Deoxyuridine

2'-Deoxyuridine. An antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis. Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemias due to vitamin B12 and folate deficiencies.

Also Known As:

Networked: 238 relevant articles (8 outcomes, 19 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Adelstein, S James: 4 articles (05/2005 - 10/2002)
2.	Kassis, Amin I: 4 articles (05/2005 - 10/2002)
3.	Vogg, Andreas T J: 3 articles (07/2014 - 06/2003)
4.	Wang, Ketai: 3 articles (05/2005 - 11/2004)
5.	Morgenroth, Agnieszka: 2 articles (07/2014 - 11/2008)
6.	Zlatopolskiy, Boris: 2 articles (07/2014 - 11/2008)
7.	Wilson, Keith S: 2 articles (10/2011 - 02/2005)
8.	Brun, Reto: 2 articles (10/2011 - 02/2005)
9.	Johansson, Nils Gunnar: 2 articles (10/2011 - 02/2005)
10.	Whittingham, Jean L: 2 articles (10/2011 - 02/2005)

Related Diseases

1.	Neoplasms (Cancer) 07/01/1993 - "The aim of this study was to measure the tumor uptake and metabolic fate of 5-[125I]iodo-2'-deoxyuridine ([125I]UdR) in humans after a single intratumoral injection. " 04/01/2011 - "FdUrd induced an immediate increase in tumor uptake of 5-[(125)I]iodo-2'-deoxyuridine, that vanished after 6 h, as also confirmed by flow cytometry. " 11/15/2008 - "Preferential tumor targeting and selective tumor cell cytotoxicity of 5-[131/125I]iodo-4'-thio-2'-deoxyuridine." 10/01/2006 - "RP101 [(E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU)], which supports apoptosis and prevents the acquisition of chemoresistance, was tested in cultured human pancreatic tumor cells. " 06/01/2003 - "[18F]5-fluoro-2-deoxyuridine-PET for imaging of malignant tumors and for measuring tissue proliferation."
2.	Glioma (Gliomas) 01/01/1997 - "A promising new treatment for glioma involves Auger electron emitters such as 125I or 123I conjugated to deoxyuridine (IUdR). " 07/30/2014 - "Concomitant inhibition of de novo thymidine synthesis with fluorodeoxyuridine and treatment with the Auger electron emitting thymidine analogue 5-[I-125]-Iodo-4'-thio-2'-deoxyuridine ([I-125]ITdU) leads to a fatal nano-irradiation in sensitized glioma stem cells. " 07/01/1998 - "The uptake of [125I]FIAU in D-247 MG human glioma cells in vitro was 20-fold higher than that of [125I]IUdR over an activity concentration range of 5-100 kBq/mL; the uptake of FAAU was not significantly different from that of 5-[211At]astato-2'-deoxyuridine (AUdR). "
3.	Rhabdomyosarcoma 11/01/2004 - "To assess the therapeutic potential of methotrexate (MTX) and 5-[1251]liodo-2'-deoxyuridine (125IdUrd) administered sequentially in rats bearing advanced (ten-day-old) intrathecal (i.t.) TE671 human rhabdomyosarcoma tumours. " 01/01/2000 - "We examined whether the administration of methotrexate (MTX) prior to the injection of 5-[125I]iodo-2'-deoxyuridine (125IUdR) in rats with intrathecal (i.t.) TE-671 human rhabdomyosarcoma would enhance 125IUdR uptake by tumor cells and augment the therapeutic efficacy of this Auger-electron-emitting radiopharmaceutical. "
4.	Ischemia 06/01/2009 - "Functional neurologic outcome (range 0-18; 0 = no deficit), cerebral infarct size (Nissl staining), and apoptosis (Terminal deoxynucleotidyl transferase-mediated 2'-deoxyuridine 5'-triphosphate nick-end labeling; cleaved caspase-3 staining) were evaluated at 3, 7, and 14 days after ischemia. " 08/17/1998 - "TUNEL (terminal deoxynucleotidyltransferase-mediated 2'-deoxyuridine 5'-triphosphate-biotin nick end labeling) staining revealed that IL-3 infusion caused a significant reduction in the number of CA1 neurons exhibiting DNA fragmentation 7 d after ischemia. "
5.	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell) 02/01/1998 - "In this report we describe results of experiments testing the efficacy of 5-[125I]-iodo-2'-deoxyuridine (125IdU) for purging murine RAW117 large cell lymphoma cells (Joshi et al., Oncology 44, 180-185, 1987; Cancer Res. 47, 3551-3557, 1987) from bone marrow in a relevant animal model. "

Related Drugs and Biologics

1.	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)
2.	triphosphoric acid (triphosphate)
3.	Idoxuridine (Stoxil)
4.	Thymidine Kinase
5.	Methotrexate (Mexate)
6.	Biotin (Vitamin H)
7.	Arabinofuranosyluracil (Ara U)
8.	Ganciclovir (Cytovene)
9.	Interleukin-3 (Interleukin 3)
10.	Acetylmuramyl-Alanyl-Isoglutamine

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Injections
3.	Adrenalectomy
4.	Radiotherapy
5.	Heterologous Transplantation (Xenotransplantation)