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Desmosine

A rare amino acid found in elastin, formed by condensation of four molecules of lysine into a pyridinium ring.

Also Known As:

4-(4-Amino-4-Carboxybutyl)-1-(5-Amino-5-Carboxypentyl)-3,5-bis(3-Amino-3-Carboxypropyl)pyridinium; Pyridinium, 4-(4-amino-4-carboxybutyl)-1-(5-amino-5-carboxypentyl)-3,5-bis(3-amino-3-carboxypropyl)-

Networked: 91 relevant articles (7 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Starcher, Barry: 9 articles (01/2013 - 04/2003)
2.	Luisetti, M: 5 articles (04/2012 - 06/2000)
3.	Ma, Shuren: 4 articles (06/2015 - 05/2007)
4.	Luisetti, Maurizio: 4 articles (04/2013 - 09/2011)
5.	Memtsoudis, Stavros G: 4 articles (12/2012 - 09/2009)
6.	Lin, Yong Y: 4 articles (03/2012 - 05/2007)
7.	Iadarola, Paolo: 3 articles (04/2013 - 10/2011)
8.	Sculco, Thomas P: 3 articles (12/2012 - 09/2009)
9.	Iadarola, P: 3 articles (04/2012 - 06/2000)
10.	Turino, Gerard M: 3 articles (10/2011 - 05/2007)

Related Diseases

1.	Chronic Obstructive Pulmonary Disease (COPD) 10/01/2011 - "As longitudinal desmosine changes likely reflect the elevated elastic fiber turnover associated with the progression of lung damage and destruction in COPD, they appear to be a suitable marker for application in long-term studies. " 03/03/2015 - "The plasma levels of desmosine are lower in high risk COPD patients than those in normal subjects or low risk COPD patients. " 03/03/2015 - "The plasma concentration of desmosine was significantly lower in COPD high risk group than healthy non-smokers (mean difference -70, 95%CI: -128--11, P = 0.021), healthy smokers (mean difference -60, 95%CI: -118--3, P = 0.039) and COPD low risk group (mean difference -67, 95%CI: -122--12, P = 0.018). " 03/03/2015 - "The plasma desmosine concentrations in healthy non-smokers, healthy smokers, low risk and high risk COPD patients were (200 ± 159), (191 ± 105), (197 ± 118) and (131 ± 47) ng/L respectively. " 03/03/2015 - "To explore the relationship between desmosine plasma levels and exacerbation risk in patients with chronic obstructive pulmonary disease (COPD). "
2.	Lung Injury 12/05/2012 - "The significantly lower values of desmosine in the study group suggest that this treatment may be protective against lung injury." 09/01/2010 - "In the context of previous studies, our findings suggest that desmosine may be a marker of lung injury in this setting. " 09/01/2010 - "The objective of this prospective observational study was to determine if urine desmosine levels, a marker of lung injury, increase in response to the periopreative insults of anterior and posterior spine surgery. " 09/01/2009 - "In the context of previous studies, our findings suggest that desmosine may be a marker of postoperative lung injury. " 01/01/1986 - "The urinary content of desmosine in experimental and clinical studies as a test for some lung injuries."
3.	Emphysema 06/01/2002 - "Urinary desmosine may be used to identify subjects at risk of developing emphysema and to assess the efficacy of therapeutic interventions." 06/01/2002 - "In patients with no evidence or only mild emphysema, desmosine excretion values were significantly higher (P=0.006) than those of patients with moderate to severe emphysema. " 01/01/1991 - "The blotchy mouse, lung desmosine, and emphysema." 03/03/2015 - "The plasma concentration of desmosine was negatively correlated with exacerbation frequency (r = -0.409, P = 0.002), mMRC scores (r = -0.447, P = 0.010) and emphysema severity (r = -0.386, P = 0.047) in COPD patients. " 06/01/2002 - "Urinary desmosine excretion is inversely correlated with the extent of emphysema in patients with chronic obstructive pulmonary disease."
4.	Lung Diseases (Lung Disease) 04/01/1985 - "At the end of the first week of life, desmosine excretion was significantly greater (p less than 0.05) in the infants who later developed BPD than in the "low-O2" infants without severe lung disease. " 01/01/2008 - "Desmosine levels in BALF may be useful to investigate lung disease." 01/01/1995 - "Measurement of urinary desmosine as an indicator of acute pulmonary disease." 12/01/2009 - "Sputum desmosine, a novel measure of acute structural lung injury, may serve as a marker of structural lung damage occurring during exacerbations of lung disease in CF." 06/01/2000 - "MEKC of desmosine and isodesmosine in urine of chronic destructive lung disease patients."
5.	Pulmonary Fibrosis (Hamman Rich Syndrome) 01/01/2008 - "Urinary excretion of desmosine has been reported to be increased in patients with pulmonary fibrosis; however, several investigators have pointed out that measuring urinary desmosine is not a very useful indicator of lung wall destruction. " 09/01/1989 - "Elevations of lavage desmosine after bleomycin were temporarily associated with remodeling of the lung as indicated by increased total lung collagen, reduced diffusing capacity and lung compliance, and histologic evidence of pulmonary fibrosis. " 03/01/1984 - "Cross-linked elastin synthesis was measured in the intratracheal bleomycin model of interstitial pulmonary fibrosis by incorporation of 14C-lysine into the elastin-specific crosslinks, desmosine and isodesmosine. " 03/01/1984 - "Measurement of cross-linked elastin synthesis in bleomycin-induced pulmonary fibrosis using a highly sensitive assay for desmosine and isodesmosine."

Related Drugs and Biologics

1.	Matrix Metalloproteinases
2.	MR 889
3.	Isodesmosine
4.	Elastin
5.	pyridinoline
6.	Pancreatic Elastase (Elastase)
7.	Collagen
8.	Biological Markers (Surrogate Marker)
9.	Amino Acids
10.	Hydroxyproline (4 Hydroxyproline)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Mechanical Ventilators (Ventilator)
3.	Lasers (Laser)
4.	Arthroplasty