Desoxycorticosterone (Deoxycorticosterone)

A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE

Also Known As:

Deoxycorticosterone; Desoxycortone; 11-Decorticosterone; 21-Hydroxy-4-pregnene-3,20-dione; 11 Decorticosterone; 21 Hydroxy 4 pregnene 3,20 dione; 21 Hydroxyprogesterone; 21-Hydroxyprogesterone; Cortexone; Pregn-4-ene-3,20-dione, 21-hydroxy-

Networked: 1466 relevant articles (24 outcomes, 171 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fink, Gregory D: 18 articles (01/2019 - 02/2002)
2.	Watts, Stephanie W: 12 articles (01/2016 - 02/2002)
3.	Schiffrin, Ernesto L: 9 articles (07/2013 - 02/2002)
4.	Grobe, Justin L: 8 articles (01/2022 - 03/2013)
5.	Osborn, John W: 8 articles (01/2019 - 05/2008)
6.	Ndisang, Joseph Fomusi: 8 articles (01/2015 - 06/2008)
7.	Matsumura, Y: 8 articles (03/2003 - 03/2000)
8.	Demirel-Yilmaz, Emine: 7 articles (05/2022 - 01/2015)
9.	Sigmund, Curt D: 7 articles (01/2022 - 03/2013)
10.	Duarte, Juan: 7 articles (08/2021 - 03/2004)

Related Diseases

1.	Hypertension (High Blood Pressure) 05/01/1967 - "A study of the effects of renal artery constriction on hypertension caused by deoxycorticosterone." 05/01/2022 - "Hypertension was induced in male Wistar rats by deoxycorticosterone-acetate + salt administration for 12 weeks. " 05/03/2019 - "Hypertension due to a deoxycorticosterone-secreting adrenal tumour diagnosed during pregnancy." 02/15/2016 - "Hypertension was induced in mice by surgical removal of a kidney and by subcutaneous administration of a pellet with deoxycorticosterone. " 06/01/1997 - "The discriminating feature of this form of sex-reversal is the presence of hypertension due to the elevated serum deoxycorticosterone levels. "
2.	Cardiomegaly (Heart Hypertrophy) 01/01/1977 - "Chronic (15-week) dietary administration of 2-thio-6-aminouracil (TAU, 1.0 and 2.0 g/kg food) provided significant protection against elevation of blood pressure and cardiac hypertrophy in male rats treated with desoxycorticosterone trimethylacetate (DTMA) (5.0 mg twice weekly for 10 weeks). " 07/01/1992 - "It is concluded that Gi alpha contributes to the reduced adenylate cyclase activity in cardiac hypertrophy in one-kidney, one clip and reduced renal mass and to a smaller extent in deoxycorticosterone. " 10/01/1997 - "The quinapril treatment had no long-term blood pressure-lowering effect nor did it reduce the associated cardiac hypertrophy in deoxycorticosterone-NaCl hypertension. " 07/01/1994 - "Cardiac hypertrophy induced by hypertension was produced in rats by giving saline drinking fluid and subcutaneous deoxycorticosterone acetate for four weeks. " 01/01/2019 - "To establish a cardiac hypertrophy model, deoxycorticosterone acetate (DOCA, 40 mg/kg/wk) was subcutaneously injected for 4 weeks into Sprague-Dawley rats. "
3.	Fibrosis (Cirrhosis) 09/13/2023 - "Our data from the deoxycorticosterone model of cardiac fibrosis shows that this imaging method and downstream analyses, including background correction, are robust and easy to perform. " 01/01/2017 - "The characteristic cardiac inflammatory/fibrotic response to a deoxycorticosterone (DOC)/salt for 8 weeks was significantly blunted in CLOCKΔ19 mice when compared with wild-type mice, despite a modest increase at "baseline" for fibrosis and macrophage number in CLOCKΔ19 mice. " 05/01/2012 - "Anti-fibrotic effect of Aliskiren in rats with deoxycorticosterone induced myocardial fibrosis and its potential mechanism." 01/01/2017 - "Deoxycorticosterone/Salt-Mediated Cardiac Inflammation and Fibrosis Are Dependent on Functional CLOCK Signaling in Male Mice." 01/01/2014 - "This study aimed to investigate the role of PDGF/PDGFR signaling pathway in myocardial fibrosis of desoxycorticosterone (DOCA) induced salt-sensitive hypertensive rats and explore the influence of PDGF/PDGFR signaling pathway on fibroblasts and myofibroblasts in the heart. "
4.	Hypertrophy 11/01/2015 - "Urinary excretion of deoxycorticosterone was higher in 11βHSD1 knockout mice, and there was hypertrophy of cells in the zona fasciculata of the adrenal cortex. " 05/01/1971 - "An effect of deoxycorticosterone upon the ileum simulating compensatory hypertrophy of the gut." 08/01/1958 - "Relative resistance to the hypertensive effects of desoxycorticosterone during active phase of renal compensatory hypertrophy." 01/01/1952 - "[Congenital hypertrophy of the adrenals in a male newborn associated with clinical insufficiency of desoxycorticosterone]." 03/01/1952 - "Growth effects of desoxycorticosterone and cortisone with special reference to compensatory renal hypertrophy."
5.	Inflammation (Inflammations) 07/01/1957 - "Effect of desoxycorticosterone on inflammation after local administration." 01/01/1957 - "[Action of desoxycorticosterone on tissue & the physiopathology of rheumatic inflammation]." 01/01/1958 - "[Experimental studies on the effect of inflammation, cortisone and desoxycorticosterone on functional cytomorphol of the lymphatic structures]." 01/01/2017 - "Deoxycorticosterone/Salt-Mediated Cardiac Inflammation and Fibrosis Are Dependent on Functional CLOCK Signaling in Male Mice." 01/01/2019 - "Therefore, this study was conducted to elucidate the contribution of renal nerves to renal inflammation in the deoxycorticosterone (DOCA)-salt rat, a model in which RDN decreases AP and abolishes renal inflammation. "

Related Drugs and Biologics

1.	Acetates (Acetic Acid Esters)
2.	Salts
3.	Desoxycorticosterone Acetate (DOCA)
4.	Angiotensin II
5.	Steroids
6.	Vasopressins (Vasopressin)
7.	Hormones (Hormone)
8.	Testosterone (Sustanon)
9.	Amiloride (Midamor)
10.	Protein Kinase C

Related Therapies and Procedures

1.	Therapeutics
2.	Nephrectomy
3.	Intraperitoneal Injections
4.	Adrenalectomy
5.	Surgical Instruments (Clip)