Dermatitis Herpetiformis (Disease, Duhring's)

Rare, chronic, papulo-vesicular disease characterized by an intensely pruritic eruption consisting of various combinations of symmetrical, erythematous, papular, vesicular, or bullous lesions. The disease is strongly associated with the presence of HLA-B8 and HLA-DR3 antigens. A variety of different autoantibodies has been detected in small numbers in patients with dermatitis herpetiformis.

Also Known As:

Disease, Duhring's; Duhring Disease; Disease, Duhring; Duhrings Disease; Duhring's Disease

Networked: 1028 relevant articles (35 outcomes, 68 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Celiac Disease (Celiac Sprue)
2.	Bullous Pemphigoid (Pemphigoid)
3.	Pemphigus (Pemphigus Vulgaris)
4.	Dermatitis Herpetiformis (Disease, Duhring's)
5.	Exanthema (Rash)

Experts

1.	Kaukinen, Katri: 17 articles (05/2022 - 07/2004)
2.	Hervonen, Kaisa: 15 articles (05/2022 - 07/2014)
3.	Reunala, Timo: 15 articles (05/2022 - 01/2003)
4.	Zillikens, Detlef: 13 articles (07/2020 - 04/2007)
5.	Kárpáti, Sarolta: 12 articles (11/2021 - 03/2002)
6.	Caproni, Marzia: 11 articles (02/2021 - 05/2002)
7.	Reunala, T: 11 articles (01/2021 - 12/2000)
8.	Salmi, Teea: 10 articles (05/2022 - 03/2018)
9.	Antiga, Emiliano: 10 articles (02/2021 - 08/2011)
10.	Zone, John J: 9 articles (01/2018 - 01/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Dermatitis Herpetiformis:

