Desmosine

A rare amino acid found in elastin, formed by condensation of four molecules of lysine into a pyridinium ring.

Also Known As:

4-(4-Amino-4-Carboxybutyl)-1-(5-Amino-5-Carboxypentyl)-3,5-bis(3-Amino-3-Carboxypropyl)pyridinium; Pyridinium, 4-(4-amino-4-carboxybutyl)-1-(5-amino-5-carboxypentyl)-3,5-bis(3-amino-3-carboxypropyl)-

Networked: 123 relevant articles (7 outcomes, 20 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ma, Shuren: 10 articles (01/2021 - 05/2007)
2.	Starcher, Barry: 9 articles (01/2013 - 04/2003)
3.	Turino, Gerard M: 6 articles (01/2021 - 05/2007)
4.	Cantor, Jerome: 5 articles (06/2022 - 06/2015)
5.	Lin, Yong Y: 5 articles (07/2017 - 05/2007)
6.	Luisetti, M: 5 articles (04/2012 - 06/2000)
7.	Liu, Xingjian: 4 articles (01/2021 - 06/2015)
8.	Turino, Gerard: 4 articles (12/2018 - 06/2015)
9.	Luisetti, Maurizio: 4 articles (04/2013 - 09/2011)
10.	Memtsoudis, Stavros G: 4 articles (12/2012 - 09/2009)

Related Diseases

1.	Chronic Obstructive Pulmonary Disease (COPD) 10/01/2011 - "As longitudinal desmosine changes likely reflect the elevated elastic fiber turnover associated with the progression of lung damage and destruction in COPD, they appear to be a suitable marker for application in long-term studies. " 05/01/2023 - "High urinary desmosine is independently associated with an increased risk of long-term mortality in COPD patients. " 05/01/2023 - "High urinary desmosine is associated with long-term mortality in patients with COPD." 03/03/2015 - "The plasma levels of desmosine are lower in high risk COPD patients than those in normal subjects or low risk COPD patients. " 03/03/2015 - "The plasma concentration of desmosine was significantly lower in COPD high risk group than healthy non-smokers (mean difference -70, 95%CI: -128--11, P = 0.021), healthy smokers (mean difference -60, 95%CI: -118--3, P = 0.039) and COPD low risk group (mean difference -67, 95%CI: -122--12, P = 0.018). "
2.	Lung Injury 12/05/2012 - "The significantly lower values of desmosine in the study group suggest that this treatment may be protective against lung injury." 09/01/2010 - "In the context of previous studies, our findings suggest that desmosine may be a marker of lung injury in this setting. " 09/01/2009 - "In the context of previous studies, our findings suggest that desmosine may be a marker of postoperative lung injury. " 01/01/1986 - "The urinary content of desmosine in experimental and clinical studies as a test for some lung injuries." 09/01/2010 - "We recently evaluated this marker in patients undergoing knee surgery, but the utility of desmosine as a marker of lung injury in patients undergoing spine surgery remains unstudied. "
3.	Cardiovascular Diseases (Cardiovascular Disease) 01/01/2022 - "Recent studies show promising results for plasma desmosine (pDES), an elastin-specific degradation product, as a marker of cardiovascular disease (CVD) outcomes. " 07/29/2011 - "Releases of the elastin cross-links desmosine (DES) and isodesmosine (IDE) may reflect elastin degradation in cardiovascular diseases. "
4.	Emphysema 06/01/2002 - "Urinary desmosine may be used to identify subjects at risk of developing emphysema and to assess the efficacy of therapeutic interventions." 01/01/2018 - "The changes in emphysema index did not differ between the two urinary desmosine groups over 3 years of follow-up. " 06/01/2002 - "In patients with no evidence or only mild emphysema, desmosine excretion values were significantly higher (P=0.006) than those of patients with moderate to severe emphysema. " 01/01/1991 - "The blotchy mouse, lung desmosine, and emphysema." 01/01/2018 - "Urinary desmosine is associated with emphysema severity and frequent exacerbation in patients with COPD."
5.	Lung Diseases (Lung Disease) 04/01/1985 - "At the end of the first week of life, desmosine excretion was significantly greater (p less than 0.05) in the infants who later developed BPD than in the "low-O2" infants without severe lung disease. " 01/01/2008 - "Desmosine levels in BALF may be useful to investigate lung disease." 02/01/1991 - "Urinary desmosine, elastolysis, and lung disease." 12/01/2009 - "Sputum desmosine, a novel measure of acute structural lung injury, may serve as a marker of structural lung damage occurring during exacerbations of lung disease in CF." 06/01/2000 - "MEKC of desmosine and isodesmosine in urine of chronic destructive lung disease patients."

Related Drugs and Biologics

1.	Elastin
2.	diethylstilbestrol monophosphate (PDES)
3.	midesteine
4.	Indicators and Reagents (Reagents)
5.	Isodesmosine
6.	Amino Acids
7.	Pancreatic Elastase (Elastase)
8.	pyridinoline
9.	Biomarkers (Surrogate Marker)
10.	Collagen

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Knee Replacement Arthroplasty (Total Knee Replacement)
4.	Mechanical Ventilators (Ventilator)
5.	Lasers (Laser)