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Desoxycorticosterone (DOCA)

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21-Hydroxypregn-4-ene-3,20-dione. Desoxycorticosterone acetate (DOCA) is used as replacement therapy in ADDISON DISEASE.

Also Known As:

DOCA; Deoxycorticosterone; Desoxycortone; 11-Decorticosterone; 21-Hydroxy-4-pregnene-3,20-dione; Decortin; 11 Decorticosterone; 21 Hydroxy 4 pregnene 3,20 dione; 21 Hydroxyprogesterone; Acetate, Desoxycorticosterone; 21-Hydroxyprogesterone; Cortexone; Desoxycorticosterone Acetate; Pregn-4-ene-3,20-dione, 21-hydroxy-

Networked: 2202 relevant articles (68 outcomes, 241 trials/studies)

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Drug Context: Research Results

Experts

1.	Fink, Gregory D: 26 articles (01/2015 - 02/2002)
2.	Watts, Stephanie W: 23 articles (03/2015 - 02/2002)
3.	Galligan, James J: 18 articles (10/2013 - 02/2002)
4.	Brown, Lindsay: 14 articles (01/2016 - 02/2002)
5.	Schiffrin, Ernesto L: 12 articles (07/2013 - 02/2002)
6.	Chen, Alex F: 10 articles (05/2012 - 02/2002)
7.	Luft, Friedrich C: 9 articles (03/2013 - 08/2002)
8.	Kim, Soo Wan: 9 articles (01/2013 - 04/2002)
9.	Ndisang, Joseph Fomusi: 8 articles (01/2015 - 06/2008)
10.	Harrison, David G: 8 articles (06/2012 - 04/2003)

Related Diseases

1.	Hypertension (High Blood Pressure) 03/01/2015 - "DOCA-salt treatment did not increase the protein levels of ER stress and autophagy markers in NT mice, despite a significant increase in BP. In addition, these markers were not affected by hACE2 overexpression in the brain, despite a significant reduction of hypertension in SL mice. " 12/08/2011 - "Treatment with compound 3 or 4 resulted in a significant reduction or attenuation of blood pressure in an established or developing model of hypertension, deoxycorticosterone acetate-treated rats. " 01/02/2008 - "Following the development of hypertension, GluR1 spine and puncta counts were significantly greater in DOCA-salt rats than controls. " 01/01/1986 - "Vasoconstrictor responses to the electrical nerve stimulation were significantly greater in DOCA-salt hypertension in the chronic phase than the age-matched normotensive controls. " 06/01/1990 - "The results of this study indicate that only the combination of 1% NaCl in tap water and DOCA administration is effective in accelerating hypertension in adult SHR. "
2.	Fibrosis (Cirrhosis) 07/01/2015 - "In contrast, DOCA-salt hypertensive rats treated with different dose of GSPE or ALM showed a significant improvement of renal injury with decreased urine protein, KW/BW, degree of renal fibrosis, renal total MDA and Hyp contents compared to the untreated group. " 01/01/2014 - "Thus, During myocardial fibrosis of DOCA induced salt-sensitive hypertensive rats, PDGFRα acts at early stage, but PDGFRβ functions in the whole process. " 01/01/2014 - "The severity of myocardial fibrosis and PVCA/VA ratio in DOCA+IMA group were markedly lower than those in DOCA group although they were higher than those in CON group. " 01/01/2014 - "At days 28, the severity of myocardial fibrosis and PVCA/VA ratio in DOCA group were significantly increased when compared with CON group. " 01/01/2014 - "Role of PDGFs/PDGFRs signaling pathway in myocardial fibrosis of DOCA/salt hypertensive rats."
3.	Cardiomegaly (Heart Hypertrophy) 08/01/2009 - "After 6 weeks DOCA, Gas 6(-/-) mice developed similar telemetric blood pressure elevations compared to wild-type mice but were protected from cardiac hypertrophy. " 09/01/2002 - "The DOCA and DOCA+L-NAME groups showed relative renal and cardiac hypertrophy, which was not observed in the DOCA+L-NAME+prazosin group. " 08/01/2002 - "In addition, DOCA-salt treatment alters the amounts of Kv transcripts independently to cardiac hypertrophy, suggesting that the mineralocorticoid may be involved in Kv gene expression." 01/01/1998 - "ET-1 may not play a critical role in the pathophysiology of the severe concentric cardiac hypertrophy present in DOCA-salt hypertensive rats." 11/01/1997 - "These findings report for the first time the cardiac cell-specific implication of Ang II and the intracellular calcium signaling pathway stimulated by the AT1 receptor in cardiac hypertrophy in DOCA-salt-hypertensive rats."
4.	Hypertrophy 04/01/1996 - "A marked decrease in vascular wall hypertrophy was observed in the FR139317-treated DOCA-salt rats. " 01/01/2016 - "Mal C exerts anti-hypertensive property in DOCA-salt rats by reducing oxidative stress and organ hypertrophy, and improving endothelial and vascular functions. " 11/01/2015 - "Urinary excretion of deoxycorticosterone was higher in 11βHSD1 knockout mice, and there was hypertrophy of cells in the zona fasciculata of the adrenal cortex. " 08/01/2015 - "In conclusion, Ang-(1-7) protective signaling against DOCA-induced diastolic dysfunction occurs independently of BP attenuation and is mediated by the activation of pathways involved in Ca(2+) handling, hypertrophy, and survival. " 09/01/2011 - "EO significantly decreased arterial blood pressure and heart rate along with cardiac and renal hypertrophy in a dose-dependent fashion as compared to DOCA control rats. "
5.	Ganglion Cysts (Ganglion) 12/01/2001 - "We found deoxycorticosterone-salt and stroke prone-spontaneously hypertensive rats to exhibit a decreased erectile response, recorded as intracavernosal pressure/mean arterial pressure (ICP/MAP) upon electrical stimulation of the major pelvic ganglion. " 06/01/2003 - "Likewise, both maximal percentage and absolute decreases in MAP elicited by i.v. injection of the ganglion blocker, hexamethonium (30 mg/kg), were significantly greater in DOCA-salt hypertensive than in control rats. " 12/01/2002 - "Likewise, both maximal percent and absolute decreases in MAP elicited by i.v. injection of the ganglion blocker, hexamethonium (30 mg/kg body wt.), were significantly greater in DOCA-salt-hypertensive than in control rats. " 03/01/2000 - "Likewise, both maximal percent and absolute decreases in MAP elicited by i.v. hexamethonium (30 mg/kg), a ganglion blocker, were significantly greater in DOCA-salt hypertensive than in control rats. " 01/01/1987 - "Also, DOCA-salt rats had increased depressor response to hexamethonium bromide, a ganglion blocker. "

Related Drugs and Biologics

1.	Desoxycorticosterone (DOCA)
2.	Messenger RNA (mRNA)
3.	Hexamethonium (Hexamethonium Bromide)
4.	Collagen Type I (Type I Collagen)
5.	Ascorbic Acid (Vitamin C)
6.	Hormones
7.	candesartan cilexetil (Amias)
8.	Tryptophan (L-Tryptophan)
9.	cilnidipine
10.	Sodium

Related Therapies and Procedures

1.	Adrenalectomy
2.	Oral Administration
3.	Surgical Instruments (Clip)
4.	Nephrectomy
5.	Denervation