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Deoxycholic Acid (Sodium Deoxycholate)

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A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.

Also Known As:

Sodium Deoxycholate; Choleic Acid; Deoxycholic Acid, 12beta-Isomer; Deoxycholic Acid, 3beta-Isomer; Deoxycholic Acid, 5alpha-Isomer; Deoxycholic Acid, Disodium Salt; Deoxycholic Acid, Magnesium (2:1) Salt; Deoxycholic Acid, Monoammonium Salt; Deoxycholic Acid, Monopotassium Salt; Deoxycholic Acid, Monosodium Salt; Deoxycholic Acid, Sodium Salt, 12beta-Isomer; Dihydroxycholanoic Acid; Lagodeoxycholic Acid; 12beta-Isomer Deoxycholic Acid; 3beta-Isomer Deoxycholic Acid; 5alpha-Isomer Deoxycholic Acid; Acid, 5alpha-Isomer Deoxycholic; Acid, Choleic; Acid, Deoxycholic; Acid, Desoxycholic; Acid, Dihydroxycholanoic; Acid, Lagodeoxycholic; Deoxycholate, Sodium; Deoxycholic Acid, 12beta Isomer; Deoxycholic Acid, 3beta Isomer; Deoxycholic Acid, 5alpha Isomer; Deoxycholate; Desoxycholic Acid; Cholan-24-oic acid, 3,12-dihydroxy-, (3alpha,5beta,12alpha)-

Networked: 627 relevant articles (27 outcomes, 53 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 56
- Steroids: 18537
  - Bile Acids and Salts: 3397
    - Cholic Acids: 8
      - Deoxycholic Acid: 627
        Ursodeoxycholic Acid: 1805
        Chenodeoxycholic Acid: 715
        deoxycholate drug combination amphotericin B: 160
        Glycodeoxycholic Acid: 68
        Taurodeoxycholic Acid: 63
        hyodeoxycholic acid: 21
        3,6-dihydroxy-7-fluorocholanoic acid: 1
        3,7-dioxocholanoic acid: 1
        1-O-(24-deoxycholyl)-2-deoxyglucopyranuronic acid
        23-nordeoxycholic acid
        3-((norbornyl-2-acetyl)amino)-7,12-dihydroxycholan-24-oic acid
        3-hydroxy-polydeoxycholic acid
        3-sulfodeoxycholic acid
        6-fluoro-3,7-dihydroxy-5-cholan-24-oic acid
        6-hydroxycholanoic acid
        6-methylmurideoxycholic acid
        7-ketodeoxycholic acid
        7-methyldeoxycholic acid
        dehydrodeoxycholic acid
        deoxycholyltyrosine
        desoxybilianic acid
        hyodeoxycholate-6-O-glucuronide
        LMWH-DOCA conjugate
        N-deoxychoylethylenediamine
  - Cholanes
    - Cholic Acids: 8
      - Deoxycholic Acid: 627
        Ursodeoxycholic Acid: 1805
        Chenodeoxycholic Acid: 715
        deoxycholate drug combination amphotericin B: 160
        Glycodeoxycholic Acid: 68
        Taurodeoxycholic Acid: 63
        hyodeoxycholic acid: 21
        3,6-dihydroxy-7-fluorocholanoic acid: 1
        3,7-dioxocholanoic acid: 1
        1-O-(24-deoxycholyl)-2-deoxyglucopyranuronic acid
        23-nordeoxycholic acid
        3-((norbornyl-2-acetyl)amino)-7,12-dihydroxycholan-24-oic acid
        3-hydroxy-polydeoxycholic acid
        3-sulfodeoxycholic acid
        6-fluoro-3,7-dihydroxy-5-cholan-24-oic acid
        6-hydroxycholanoic acid
        6-methylmurideoxycholic acid
        7-ketodeoxycholic acid
        7-methyldeoxycholic acid
        dehydrodeoxycholic acid
        deoxycholyltyrosine
        desoxybilianic acid
        hyodeoxycholate-6-O-glucuronide
        LMWH-DOCA conjugate
        N-deoxychoylethylenediamine

Experts

1.	Dowling, R H: 10 articles (05/2005 - 01/2000)
2.	Murphy, G M: 9 articles (05/2005 - 06/2000)
3.	Bernstein, Carol: 8 articles (07/2014 - 12/2002)
4.	Bernstein, Harris: 8 articles (07/2014 - 12/2002)
5.	Walsh, Thomas J: 7 articles (10/2014 - 01/2002)
6.	Payne, Claire M: 7 articles (08/2011 - 12/2002)
7.	Byun, Youngro: 6 articles (11/2012 - 04/2007)
8.	Garewal, Harinder: 6 articles (01/2009 - 12/2002)
9.	Thomas, L A: 6 articles (05/2005 - 01/2000)
10.	Veysey, M J: 6 articles (05/2005 - 09/2000)

