the production of nonfunctional mutant AVP precursor protein. " 09/01/2000 - "Although arginine vasopressin is primarily administered for its antidiuretic effects in the treatment of diabetes insipidus, the study demonstrates the often overlooked vasoactive effect of arginine vasopressin and its use in a patient without diabetes insipidus." 06/01/2015 - "The water deprivation test and a potential role for the arginine vasopressin precursor copeptin to differentiate diabetes insipidus from primary polydipsia." 01/01/2014 - "Arginine vasopressin neuronal loss results from autophagy-associated cell death in a mouse model for familial neurohypophysial diabetes insipidus."
4.	HormonesIBA 01/01/2014 - "Four of these were cured, 10 patients developed postoperative anterior pituitary hormone deficiency, and one patient developed diabetes insipidus. " 04/01/1981 - "These studies have evaluated the relationship between renal PG synthesis and hormone levels in rats with hereditary diabetes insipidus, a species devoid of circulating ADH. " 01/01/1969 - "Micropuncture studies on the influence of antidiuretic hormone on tubular fluid reabsorption in rats with hereditary diabetes insipidus." 04/01/2015 - "Diabetes insipidus (DI) results from inadequate output of Antidiuretic Hormone (ADH) from the pituitary gland (central DI) or the inability of the kidney tubules to respond to ADH (nephrogenic DI). " 02/01/2015 - "They presented with symptoms of expanding sellar mass (83.3%), symptoms of anterior pituitary hormone deficiencies (58.3%), and diabetes insipidus (16.7%). "
5.	Hydrocortisone (Cortisol)FDA LinkGeneric 07/01/1998 - "Partial tumour remission was achieved resulting in decreased cortisol production and disappearance of the diabetes insipidus. " 10/01/2003 - "We report the results of a prospective randomized controlled trial, which looked at the incidence of postoperative diabetes insipidus (DI) following the use of three different hydrocortisone protocols, and the results of a study, on the incidence of DI and cortisol response in patients not given hydrocortisone. " 10/01/2003 - "Hydrocortisone dose and postoperative diabetes insipidus in patients undergoing transsphenoidal pituitary surgery: a prospective randomized controlled study." 01/01/2009 - "Following introduction of hydrocortisone, he developed transient diabetes insipidus which spontaneously resolved after 4 months. " 01/01/2004 - "Diabetes insipidus (DI) developed after the administration of hydrocortisone. "
6.	Prednisolone (Predate)FDA LinkGeneric 01/01/2007 - "Prednisolone therapy improved all of her clinical findings except diabetes insipidus. " 04/01/2006 - "Prednisolone therapy improved all of his clinical findings except diabetes insipidus. " 05/01/2009 - "Diabetes insipidus during pregnancy has a variety of causes, some that predate the pregnancy and others that begin during gestation. " 06/21/1957 - "[Diabetogenic action of prednisolone and its effect of diuresis in diabetes insipidus]." 07/07/1956 - "[Prednisolone in the treatment of diabetes insipidus; preliminary note]."
7.	Insulin (Novolin)FDA Link 01/01/1996 - "As part of a prospective, randomized study, the psychological effects of two different treatment regimens on the diagnosis of children and adolescents aged 3-15 years with insulin-dependent diabetes insipidus were evaluated. " 07/01/2007 - "A stimulated copeptin level 45 min after insulin injection of less than 4.75 pm had an optimal diagnostic accuracy to detect diabetes insipidus. " 07/01/2007 - "Copeptin levels in patients with diabetes insipidus were 2.4 +/- 0.5 pm before insulin injection, with a maximum increase to 3.7 +/- 0.7 pm. " 04/10/1975 - "[Diabetes insipidus and immunity - insulin autoimmune syndrome]." 07/01/2007 - "The aim was to study the value of copeptin levels in the diagnosis of diabetes insipidus during insulin-induced hypoglycemia. "
8.	ChlorpropamideFDA LinkGeneric 01/01/1991 - "The present in vitro microperfusion study examined whether chlorpropamide (CPM) has a direct effect on hydraulic conductivity (Lp x 10(-6) cm/atm.sec) and 14C-urea permeability (Pu x 10(-5) cm/sec) in the middle and distal inner medullary collecting duct (IMCD) obtained from acutely water-loaded Wistar rats and rats homozygous for diabetes insipidus (DI). " 01/01/1970 - "Studies on the mechanism of "chlorpropamide antidiuresis" in diabetes insipidus." 10/01/1983 - "Chlorpropamide action on renal concentrating mechanism in rats with hypothalamic diabetes insipidus." 02/15/1983 - "Chlorpropamide in pregnancy and transient neonatal diabetes insipidus." 03/01/1982 - "The use of chlorpropamide in diabetes insipidus in children."