1.	Glutens (Glutelin)IBA 11/01/2003 - "To investigate the effects on long-term remission of dermatitis herpetiformis in patients who underwent a gluten challenge and subsequently reintroduced dietary gluten. " 02/10/1973 - "Clearance of skin lesions in dermatitis herpetiformis after gluten withdrawal." 12/01/1986 - "Gluten challenge in children with dermatitis herpetiformis: a clinical, morphological and immunohistological study." 10/01/2022 - "Coeliac disease and dermatitis herpetiformis are immune-mediated diseases triggered by the consumption of gluten in genetically predisposed individuals. " 05/16/2022 - "Sex-differences in Gluten-free Dietary Adherence and Clinical Symptoms in Patients with Long-term Treated Dermatitis Herpetiformis."
2.	Dapsone FDA Link 09/01/1992 - "During the period of the study, dapsone-mediated control of the dermatitis herpetiformis in all six patients was unchanged. " 01/01/2019 - "We report this case to raise awareness of facial involvement in dermatitis herpetiformis as well as the possibility of topical dapsone as a therapeutic option." 02/18/2013 - "A 50-year-old male with well-controlled type 1 DM, Mb Addison and coeliac disease was diagnosed with dermatitis herpetiformis and treated with dapsone. " 12/31/2012 - "Letter to the editor: Application of dapsone 5% gel in a patient with dermatitis herpetiformis." 10/01/2003 - "Dapsone was reintroduced for exacerbation of dermatitis herpetiformis 4 months later. "
3.	Immunoglobulin G (IgG)IBA 03/01/1989 - "Skin biopsy specimens from 2 patients with dermatitis herpetiformis were examined by means of direct immunofluorescence with fluoresceinated aggregated human IgG (FAIgG) for the presence of tissue antiglobulin activity. " 01/01/1989 - "IgG-AGA were found in five other patients, in one of whom dermatitis herpetiformis (DH) was diagnosed. " 09/01/1982 - "Parameters of IgG1 binding to monocytes of patients with dermatitis herpetiformis and normal individuals of HLA-B8/Drw3 haplotype were not significantly different from controls, despite the previous demonstration of retarded IgG-mediated clearance in one-half of such subjects. " 08/01/1980 - "Higher levels of IgG containing complexes were also noted in dermatitis herpetiformis patients at a low level of statistical significance (p < .1). " 01/01/1979 - "Peripheral blood lymphocytes from patients with dermatitis herpetiformis and healthy controls were investigated in order to determine the percentages of B-lymphocytes, T-lymphocytes and cells with receptors for the Fc part of human IgG (EA-RFC). "
4.	Immunoglobulin A (IgA)IBA 05/01/1995 - "Immunofluorescence detection of stippled IgA in dermal papillae has been considered the gold standard in the diagnosis of dermatitis herpetiformis (DH). " 02/02/2021 - "This study shows that granular deposits of IgA represent a low sensitive, but highly specific, cutaneous marker of coeliac disease independent of dermatitis herpetiformis." 12/01/2015 - "The purpose of this study was to examine the utility of direct immunofluorescence (DIF) testing for the characteristic immunoglobulin A deposits of dermatitis herpetiformis (DH) in patients stratified into high and low clinical suspicion subgroups. " 12/01/1992 - "Criteria for inclusion in the study were a clinical diagnosis of dermatitis herpetiformis plus granular deposition of IgA in dermal papillae by direct immunofluorescence of uninvolved skin, or histopathologic findings consistent with the disease. " 12/01/1989 - "Although direct immunofluorescence testing of skin biopsy specimens remains the most definitive diagnostic test for dermatitis herpetiformis, indirect immunofluorescence assay of serum for IgA-EMA is a minimally invasive study with a high sensitivity and specificity for dermatitis herpetiformis."
5.	AntibodiesIBA 09/21/2020 - "TG6 Auto-Antibodies in Dermatitis Herpetiformis." 05/01/2014 - "[Dermatitis herpetiformis antibodies: What the dermatologist must know]." 07/01/2013 - "eTG antibodies were tested in 308 adult patients' sera: 44 patients with untreated dermatitis herpetiformis (UDH), 99 patients with untreated coeliac disease (UCD), 70 dermatological controls and 95 gastrointestinal controls. " 09/01/1998 - "Endomysium and antigliadin antibodies in dermatitis herpetiformis and other bullous diseases." 02/01/1992 - "Ultrastructural binding sites of endomysium antibodies from sera of patients with dermatitis herpetiformis and coeliac disease."
6.	Protein Glutamine gamma Glutamyltransferase 2IBA 01/01/2003 - "Our results suggest that tissue transglutaminase can be recognised in the basal epidermal layer both of patients with dermatitis herpetiformis and controls. " 01/01/2001 - "Tissue transglutaminase antibody assessment in dermatitis herpetiformis." 01/01/2003 - "To study the distribution of tissue transglutaminase in the skin of dermatitis herpetiformis patients and controls, and to investigate whether the dermal IgA deposits, diagnostic for dermatitis herpetiformis, are related to tissue transglutaminase expression in the skin. " 03/01/2007 - "Tissue transglutaminase (tTG) is an autoantigen in coeliac disease and the related disorder, dermatitis herpetiformis. " 11/01/2005 - "Medical pearl: Using tissue transglutaminase antibodies to diagnose dermatitis herpetiformis."
7.	Proteins (Proteins, Gene)FDA Link 05/02/1996 - "In the pathogenesis of dermatitis herpetiformis the participation of some proteins of the extracellular matrix has not been elucidated so far. " 05/01/1983 - "An immune reaction to wheat protein has been previously proposed to explain the pathogenesis of dermatitis herpetiformis. " 01/01/2017 - "The aim of this study was to evaluate the expression of proteins constituting the JAK/STAT signaling pathway in skin lesions and perilesional area in dermatitis herpetiformis (DH) and bullous pemphigoid (BP), as well as in the control group. " 02/26/1964 - "[PAPER ELECTROPHORETIC STUDIES ON SERUM AND BLISTER FLUID PROTEINS IN DERMATITIS HERPETIFORMIS]." 10/01/2006 - "Using immunohistochemistry technique, we examined the protein expression of matrix metalloproteinases-1, -3, and -9 and the tissue inhibitor metalloproteinase-1 in duodenal biopsies from 30 patients with celiac disease and dermatitis herpetiformis. "
8.	Adrenal Cortex Hormones (Corticosteroids)IBA 09/01/1985 - "Dermatitis herpetiformis responsive to systemic corticosteroids." 04/01/1973 - "Treatment of dermatitis herpetiformis with corticosteroids and a gluten-free diet: a study of jejunal morphology and function." 10/01/1972 - "Change in jejunal structure and function in dermatitis herpetiformis: effect of gluten-free diet and corticosteroids." 04/01/1973 - "The jejunal morphological and functional response to either a gluten-free diet or corticosteroid therapy was studied in six patients with dermatitis herpetiformis. " 01/01/1988 - "In our patient the skin disease presented as herpetiform pemphigus (initial features of dermatitis herpetiformis, followed by misleading polymorphous lesions, rare acantholytic cells, good response to corticosteroids), but there was no eosinophilic spongiosis. "
9.	Fc Receptors (Fc Receptor)IBA 01/22/1981 - "Defective Fc-receptor functions associated with the HLA-B8/DRw3 haplotype: studies in patients with dermatitis herpetiformis and normal subjects." 01/01/1979 - "Studies on Fc-receptor-bearing mononuclear leukocytes from peripheral blood of patients with dermatitis herpetiformis." 01/22/1981 - "Since removal of immune complexes from the circulation is thought to depend on the Fc-receptor function of tissue macrophages, we studied this function by measuring the clearance of IgG-sensitized autologous erythrocytes in 16 patients with dermatitis herpetiformis, in normal controls with the HLA-B8/DRw3 haplotype, and in randomly selected controls. " 01/01/1979 - "Isopaque-Ficoll separated mononuclear cell suspensions from peripheral blood of patients with dermatitis herpetiformis (DH) and healthy controls were investigated by means of a rosette assay for Fc-receptor-bearing leukocytes (EA-RFC), peroxidase staining for monocytes (Pox) and a plaque formation assay (PFC) as well as a 51Cr release assay for cell-mediated cytotoxicity. "
10.	AntigensIBA 10/01/2017 - "We hypothesize that absence of human leucocyte antigen related to dermatitis herpetiformis (DH) in our patient might have influenced the location and distribution of the lesions, so that they were not typical of DH. " 05/01/1988 - "Characterization of the mucosal immune response to dietary antigens in patients with dermatitis herpetiformis." 10/01/1983 - "The 90% incidence of HLA antigen (Te24) in dermatitis herpetiformis." 03/01/1981 - "The incidence of HLA-AI, -B8 and -DR3 antigens was found to be significantly higher (P: = 10(-3), less than 10(-6) and less than 10(-6), respectively) among patients with dermatitis herpetiformis than among the normal population. " 07/01/2012 - "Two diseases that are the result of intolerance to a dietary antigen are celiac disease (CD) and dermatitis herpetiformis (DH). "