Related Diseases

1.	Infection 12/01/2008 - "ABLC is a safe and effective broad-spectrum drug in the treatment of invasive fungal infections in patients with infection refractory to AmB deoxycholate or in patients intolerant of the same formulation. " 07/01/2013 - "Amphotericin B deoxycholate is the mainstay in the treatment of invasive fungal infections in newborns. " 09/01/2003 - "Comparison of residual infection burdens in the liver and kidneys showed that AmB-deoxycholate (0.5 mg/kg) was more effective and faster in eradicating yeast cells than polymeric formulations. " 07/01/2005 - "Nebulized liposomal AMB can be a valid approach to the treatment of this infection, with subjects showing significantly improved survival relative to that of subjects given intravenous deoxycholate AMB, as well as lower lung weights and pulmonary glucosamine levels." 08/01/2014 - "Despite the fact that deoxycholate amphotericin B was once the primary drug used for mycotic infections, its administration to children older than neonates is currently controversial because of its nephrotoxic effects. "
2.	Visceral Leishmaniasis (Kala Azar) 12/01/2005 - "In India, their efficacy against visceral leishmaniasis and shorter treatment periods compared with the conventional formulation with deoxycholate has to be counter-balanced against the very high cost. " 09/01/2008 - "Amphotericin B (AB) deoxycholate is highly effective in antimony refractory cases for the treatment of visceral leishmaniasis (VL) in Bihar. " 09/01/1996 - "We compared the tolerance and efficacy of the conventional AmB prepared with deoxycholate, AmB emulsified in Intralipid 20%, amphotericin B lipid complex (Abelcet), and liposomal AmB (AmBisome) in a murine model of visceral leishmaniasis induced by Leishmania infantum. " 05/01/1996 - "The tolerance and efficacy of amphotericin B (AmB) deoxycholate (Fungizone) were compared with those of liposomal AmB (AmBisome) in a murine model of visceral leishmaniasis induced by Leishmania infantum. " 12/01/2014 - "To evaluate the efficacy of the combination of allicin and amphotericin deoxycholate (AmB) in the chemotherapy of Leishmania infantum infection with the final aim of reducing the dose of AmB in the chemotherapy of visceral leishmaniasis. "
3.	Neoplasms (Cancer) 04/01/1986 - "Our data do not support the role of DGBR in the pathogenesis of GU, but deoxycholic acid was detected in significantly greater amounts in BIPG subjects than controls (chi 2 = 12.94, P less than 0.001) or GU subjects (none detected) and may be important in the pathogenesis of gastric stump cancer." 05/01/2010 - "In this study, we aimed to investigate (i) the transcriptional responses to deoxycholic acid (DCA) in cell lines representative of either end of the oesophageal cancer sequence, (ii) the expression of DCA-regulated genes in data charting oesophageal carcinogenesis and (iii) the impact of these genes on oesophageal inflammatory signalling. " 07/01/2015 - "This firstly reported method for deoxycholate bile acid directed synthesis of branched GNPs opens new possibilities for the production of strong NIR absorbing nanostructures for selective nano-photothermolysis of cancer cells and the further design of novel materials with customized spectral and structural properties for broader applications. " 01/01/2015 - "Dramatic improvement of proteomic analysis of zebrafish liver tumor by effective protein extraction with sodium deoxycholate and heat denaturation." 10/01/2012 - "On the other hand, tumor-promoting bile acid, deoxycholic acid (DCA), also phosphorylated ERK in SNU601 cells. "
4.	Cryptococcal Meningitis 04/01/2010 - "A patient with cryptococcal meningitis and SLE, who responded well to amphotericin deoxycholate therapy, is reported. " 07/01/1996 - "We determined the safety and efficacy of deoxycholate-amphotericin B (d-AmB) mixed with Intralipid (IL) as the initial treatment of AIDS-associated cryptococcal meningitis in a phase II, multicentre, non-comparative open study, assessing two dosages of ILd-AmB: 1 mg/kg (group A, n = 9) and 1.5 mg/kg (group B, n = 6). " 07/15/2010 - "This double-blind study, performed before the routine availability of highly active antiretroviral therapy, was designed to compare the efficacy and safety of liposomal amphotericin B to conventional amphotericin deoxycholate in patients with acquired immunodeficiency syndrome (AIDS) and acute cryptococcal meningitis. "
5.	Aspergillosis 02/01/2012 - "In this retrospective study we evaluated the impact of amphotericin B (AmB) deoxycholate inhalation prophylaxis on invasive aspergillosis (IA) in 611 allogeneic stem cell transplant (alloSCT) recipients and their tolerance of the inhalations. " 10/01/2006 - "Organ transplant recipients are at increased risk for severe invasive aspergillosis, and amphotericin deoxycholate has been the standard treatment for many years. " 11/01/2004 - "Here we examined the protective effects of administration of PTX3 alone or together with deoxycholate amphotericin B (Fungizone) or liposomal amphotericin B (AmBisome) against invasive aspergillosis in a murine model of allogeneic bone marrow transplantation. " 03/01/2004 - "We compared various amphotericin B formulations (no treatment or 0.8 mg of Fungizone [conventional deoxycholate amphotericin B] per kg of body weight, or 0.8, 4, or 8 mg of Amphocil, AmBisome, or Abelcet per kg of body weight) for treatment of systemic murine aspergillosis. " 02/01/2005 - "The results show that: (a) neutrophil activation by Aspergillus occurs through TLR signalling pathways differently affecting the oxidative and non-oxidative mechanisms of the killing machinery; (b) by diverting signalling from TLR-2 to TLR-4, liposomes of AmBisome activate neutrophils to an antifungal state while attenuating the pro-inflammatory effects of deoxycholate amphotericin B; (c) this translates in vivo to the optimization of the AmBisome therapeutic efficacy in mice with aspergillosis. "

Related Drugs and Biologics

1.	Amphotericin B (Amphotericin)
2.	liposomal amphotericin B
3.	phospholipid emulsion soybean oil (Intralipid)
4.	Bile Acids and Salts (Bile Acids)
5.	Cholesterol
6.	Cholates
7.	Micelles
8.	Liposomes (Liposome)
9.	Simvastatin (Zocor)
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
3.	Aftercare (After-Treatment)
4.	Ligation
5.	Intra-Articular Injections