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Deslanoside (Cedilanid-D)

Subscribe to New Research on Deslanoside

Deacetyllanatoside C. A cardiotonic glycoside from the leaves of Digitalis lanata.

Also Known As:

Cedilanid-D; Desacetyl Lanatoside; Deslanatoside C; C, Desacetyldigilanide; C, Desacetyllanatoside; C, Deslanatoside; Cedilanid D; CedilanidD; Lanatoside, Desacetyl; Desacetyldigilanide C; Desacetyllanatoside C; Card-20(22)-enolide, 3-((O-beta-D-glucopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-12,14-dihydroxy-, (3beta,5beta,12beta)-

Networked: 34 relevant articles (0 outcomes, 0 trials/studies)

Drug Context: Research Results

Experts

1.	Tang, Meng-Jie: 1 article (10/2012)
2.	Li, Peng: 1 article (10/2012)
3.	Hu, Hao: 1 article (10/2012)
4.	Zang, Wei-Jin: 1 article (10/2012)
5.	Yu, Xiao-Jiang: 1 article (10/2012)
6.	Du, Ke-Xin: 1 article (10/2012)
7.	He, Hui-Kang: 1 article (10/2012)
8.	Ma, Li-Xia: 1 article (10/2012)
9.	Gao, Yang: 1 article (10/2012)
10.	Wang, Xing-Hui: 1 article (10/2012)

Related Diseases

1.	Cardiac Arrhythmias (Arrythmia) 11/01/1982 - "These results are consistent with the hypothesis that the increased resistance to arrhythmia induced by desacetyl lanatoside C in decorticated rats is mediated by the posterior hypothalamus." 11/01/1982 - "To examine the role of the posterior hypothalamus in the increased resistance of decorticated rats to arrhythmia induced by toxic doses of desacetyl lanatoside C, four groups of animals were injected with this drug: group 1 rats had a craniotomy; group 2 rats had a craniotomy and functional decortication; group 3 rats had a craniotomy and a hypothalamic lesion; and group 4 rats had a craniotomy, hypothalamic lesion and functional decortication. " 12/01/1971 - "Effects of beta-adrenoreceptor blocking agents on the deslanoside-induced arrhythmia and cardiac arrest in guinea pigs." 10/31/2012 - "Ethanol (0.4, 0.8 and 1.6 g/kg) consumption remarkably increased the cumulative dosage of deslanoside to induce ventricualr premature contraction (P < 0.01) on deslanoside-induced arrhythmia in guinea pigs. " 09/01/1975 - "In addition, pretreatment with 5 mmole/kg taurine i.v. had no significant effect on the doses of deslanoside to produce ventricular arrhythmia and fibrillation."
2.	Ventricular Fibrillation 11/01/1983 - "However, this dose of deslanoside caused ventricular fibrillation in all 6 experiments. " 11/01/1982 - "Functional ablation of the cerebral cortex by cortical spreading depression (CSD) significantly increased the dose of desacetyl lanatoside C required to induce A-V block and ventricular fibrillation. " 11/01/1979 - "Experiments were performed in cats and arterial blood samples were taken prior to initiating deslanoside infusion and at the point when it appeared from the ECG that ventricular fibrillation was imminent. " 10/01/1991 - "Calcitonin gene-related peptide was able to eliminate sinus standstill and ventricular fibrillation resulting from administration of desacetyldigilanide-C. " 07/01/1983 - "With 200 micrograms/Kg of digoxin or deslanoside, ventricular fibrillation was induced in all 5 donor dogs within 75 min after digitalis administration. "
3.	Heart Failure 07/01/1989 - "In the heart failure patients, Cedilanid-D significantly increased systolic and pulse pressures, whereas mean arterial pressure was unchanged. " 07/01/1989 - "To determine whether or not these contrasting vascular responses are due to differing autonomic actions of the drug, we compared the responses to intravenous administration of Cedilanid-D (0.02 mg/kg) in eight normal subjects (mean age, 23 +/- 1 years) and eight patients with moderate-to-severe heart failure (mean age, 52 +/- 5 years, NYHA Class III-IV). " 10/01/1979 - "The effect of pentaformilgitoxin and deslanoside on heart rate, blood pressure and cardiac output was compared in six patients with heart failure. " 10/01/1979 - "Comparison of hemodynamic effects induced by pentaformilgitoxin and deslanoside in patients with heart failure." 10/01/1970 - "[Desacetyl-lanatoside C: therapeutic effect in congestive heart failure]."
4.	Heart Diseases (Heart Disease) 10/01/1965 - "[Desacetyl-lanatoside-C in heart diseases]." 09/15/1965 - "[Experiences with desacetyl-lanatoside C in treatment and in preparation for surgery of surgical heart disease patients]." 09/15/1965 - "[On the use of desacetyl-lanatoside C in therapy of uncompensated heart diseases. " 09/01/1963 - "[THE TREATMENT OF DECOMPENSATED HEART DISEASES WITH A NEW DIGITALIC DRUG (DESACETYLLANATOSIDE C)]."
5.	Vomiting 12/01/1987 - "These cats then vomited appropriately in response to the injection of deslanoside which induces emesis through an action on the area postrema. " 08/01/1981 - "Deslanoside (160 micrograms/kg) produced emesis in 15 cats beginning in 4.4 +/- 1.9 min (mean +/- S.D.). " 03/01/1965 - "EMESIS INDUCED BY INTRACEREBROVENTRICULAR INJECTIONS OF APOMORPHINE AND DESLANOSIDE IN NORMAL AND CHEMORECEPTIVE TRIGGER ZONE ABLATED DOGS."

Related Drugs and Biologics

1.	Picrotoxin
2.	Pentylenetetrazole (Metrazol)
3.	Deslanoside (Cedilanid-D)
4.	Tetraethylammonium (Tetraethylammonium Bromide)
5.	Hexamethonium (Hexamethonium Bromide)
6.	Calcitonin Gene-Related Peptide
7.	Taurine
8.	Serotonin (5 Hydroxytryptamine)
9.	Procaine (Novocaine)
10.	Oxytocin (Pitocin)

Related Therapies and Procedures

1.	Artificial Respiration (Mechanical Ventilation)
2.	Injections
3.	Craniotomy
4.	Cesarean Section (Caesarean Section)