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Major Depressive Disorder (Major Depressive Disorders)

Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5)
Also Known As:
Major Depressive Disorders; Depressive Disorder, Major; Depressive Disorders, Major; Involutional Depression; Involutional Melancholia; Involutional Paraphrenia; Involutional Paraphrenias; Involutional Psychoses; Involutional Psychosis; Paraphrenias, Involutional; Psychoses, Involutional; Depression, Involutional; Melancholia, Involutional; Paraphrenia, Involutional; Psychosis, Involutional
Networked: 11341 relevant articles (1214 outcomes, 3077 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Bipolar Disorder (Manic Depressive Psychosis)
2. Schizophrenia (Dementia Praecox)
3. Anxiety Disorders (Anxiety Disorder)
4. Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive)
5. Treatment-Resistant Depressive Disorder

Experts

1. Fava, Maurizio: 284 articles (10/2022 - 03/2002)
2. Thase, Michael E: 153 articles (12/2022 - 01/2002)
3. Papakostas, George I: 134 articles (01/2022 - 07/2002)
4. Trivedi, Madhukar H: 133 articles (11/2022 - 01/2002)
5. McIntyre, Roger S: 120 articles (06/2022 - 04/2005)
6. Kennedy, Sidney H: 101 articles (11/2022 - 01/2003)
7. Rush, A John: 91 articles (10/2021 - 10/2000)
8. Mischoulon, David: 87 articles (10/2021 - 03/2002)
9. Zarate, Carlos A: 85 articles (07/2022 - 01/2006)
10. Nierenberg, Andrew A: 79 articles (01/2021 - 03/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Major Depressive Disorder:
1. Antidepressive Agents (Antidepressants)IBA
2. Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA
3. EscitalopramFDA Link
4. Duloxetine Hydrochloride (Cymbalta)FDA Link
5. Venlafaxine Hydrochloride (Effexor)FDA LinkGeneric
6. Fluoxetine (Prozac)FDA LinkGeneric
7. Sertraline (Zoloft)FDA LinkGeneric
8. Serotonin (5 Hydroxytryptamine)IBA
9. VortioxetineIBA
10. Aripiprazole (Abilify)FDA Link

Therapies and Procedures

1. Therapeutics
2. Transcranial Magnetic Stimulation
3. Drug Therapy (Chemotherapy)
4. Transcranial Direct Current Stimulation
5. Deep Brain Stimulation