Therapies and Procedures

1.	Gluten-Free Diet 10/15/2021 - "In addition, the therapeutic role of a gluten-free diet in the improvement in skin alterations is not fully understood in children and in adult population except for dermatitis herpetiformis. " 02/01/1984 - "We conclude that a gluten free diet is of therapeutic benefit in dermatitis herpetiformis and that spontaneous remission is uncommon in those not on a diet. " 10/01/1998 - "Eleven patients with dermatitis herpetiformis in remission on a gluten-free diet were challenged daily with 50 g oats for six months. " 01/01/1986 - "Out of 98 patients with dermatitis herpetiformis (DH) living in Gothenburg, 14 were in spontaneous remission (29% of the patients without gluten free diet). " 02/01/1972 - "Dermatitis herpetiformis; improvement with gluten-free diet."
2.	Therapeutics 01/01/2023 - "Patients with known high susceptibility to CD, such as a family history of CD, or with the ancestry of high celiac penetrance (eg, Northern Europe, North Africa, etc), dermatitis herpetiformis, or chronic bowel symptoms, we feel should have celiac panel testing before initiating ICI therapy." 06/01/2021 - "S2k guidelines (consensus statement) for diagnosis and therapy of dermatitis herpetiformis initiated by the European Academy of Dermatology and Venereology (EADV)." 09/01/2016 - "The development of BP and dermatitis herpetiformis in the context of checkpoint inhibitor therapy is consistent with previous investigations supporting the importance of effector and regulatory T cells in the pathogenesis of these diseases. " 09/01/1976 - "Current clinical therapeutics: dermatitis herpetiformis." 03/01/1959 - "[On the therapy of dermatitis herpetiformis Duhring]."
3.	Immunomodulation 01/01/1987 - "Due to its influence on dermal inflammatory processes and immunomodulation of the tissue response, etretinate is effective in cutaneous lupus erythematosus, certain bullous disorders like pemphigus herpetiformis, the persistent variant of Grover's disease, dermatitis herpetiformis, and bullous pemphigoid. "
4.	Nephrectomy 10/01/1951 - "Dermatitis herpetiformis with remission following nephrectomy."
5.	Homeopathy 06/01/1946 - "A case of Brocq-Duhring's disease cured by homeopathy."