Desmosterol

01/01/1986 - "On an individual basis, a concentration of CSF desmosterol equal to or higher than the mean plus twice the standard deviation for the reference group of patients with no CNS tumor, is considered a positive result. "
01/01/1986 - "The desmosterol test for the diagnosis of central nervous system (CNS) tumors is proposed in a simplified form. "
12/01/1977 - "The evidence indicated that desmosterol levels in the CSF may reflect the growth potential of these neoplasms."
01/01/1986 - "Applied to 55 patients with tumoral and non tumoral CNS disease, the new test detects average levels of CSF desmosterol in tumor bearing patients that are tenfold higher than in the absence of CNS neoplasia. "
07/01/1964 - "[EFFECT OF TRIPARANOL ON DESMOSTEROL CONTENT OF SOME EXPERIMENTAL CEREBRAL TUMORS]."

03/01/1965 - "THE RELATIONSHIP OF DESMOSTEROL TO EXPERIMENTAL ATHEROSCLEROSIS."
02/01/1963 - "Desmosterol deposition in human and experimental atherosclerosis."
03/17/1962 - "Deposition of desmosterol in the lesions of experimental atherosclerosis."
11/23/2021 - "Here, we report that desmosterol, the most abundant cholesterol biosynthetic intermediate in human coronary artery lesions, plays an essential role during atherogenesis, serving as a key molecule integrating cholesterol homeostasis and immune responses in macrophages. "
11/10/2017 - "Recent biochemical investigations fuel the hope that inhibition of DHCR24, resulting in an accumulation of desmosterol, can open new therapeutic options for treating hepatitis C virus infections, certain forms of cancer and atherosclerosis. "

01/01/2019 - "Desmosterolosis and desmosterol homeostasis in the developing mouse brain."
07/13/2009 - "Mutations of DHCR24 gene result in inhibition of the enzymatic activity of seladin-1, causing an accumulation of desmosterol and leading to a lethal disorder called desmosterolosis. "
09/01/2011 - "Desmosterolosis is a rare autosomal recessive disorder of elevated levels of the cholesterol precursor desmosterol in plasma, tissue and cultured cells. "
04/01/2008 - "Desmosterolosis is an autosomal recessive disease due to mutation in the DHCR24 gene, with low cholesterol and high desmosterol levels. "
12/15/2002 - "We describe here the first living patient with desmosterolosis and show biochemical evidence in plasma and cultured lymphoblasts for an autosomal recessive deficiency of 24-dehydrocholesterol reductase (DHCR24). "

06/01/1975 - "Desmosterol is found in various organs of rats that show signs of myotonia in their skeletal muscle as a result of treatment with 20.25-diazacholesterol. "
06/01/1975 - "Desmosterol accumulation in rats with experimental myotonia."
07/15/1966 - "Desmosterol accumulation in combination with a specific drug effect may cause the observed myotonia."
02/01/1982 - "Sarcolemmal desmosterol accumulation and membrane physical properties in 20,25-diazacholesterol myotonia."
08/01/1975 - "Myotonia induced by single doses of 20, 25 diazacholesterol: increased muscle and plasma desmosterol levels, unaltered (Na+ + K+)-ATPase activity of erythrocyte ghosts."

01/01/2017 - "We have studied non-cholesterol sterol markers of cholesterol synthesis (lanosterol and desmosterol) and oxysterols (7α-hydroxy-4-cholesten-3-one, 24S-hydroxycholesterol and 27-hydroxycholesterol) in 200 affected subjects with primary hypercholesterolemia of genetic origin, negative for mutations in LDLR, APOB, PCSK9 and APOE genes (non-FH GH) and 100 normolipemic controls. "
09/14/2006 - "Phytosterols (beta-sitosterol, cholestanol and campesterol) and cholesterol precursors (desmosterol and lathosterol), have been suggested as important biochemical markers of intestinal cholesterol absorption and liver biosynthesis, respectively, and as useful clinical parameters in the study of hypercholesterolemia, beta-sitosterolemia, atherosclerosis and cardiovascular disease, including pharmacological response to hypolipidemic agents. "