9.	Adrenocorticotropic Hormone (ACTH)FDA Link 07/01/2011 - "Post-operatively, visual fields improved in 83% of patients with impairment, whereas there was no reversal of ACTH or TSH deficiency or of diabetes insipidus. " 10/01/2012 - "Diabetes insipidus and multiple anterior pituitary defects (GH, ACTH and TSH) were found preoperatively, and substitutive therapy was started. " 10/01/2011 - "A homozygous p.R189H mutation was identified in a female patient of consanguineous parentage with semilobar HPE, diabetes insipidus, and TSH and ACTH insufficiency. " 09/01/2009 - "In all these series main pituitary deficits were GH (25%), ACTH (15%), gonadotrope (8.5%), TSH (6%) and diabetes insipidus (4%). " 09/01/2009 - "In all these series the main pituitary deficits were: GH (14%), ACTH (14%), gonadotrope (18%), TSH (7%) and diabetes insipidus (4%). "
10.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 12/01/2000 - "We examined the data supporting the efficacy of cyclophosphamide in diabetes insipidus. " 11/01/2005 - "Diabetes insipidus symptoms mostly regressed; renal and pulmonary findings completely disappeared with glucocorticoid and pulse cyclophosphamide treatment. " 06/01/2000 - "We describe an 8 year-old girl with established diabetes insipidus who developed cyclophosphamide-associated antidiuresis. " 11/25/1995 - "[Vasculitis and diabetes insipidus, reversible by administration of cyclophosphamide]." 10/05/1978 - "Diabetes insipidus associated with Wegener's granulomatosis successfully treated with cyclophosphamide."

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 01/01/1996 - "CHOP chemotherapy proved to be an effective treatment for both the systemic and CNS involvement in our patient, but diabetes insipidus has persisted. " 11/01/2004 - "All three patients initially developed multifocal LCH lesions during early childhood (age <3 years) that responded well to chemotherapy; however, two of the three patients later developed diabetes insipidus. " 07/01/2013 - "Response to surgery and chemotherapy and development of diabetes insipidus were the main outcome measures. " 01/01/2013 - "Diabetes insipidus: a challenging diagnosis with new drug therapies." 07/15/2012 - "Reversal of LCH-related diabetes insipidus and reappearance of posterior pituitary bright spot with low-dose chemotherapy."
2.	Radiotherapy 09/01/1995 - "Furthermore, low dose radiotherapy is a successful treatment for LCH-dependent masses in the hypothalamus; however, normalization or regression of CT abnormalities after radiotherapy did not affect the clinical diabetes insipidus status." 10/01/2012 - "Gross-total was associated with increased rates of diabetes insipidus (OR 7.7, p = 0.05) compared with the combination of STR and radiotherapy (RT). " 08/01/2003 - "CNS involvement was a significant risk factor for lower scores, but sex, diabetes insipidus, and cranial radiotherapy were not. " 01/01/1996 - "Diabetes insipidus, however, remained, in spite of X ray radiotherapy for the pituitary lesion." 09/01/1995 - "The hypothalamic mass disappeared six months after low dose radiotherapy with persistence of diabetes insipidus and loss of thirst sensation. "
3.	Hypophysectomy 07/01/1988 - "For the surviving dogs in both studies, diabetes insipidus developed immediately after hypophysectomy and resolved within 2 weeks. " 02/01/1957 - "Further studies of diabetes insipidus following hypophysectomy in man." 09/01/2008 - "Diabetes insipidus is a clinical entity that is often seen in neurosurgical patients either during or immediately after transsphenoidal hypophysectomy. " 01/01/2006 - "A decrease in the function and the number of AVP-producing and -secreting magnocellular neurons after hypophysectomy, suggests that the clinical improvement of postoperative diabetes insipidus-like symptoms may not be related to the recovery of AVP secretion." 01/01/2006 - "Acute diabetes insipidus-like symptoms have been reported as a complication after hypophysectomy in dogs. "
4.	Ventriculoperitoneal Shunt 11/01/1999 - "Transient diabetes insipidus following Escherichia coli meningitis complicated by ventriculoperitoneal shunt." 11/01/2014 - "Although the association between intraventricular hemorrhage and diabetes insipidus has been described in preterm infants, the association between diabetes insipidus and hydrocephalus, and the fact that such central diabetes insipidus could be reversible with the reduction of ventricular size, either because of spontaneous resolution or the placement of ventriculo-peritoneal shunt is first described here in neonates."
5.	Peripheral Blood Stem Cell Transplantation (Peripheral Stem Cell Transplantation) 11/01/1998 - "After a 26-month follow-up following intensive chemotherapy including autologous peripheral stem cell transplantation and local radiotherapy, lymphoma symptoms had disappeared, but the patient's condition had only partially improved with regard to diabetes insipidus. "