Dextrocardia

A congenital defect in which the heart is located on the right side of the THORAX instead of on the left side (levocardia, the normal position). When dextrocardia is accompanied with inverted HEART ATRIA, a right-sided STOMACH, and a left-sided LIVER, the combination is called dextrocardia with SITUS INVERSUS. Dextrocardia may adversely affect other thoracic organs.

Also Known As:

Networked: 289 relevant articles (7 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Situs Inversus
2.	Atrial Fibrillation
3.	Tachycardia (Tachyarrhythmias)
4.	Syncope (Fainting)
5.	Fistula

Experts

1.	Yamada, Takumi: 4 articles (01/2018 - 09/2008)
2.	Fan, Chengming: 2 articles (11/2022 - 01/2021)
3.	Liu, Liming: 2 articles (11/2022 - 01/2021)
4.	Luo, Cheng: 2 articles (11/2022 - 01/2021)
5.	Song, Long: 2 articles (11/2022 - 01/2021)
6.	Zhang, Hao: 2 articles (11/2022 - 01/2021)
7.	Liu, Xu: 2 articles (05/2021 - 09/2010)
8.	Saito, Shigeru: 2 articles (03/2021 - 06/2015)
9.	Dong, Jian-Zeng: 2 articles (01/2021 - 05/2012)
10.	Ma, Chang-Sheng: 2 articles (01/2021 - 05/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Dextrocardia:

1.	Cytidine Monophosphate (CMP)IBA 11/01/2022 - "The results of the present study demonstrate that the CMP-IV is safe and effective in eliminating AF in dextrocardia patients concomitant with valvular surgery." 11/01/2022 - "From February 2016 to September 2020, three dextrocardia patients with persistent AF and valvular diseases were referred to this institution for valvular and CMP-IV surgery. " 11/01/2022 - "This paper summarizes the CMP-IV procedure performed concomitantly with valvular surgery in patients with situs inversus dextrocardia at this institution. " 11/01/2022 - "However, the efficacy and safety of CMP-IV in situs inversus dextrocardia are largely unknown. " 01/01/2021 - "The case herein is one of the first to report on adopting the CMP-IV procedure for situs inversus dextrocardia patients with complex valvuloplasty operation. "
2.	Cytoplasmic DyneinsIBA 12/01/2022 - "This study identified a foetus with SRTD3 with situs inversus totalis with mirror-image dextrocardia in a Chinese family, revealing two novel compound heterozygous dynein cytoplasmic 2 heavy chain 1 (DYNC2H1) variants, expanding the phenotypic spectrum of SRTD3. "
3.	AtropineFDA LinkGeneric 04/01/1960 - "[Study of the atrial electrocardiogram and of its changes after atropine in cases of dextrocardia with nodal rhythm]."
4.	cytidylyl-(3'-5')-cytidine (CpC)IBA 03/01/2023 - "We report the first CPC incidence of 0.0057%, provide the by far most inclusive CPC epidemiology based on 429 patients and could not find reliable proof that there has ever been a patient with left-sided CPC which was associated with dextrocardia." 03/01/2023 - "Two publications reported one case of left-sided CPC with dextrocardia, either not showing left/right marking or only showing the CPC with the aortic knob on the same side. " 03/01/2023 - "The aim of this study was to identify the hitherto unknown incidence of congenital pseudarthrosis of the clavicle (CPC), based on a cohort of continuous livebirths born in our hospital, to review the literature and investigate if there is evidence supporting the published association between left-sided CPC and dextrocardia. "
5.	Anesthetics (Anesthetic Agents)IBA 01/01/2021 - "Conclusion: The anesthetic management of patients presenting with dextrocardia is complex. " 01/01/2021 - "In this report, we discuss the perioperative anesthetic management of a patient presenting with dextrocardia. " 03/29/2021 - "Anesthetic management of coronary artery bypass grafting surgery (CABG) in a dextrocardia patient with situs inversus totalis is rarely encountered and seldom reported in the literature. " 07/01/2017 - "Off-pump Coronary Artery Bypass Surgery in a Patient with Dextrocardia and Situs Inversus: Anesthetic, Surgical Consideration and Role of Transesophageal Echocardiography." 01/01/2016 - "Fontan's circulation with dextrocardia, recent pulmonary embolism, and inferior vena cava filter: Anesthetic challenges for urgent hysterectomy."
6.	Fumigant 93 (D-D)IBA 01/01/2005 - "A very rare case of a newborn with dextrocardia, complete transposition of the great arteries {S,D,D}, ventricular septal defect, aortic arch hypoplasia, juxtaposition of the morphologically right atrial appendage and superoinferior ventricles is herein presented. " 04/01/1998 - "Dextrocardia and corrected transposition of the great arteries (I,D,D) in a case of Kartagener's syndrome: a unique association." 10/01/1983 - "[Open heart surgery for corrected transposition of the great arteries, situs inversus (I,D,D) in dextrocardia]." 01/01/2019 - "Congenitally corrected transposition of great arteries (TGA) with situs inversus and D-looping of the ventricles and aorta (congenitally corrected TGA {I,D,D}) was found in four patients, while the other six patients exhibited mirror-image dextrocardia {I,L,L}. " 04/01/1998 - "This paper reports on a case of Kartagener's syndrome associated with dextrocardia, corrected transposition of the great arteries (I,D,D), ventricular septal defect, and valvar pulmonary stenosis in an 8-year-old girl."
7.	Proteins (Proteins, Gene)FDA Link 02/01/2016 - "Here, we identify new patients with dextrocardia who have mutations in CFAP53, a coiled-coil domain containing protein. " 01/01/2015 - "Dextrocardia and symmetric hypertrophic cardiomyopathy with multiple mutations of genes encoding the sarcomere proteins." 10/30/2021 - "Of the thirteen novel variants, two, c.11839 + 1G > A in dynein, axonemal, heavy chain 11 (DNAH11) and p.Lys92Trpfs in dynein, axonemal, intermediate chain 1 (DNAI1) were associated with dextrocardia with situs inversus, and one, p.Gly21Val in coiled-coil domain-containing protein 40 (CCDC40), with absent inner dynein arms. "
8.	Dyneins (Dynein)IBA 09/01/1992 - "A case was defined as genetic if one or more of the following were present: dextrocardia, ciliary beat frequency less than 10 Hz, or an average dynein arm count (outer, inner, or both) of less than two per ciliary cross-section. " 07/01/1983 - "Two patients, who did not have dextrocardia and who had had respiratory difficulties from birth onwards, had the immotile cilia syndrome, with total absence of dynein arms in the ciliary cross-sections. " 10/30/2021 - "Of the thirteen novel variants, two, c.11839 + 1G > A in dynein, axonemal, heavy chain 11 (DNAH11) and p.Lys92Trpfs in dynein, axonemal, intermediate chain 1 (DNAI1) were associated with dextrocardia with situs inversus, and one, p.Gly21Val in coiled-coil domain-containing protein 40 (CCDC40), with absent inner dynein arms. "
9.	Coenzyme A (CoA)IBA 01/01/2018 - "Transposition of the great arteries occurs rarely in patients with mirror image dextrocardia and situs inversus, while the combination with severe coarctation of the descending aorta (CoA) makes the anatomy even more unusual. " 01/01/2007 - "Newborn echocardiographic screening enables pediatricians to detect abnormal cardiac findings early and accurately, especially heart diseases without murmur such as COA, ASD, CAVC, dextrocardia, small muscular VSD, small PDA, hypertrophic cardiomyopathy and cardiac tumor. " 12/01/1997 - "Preoperative cardiac catheterization and angiography confirmed the diagnosis of TGA with IVS, CoA, atrial septal defect, patent ductus arteriosus, persistent left superior vena cava, left sided juxta-positioning of appendages and dextrocardia. " 01/01/2007 - "As well as physically patent ductus arteriosus (PDA) (2420 cases), and patent foramen ovale (PFO) (5813 cases), we also found atrial septal defect (ASD) (161 cases), muscular-type ventricular septal defect (VSD) (123 cases), perimembranous type VSD (58 cases), coarctation of the aorta (COA) (1 case), pulmonic stenosis (PS) (1 case), peripheral pulmonic stenosis (PPS) (15 cases), common atrioventricular canal (CAVC) (1 case), transposition of the great arteries (TGA) (3 cases), double outlets of the right ventricle (DORV) (2 cases), tetralogy of Fallot (TF) (2 cases), hypertrophic cardiomyopathy (2 cases), dextrocardia (2 cases) and cardiac tumor (2 cases). "
10.	SteroidsIBA 11/27/1983 - "[Steroid therapy of the mother, dextrocardia and developmental anomalies in the offspring]." 01/01/2020 - "We report a case of an elderly Caucasian male with past medical history of dextrocardia with situs inversus totalis, polymyalgia rheumatica, history of cryptogenic stroke, and severe mitral regurgitation with mitral valve prolapse, who presented with acute heart failure symptoms, including severe dyspnea on exertion and worsening lower extremity edema in the setting of immunosuppression with steroids for a year-old diagnosis of polymyalgia rheumatica. "

