Dermatitis Herpetiformis (Disease, Duhring's)

Rare, chronic, papulo-vesicular disease characterized by an intensely pruritic eruption consisting of various combinations of symmetrical, erythematous, papular, vesicular, or bullous lesions. The disease is strongly associated with the presence of HLA-B8 and HLA-DR3 antigens. A variety of different autoantibodies has been detected in small numbers in patients with dermatitis herpetiformis.

Also Known As:

Networked: 819 relevant articles (25 outcomes, 55 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Celiac Disease (Celiac Sprue)
2.	Bullous Pemphigoid (Pemphigoid)
3.	Pemphigus (Pemphigus Vulgaris)
4.	Skin Diseases
5.	Dermatitis Herpetiformis (Disease, Duhring's)

Experts

1.	Zillikens, Detlef: 9 articles (11/2014 - 04/2007)
2.	Reunala, T: 8 articles (04/2015 - 12/2000)
3.	Kárpáti, Sarolta: 8 articles (11/2014 - 03/2002)
4.	Fasano, Alessio: 6 articles (10/2015 - 01/2005)
5.	Zone, John J: 6 articles (02/2015 - 01/2004)
6.	Zebrowska, Agnieszka: 6 articles (08/2013 - 12/2005)
7.	Murray, Joseph A: 6 articles (01/2013 - 10/2004)
8.	Collin, P: 5 articles (04/2015 - 12/2000)
9.	Fabbri, Paolo: 5 articles (01/2015 - 05/2002)
10.	Caproni, Marzia: 5 articles (01/2015 - 05/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Dermatitis Herpetiformis:

1.	Glutens (Glutelin)IBA 11/01/2003 - "To investigate the effects on long-term remission of dermatitis herpetiformis in patients who underwent a gluten challenge and subsequently reintroduced dietary gluten. " 02/10/1973 - "Clearance of skin lesions in dermatitis herpetiformis after gluten withdrawal." 12/01/1986 - "Gluten challenge in children with dermatitis herpetiformis: a clinical, morphological and immunohistological study." 02/01/2016 - "This approach should lead to better control over the elimination of dietary gluten intake in conditions such as coeliac disease and dermatitis herpetiformis." 04/01/2013 - "coeliac disease (CD) and its cutaneous manifestation, dermatitis herpetiformis are both (DH) gluten-sensitive diseases. "
2.	Immunoglobulin A (IgA)IBA 05/01/1995 - "Immunofluorescence detection of stippled IgA in dermal papillae has been considered the gold standard in the diagnosis of dermatitis herpetiformis (DH). " 12/01/2015 - "The purpose of this study was to examine the utility of direct immunofluorescence (DIF) testing for the characteristic immunoglobulin A deposits of dermatitis herpetiformis (DH) in patients stratified into high and low clinical suspicion subgroups. " 01/01/2003 - "To study the distribution of tissue transglutaminase in the skin of dermatitis herpetiformis patients and controls, and to investigate whether the dermal IgA deposits, diagnostic for dermatitis herpetiformis, are related to tissue transglutaminase expression in the skin. " 12/01/1992 - "Criteria for inclusion in the study were a clinical diagnosis of dermatitis herpetiformis plus granular deposition of IgA in dermal papillae by direct immunofluorescence of uninvolved skin, or histopathologic findings consistent with the disease. " 12/01/1989 - "Although direct immunofluorescence testing of skin biopsy specimens remains the most definitive diagnostic test for dermatitis herpetiformis, indirect immunofluorescence assay of serum for IgA-EMA is a minimally invasive study with a high sensitivity and specificity for dermatitis herpetiformis."
3.	DapsoneFDA Link 09/01/1992 - "During the period of the study, dapsone-mediated control of the dermatitis herpetiformis in all six patients was unchanged. " 02/18/2013 - "A 50-year-old male with well-controlled type 1 DM, Mb Addison and coeliac disease was diagnosed with dermatitis herpetiformis and treated with dapsone. " 12/31/2012 - "Letter to the editor: Application of dapsone 5% gel in a patient with dermatitis herpetiformis." 05/01/2005 - "Dermatitis herpetiformis that is unable to be controlled using dapsone and a gluten-free diet presents a therapeutic challenge. " 10/01/2003 - "Dapsone was reintroduced for exacerbation of dermatitis herpetiformis 4 months later. "
4.	Immunoglobulin G (IgG)IBA 03/01/1989 - "Skin biopsy specimens from 2 patients with dermatitis herpetiformis were examined by means of direct immunofluorescence with fluoresceinated aggregated human IgG (FAIgG) for the presence of tissue antiglobulin activity. " 01/01/1989 - "IgG-AGA were found in five other patients, in one of whom dermatitis herpetiformis (DH) was diagnosed. " 09/01/1982 - "Parameters of IgG1 binding to monocytes of patients with dermatitis herpetiformis and normal individuals of HLA-B8/Drw3 haplotype were not significantly different from controls, despite the previous demonstration of retarded IgG-mediated clearance in one-half of such subjects. " 06/24/1982 - "IgG deposits at the epidermal-dermal junction and high titres of serum IgG (1/10000) reacting with the epidermal-dermal junction of rabbit esophagus were the two criteria that led to the diagnosis of BP. Clinically and histologically this case had at first been diagnosed as dermatitis herpetiformis or benign chronic bullous disease of childhood. " 08/01/1980 - "Higher levels of IgG containing complexes were also noted in dermatitis herpetiformis patients at a low level of statistical significance (p < .1). "
5.	AntibodiesIBA 05/01/2014 - "[Dermatitis herpetiformis antibodies: What the dermatologist must know]." 07/01/2013 - "eTG antibodies were tested in 308 adult patients' sera: 44 patients with untreated dermatitis herpetiformis (UDH), 99 patients with untreated coeliac disease (UCD), 70 dermatological controls and 95 gastrointestinal controls. " 04/01/2011 - "Detection of antibodies to epidermal transglutaminase but not tissue transglutaminase in Japanese patients with dermatitis herpetiformis." 04/01/2010 - "Interestingly, two of the three patients lacked anti-transglutaminase and anti-endomysial antibodies but had a clinical course typical of dermatitis herpetiformis. " 11/01/2005 - "Medical pearl: Using tissue transglutaminase antibodies to diagnose dermatitis herpetiformis."
6.	Adrenal Cortex Hormones (Corticosteroids)IBA 04/01/1973 - "Treatment of dermatitis herpetiformis with corticosteroids and a gluten-free diet: a study of jejunal morphology and function." 09/01/1985 - "Dermatitis herpetiformis responsive to systemic corticosteroids." 10/01/1972 - "Change in jejunal structure and function in dermatitis herpetiformis: effect of gluten-free diet and corticosteroids." 01/01/1988 - "In our patient the skin disease presented as herpetiform pemphigus (initial features of dermatitis herpetiformis, followed by misleading polymorphous lesions, rare acantholytic cells, good response to corticosteroids), but there was no eosinophilic spongiosis. " 11/01/2011 - "On histopathology and immunoflourescence studies it was confirmed to be the rash of dermatitis herpetiformis (DH) and treatment was started with corticosteroids in the last week of December 2008 and dapsone was added from mid January 2009. "
7.	AntigensIBA 03/01/2007 - "Serum samples from 61 biopsy-proven coeliac disease and 10 dermatitis herpetiformis patients were tested for their recognition of both antigens in enzyme-linked immunosorbent assay. " 05/01/1997 - "These results suggest that recognition of an antigen(s) or superantigen is involved in the pathogenesis of dermatitis herpetiformis skin lesions." 05/01/1988 - "Characterization of the mucosal immune response to dietary antigens in patients with dermatitis herpetiformis." 10/01/1983 - "The 90% incidence of HLA antigen (Te24) in dermatitis herpetiformis." 03/01/1981 - "The incidence of HLA-AI, -B8 and -DR3 antigens was found to be significantly higher (P: = 10(-3), less than 10(-6) and less than 10(-6), respectively) among patients with dermatitis herpetiformis than among the normal population. "
8.	Antigen-Antibody Complex (Immune Complex)IBA 01/01/1987 - "Dermatitis herpetiformis: relation between circulating immune complexes, small-intestinal mucosal status, and immunohistopathological findings." 11/24/1984 - "Circulating immune complexes in dermatitis herpetiformis and coeliac disease." 03/01/1984 - "[Circulating immune complexes in dermatitis herpetiformis]." 08/01/1983 - "Renal involvement and circulating immune complexes in dermatitis herpetiformis." 01/22/1981 - "Dermatitis herpetiformis is associated with the HLA-B8/DRw3 haplotype in over 90 per cent of patients, and various percentages have been reported to have circulating immune complexes. "
9.	Fc Receptors (Fc Receptor)IBA 01/22/1981 - "Defective Fc-receptor functions associated with the HLA-B8/DRw3 haplotype: studies in patients with dermatitis herpetiformis and normal subjects." 01/22/1981 - "Since removal of immune complexes from the circulation is thought to depend on the Fc-receptor function of tissue macrophages, we studied this function by measuring the clearance of IgG-sensitized autologous erythrocytes in 16 patients with dermatitis herpetiformis, in normal controls with the HLA-B8/DRw3 haplotype, and in randomly selected controls. "
10.	Actins (F Actin)IBA 10/01/2010 - "IgG-F-actin antibodies in celiac disease and dermatitis herpetiformis." 10/01/2010 - "The purpose of this study was to evaluate of the quality of IgG anti-F-actin antibodies (IgG-AAA) tests compared with IgA tissue transglutaminase antibodies (IgA-TgA) having IgA endomysial antibody (IgA-EmA) as gold standard in celiac disease and dermatitis herpetiformis and to see if there is any relationship between them. "

Therapies and Procedures

1.	Immunomodulation 01/01/1987 - "Due to its influence on dermal inflammatory processes and immunomodulation of the tissue response, etretinate is effective in cutaneous lupus erythematosus, certain bullous disorders like pemphigus herpetiformis, the persistent variant of Grover's disease, dermatitis herpetiformis, and bullous pemphigoid. "
2.	Nephrectomy 10/01/1951 - "Dermatitis herpetiformis with remission following nephrectomy."
3.	Lasers (Laser) 04/01/1993 - "Confocal laser scanning microscopic and immunoelectron microscopic studies of the anatomical distribution of fibrillar IgA deposits in dermatitis herpetiformis."
4.	Gastroenterostomy 03/01/1989 - "In this study the proportions of IgG1-, IgG2-, IgG3-, and IgG4-producing immunocytes were determined by paired immunofluorescence staining in specimens from simple gastritis, gastritis after Billroth II (BII) resection, and gastritis associated with dermatitis herpetiformis (DH). "
5.	Aftercare (After-Treatment) 01/01/2007 - "We describe here the case of a child presenting with a rash and ataxia, diagnosed with dermatitis herpetiformis, in whom neurological symptoms and signs regressed after treatment." 05/01/2004 - "Onset of dermatitis herpetiformis after treatment by interferon and ribavirin for chronic hepatitis C." 11/01/2011 - "Dermatitis herpetiformis, primary hypothyroidism and pituitary mass mimicking macroadenoma regression after treatment with thyroxin, corticosteroids and dapsone."