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Dextroamphetamine (Dexedrine)

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The d-form of AMPHETAMINE. It is a central nervous system stimulant and a sympathomimetic. It has also been used in the treatment of narcolepsy and of attention deficit disorders and hyperactivity in children. Dextroamphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulating release of monamines, and inhibiting monoamine oxidase. It is also a drug of abuse and a psychotomimetic.

Also Known As:

Dexedrine; Dexamphetamine; DextroStat; Curban; Dexamfetamine; d Amphetamine; Celltech Brand of Dextroamphetamine Sulfate; Dextro-Amphetamine Sulfate; Dextroamphetamine Sulfate; GlaxoSmithKline Brand of Dextroamphetamine Sulfate; Mallinckrodt Brand of Dextroamphetamine Sulfate; Oxydess; Pasadena Brand of Dextroamphetamine; Shire Brand of Dextroamphetamine Sulfate; Vortech Brand of Dextroamphetamine Sulfate; d-Amphetamine Sulfate; dextro-Amphetamine; Dextro Amphetamine Sulfate; Sulfate, Dextroamphetamine; d Amphetamine Sulfate; dextro Amphetamine; d-Amphetamine; Benzeneethanamine, alpha-methyl-, (S)-

Networked: 758 relevant articles (67 outcomes, 112 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Amines: 1422
  - Ethylamines: 5
    - Phenethylamines: 14
      - Amphetamines: 396
        Amphetamine: 2316
        Dextroamphetamine: 758
        lisdexamfetamine dimesylate: 96
        d-N-butylamphetamine
        d-N-ethylamphetamine
        d-N-propylamphetamine
        dexamyl
        dextroamphetamine N-dithiocarbamate
        dextroamphetamine N-thiourea

Experts

1.	Check, J H: 28 articles (01/2015 - 01/2005)
2.	Quevedo, João: 19 articles (08/2015 - 05/2006)
3.	Valvassori, Samira S: 14 articles (08/2015 - 05/2006)
4.	Cohen, R: 13 articles (01/2015 - 01/2009)
5.	Kapczinski, Flávio: 10 articles (06/2012 - 05/2006)
6.	Dal-Pizzol, Felipe: 9 articles (03/2013 - 05/2006)
7.	Varela, Roger B: 7 articles (08/2015 - 12/2011)
8.	Killgore, William D S: 7 articles (02/2012 - 09/2005)
9.	Katsoff, B: 6 articles (01/2014 - 01/2005)
10.	Balkin, Thomas J: 6 articles (02/2012 - 09/2005)

Related Diseases

1.	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 01/01/2014 - "The demonstration that aminopeptidase-like activity in red blood cell cytosol is responsible for the hydrolysis of LDX extends our understanding of the smooth and consistent systemic delivery of d-amphetamine by LDX and the long daily duration of efficacy of the drug in relieving the symptoms of attention-deficit/hyperactivity disorder. " 08/01/1999 - "The aim of this paper is to determine the efficacy of dexamphetamine in adult attention deficit hyperactivity disorder (ADHD) in a naturalistic setting. " 06/01/2011 - "However, there do not appear to be any published clinical studies that have characterized the behavioral and cardiovascular effects of intranasally administered d-amphetamine, which is commonly prescribed for Attention Deficit Hyperactivity Disorder. " 08/01/1999 - "A randomised, double-blind, placebo-controlled trial of dexamphetamine in adults with attention deficit hyperactivity disorder." 04/01/2015 - "Dexamphetamine (dAMPH) is a stimulant drug that is widely used recreationally as well as for the treatment of attention-deficit hyperactivity disorder (ADHD). "
2.	Cocaine-Related Disorders (Cocaine Addiction) 05/01/2002 - "Sustained release dextroamphetamine (15-30 mg but not 30-60 mg) improved retention in patients with cocaine dependence." 04/01/2010 - "The results of preclinical laboratory experiments and clinical trials indicate that agonist replacements such as d-amphetamine may be a viable option for managing cocaine dependence. " 10/01/2009 - "Recent studies have investigated D-amphetamine as a potential agonist medication for cocaine dependence. " 01/01/2009 - "The results of preclinical laboratory studies and clinical trials indicate that agonist replacements like D-amphetamine may be a viable option for managing cocaine dependence. " 08/01/2003 - "Pilot randomized double blind placebo-controlled study of dexamphetamine for cocaine dependence."
3.	Seizures (Seizure) 01/01/1977 - "Subsequent administration of d-amphetamine eliminated seizures, except at 4c, at which temperature only stereotyped behavior was observed. " 01/01/1983 - "Studies on the pharmacology of d-amphetamine on maximal electroconvulsive seizure in young chicks." 12/08/2000 - "Neuronal degeneration was detected in the tenia tecta and other regions of the anterior limbic system of male weanling rats 3 days after four doses of 5 mg/kg d-amphetamine (4 x 5 mg/kg AMPH) when seizures occurred during AMPH exposure. " 01/01/2000 - "Seizure was elicited after lethal doses of d-amphetamine (75 mg/kg, i.p.) administration in mice. " 10/26/1998 - "Neuronal degeneration in rat forebrain resulting from D-amphetamine-induced convulsions is dependent on seizure severity and age."
4.	Weight Loss (Weight Reduction) 01/01/2015 - "Our treatment with dexamphetamine, diet, and exercise was well tolerated and effective for initial weight loss. " 05/04/2006 - "Although these subjects ingested approximately 50% of the amount of food ingested by free-feeding SHU9119-infused rats, they displayed no weight loss and no change in sensitivity to D-amphetamine. " 10/01/1980 - "The dextroamphetamine group was superior in terms of behavioral treatment participation, extent of eating and exercise habit change, and weight loss. " 02/01/1949 - "Dexedrine and weight reduction." 01/01/2015 - "The mean weight gain in the 6 months after ceasing dexamphetamine was 4.5 kg (95% CI 1.9-7.2, p = 0.003), leaving a mean weight loss at 12 months from baseline of 7.0 kg (95% CI -13.4 to -0.6, p = 0.03). "
5.	Pain (Aches) 01/01/2014 - "Marked improvement of pain from long-term fibromyalgia with dextroamphetamine sulfate in a woman who failed to improve with conventional pharmacologic treatment." 01/01/2015 - "Dextroamphetamine sulfate relieved pain from adenomyosis similar to its effect on endometriosis." 01/01/2014 - "Dextroamphetamine sulfate 20 mg daily was prescribed to a 45-year-old woman who complained of 20 plus years of severe stabbing retrorbital pain who was diagnosed with keratoconus but failed to gain relief from bilateral corneal implants. " 05/01/1986 - "Combinations of morphine and d-amphetamine have been shown to be more effective in relieving pathological and experimental pain with fewer side effects than morphine alone. " 01/01/2014 - "Dextroamphetamine sulfate, a very effective drug for pelvic pain relieved severe retroorbital stabbing pain in a woman with keratoconus who failed to respond to bilateral corneal implants."

Related Drugs and Biologics

1.	Methylphenidate (Ritalin)
2.	modafinil (armodafinil)
3.	Pemoline (Cylert)
4.	Trimeprazine (Alimemazine)
5.	Dextroamphetamine (Dexedrine)
6.	Dopamine (Intropin)
7.	Caffeine (No Doz)
8.	Morphine (MS Contin)
9.	Chlordiazepoxide (Elenium)
10.	Bupropion (Wellbutrin)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Induced Hypothermia
3.	Oral Administration
4.	Speech Therapy (Therapy, Speech)
5.	Activities of Daily Living (ADL)