Deoxyribonucleases (DNase)

01/01/2012 - "Intrapleural t-PA-DNase therapy improved fluid drainage in patients with pleural infection and reduced the frequency of surgical referral and the duration of hospital stay. "
12/20/2011 - "Intrapleural t-PA plus DNase improved clinical outcomes in patients with pleural infection."
08/11/2011 - "Intrapleural t-PA-DNase therapy improved fluid drainage in patients with pleural infection and reduced the frequency of surgical referral and the duration of the hospital stay. "
11/01/2015 - "Deletion of sda1 or all DNase genes in M1T1 strain MGAS2221 did not alter emergence of CovRS mutants during murine infection. "
07/10/2015 - "Disassembling bacterial extracellular matrix with DNase-coated nanoparticles to enhance antibiotic delivery in biofilm infections."

01/01/2001 - "Efficacy of human recombinant DNase in pediatric patients with cystic fibrosis."
03/01/2000 - "Short-term clinical trials with DNase have shown minor to moderate benefits in cystic fibrosis patients. "
01/01/1999 - "The aim of this study was to investigate how DNase can be targeted to those cystic fibrosis patients who would benefit most. "
01/01/1999 - "Recombinant DNase in cystic fibrosis: a protocol for targeted introduction through n-of-1 trials. "
10/01/1995 - "DNase trials in cystic fibrosis."

07/01/2005 - "This study is devoted to the analysis of DNase activity and DNA fragmentation level in liver cells nuclei of rats with transplanted Guerin's carcinoma on irradiation background. "
01/01/1991 - "We conclude that serum alkaline DNase activity seems to have little to offer in predicting the effects of treatment in stage I and stage II cervical carcinoma."
01/01/1991 - "The objective was to evaluate if variations in serum alkaline DNase activity (SADA) can predict the effects of therapy in women with early stages of primary cervical carcinoma. "
01/01/1991 - "Initial experiences with serum alkaline DNase activity in monitoring the effects of therapy for carcinoma of the uterine cervix."
12/01/1985 - "We have isolated and purified, with good yields, nuclear envelopes from an androgen-responsive and from two androgen-unresponsive cell lines of the Shionogi mouse mammary carcinoma after subjecting purified nuclei to DNase at high pH and characterized them morphologically, chemically, and enzymatically. "

08/01/2011 - "The first intrapleural therapies proposed focused on the use of fibrinolytics and DNase to promote fluid drainage in empyema. "
07/01/2004 - "Comprehensive descriptions of the bacteriology of empyema aids antibiotic choice, and the use of intrapleural DNase shows promise in facilitating drainage of infected pleural fluid. "
06/01/2015 - "The combination of tissue plasminogen activator (tPA) and DNase was effective in animal model experiments of empyema. "
11/01/2006 - "The aim of this study was to investigate the effectiveness of intrapleural heparin or heparin combined with human recombinant DNase in the treatment of empyema. "
06/01/2014 - "Intrapleural tissue plasminogen activator (tPA) and deoxyribonuclease (DNase) therapy is being increasingly employed as an alternative to surgical intervention for the treatment of complicated parapneumonic effusions and empyema. "

01/01/1997 - "Subsequent flow cytometry experiments demonstrated that the 2C5 antibody recognizes nucleosomes on the surface of mouse EL4 T-lymphoma cells because antibody binding could be eliminated by pretreatment of these cells with DNase or heparin and approximately 10-fold increased after preincubation of cells with nucleosomes. "
05/01/2003 - "We subjected plasma/serum samples of nasopharyngeal carcinoma and lymphoma patients to DNase digestion and ultracentrifugation and showed that circulating EBV DNA molecules are "naked" DNA fragments instead of being contained inside virions. "
12/01/1969 - "This DNA effect was eliminated by DNase but not by RNase and was not induced by DNA preparations of transplanted epitheliomas or the induced lymphomas. "
07/01/1985 - "Poly ADP-ribosylation of two mouse lymphoma cell lines, L5178Y (LS) and the radiation and alkylating agent resistant derivative AII, was investigated by uptake of [3H]NAD by permeabilised cells into acid-precipitable material that was sensitive to phosphodiesterase but insensitive to DNase and RNase. "
01/01/2014 - "DNase expression is modulated in such diseases as acute myocardial infarction, transient myocardial ischemia, oral cancer, stomach cancer, and malignant lymphoma, and DNase I is used in cystic fibroma therapy. "