Therapies and Procedures

1.	Catheter Ablation 09/01/1997 - "Using biplane fluoroscopy, accessory pathway catheter ablation in dextrocardia is as safe, easy, and useful as that for normal heart structure cases, and does not require a lengthy procedure." 09/01/1997 - "Radiofrequency catheter ablation of an accessory pathway in dextrocardia." 09/01/1994 - "This report presents another case in which radiofrequency catheter ablation was used in a patient with dextrocardia. " 09/01/1994 - "There has been limited experience with radiofrequency catheter ablation in patients with dextrocardia. " 12/01/2020 - "Trans-coronary sinus puncture for catheter ablation and left atrial appendage closure device implantation in a patient with dextrocardia and persistent right superior vena cava."
2.	Catheters 01/01/2022 - "For patients with dextrocardia, the key to successful ablation was adjusting for projection angulation and different catheter manipulation compared with a standard case because of the mirror image of a normal heart." 05/01/2019 - "Furthermore, we propose a stepwise approach to arterial access, fluoroscopy, and catheter selection for operator reference while treating dextrocardia patients." 01/01/2017 - "This case suggested that the interventional management of such patients follows the same general rules as for non-dextrocardia patients, but the manipulation of the catheter and projection position choices need to be taken into consideration to obtain optimal benefits for the patient." 12/01/2011 - "The feasibility of using Ikari left catheter via the right radial approach in a patient with dextrocardia for better guiding support." 08/01/2004 - "In a young adult patient having situs solitus with dextrocardia the attempted pulmonary artery catheter placement for emergency mitral valve replacement required an unduly long length (50cm) of catheter insertion to get into right ventricle and then into pulmonary artery. "
3.	Therapeutics 10/01/2019 - "Multicenter Experience of Subcutaneous Implantable Cardioverter-Defibrillator Therapy in Patients With Dextrocardia." 03/01/2016 - "Valve sparing techniques can be used effectively even in patients with complicated clinical scenarios (like dextrocardia and annuloaortic ectasia) to avoid the potential risks related to prosthetic valve implantation and lifelong anticoagulation therapy. " 05/24/2016 - "[Interventional therapy of ventricular septal defect in a patient with mirror-image dextrocardia]." 01/01/2016 - "Dextrocardia is a congenital anomaly, which may have coexistent coronary artery disease (CAD), arrhythmias and conventional indications for device therapy. " 01/01/2010 - "Resynchronization therapy transvenous approach in dextrocardia and congenitally corrected transposition of great arteries."
4.	Maze Procedure 11/01/2022 - "Cox-Maze IV Procedure Concomitant with Valvular Surgery In Situs Inversus Dextrocardia: A Single-center Experience in China." 01/01/2021 - "Case Report: The Cox-Maze IV Procedure in the Mirror: The Use of Three-Dimensional Printing for Pre-operative Planning in a Patient With Situs Inversus Dextrocardia." 08/01/2014 - "[Maze procedure in a case of dextrocardia with atrial septal defect and persistent left superior vena cava]." 01/01/2021 - "The safety and efficacy of the Cox-Maze IV procedure (CMP-IV) for situs inversus dextrocardia patients with atrial fibrillation is yet to be determined. "
5.	Operative Time 10/01/2004 - "Prior information of a left bronchoesophageal fistula in two of the neonates with dextrocardia greatly helped us in saving operative time and difficulties and postoperative hassles. "