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Demeclocycline (Declomycin)

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A TETRACYCLINE analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than TETRACYCLINE, it maintains effective blood levels for longer periods of time.

Also Known As:

Declomycin; AHP Brand of Demeclocycline Hydrochloride; Demeclocycline Hydrochloride; Demeclocycline Monohydrochloride; Demeclocycline, 4-epimer; Demeclocycline, Calcium (1:1) Salt; Demeclocycline, Calcium (1:2) Salt; Genopharm Brand of Demeclocycline Hydrochloride; Lederle Brand of Demeclocycline Hydrochloride; Ledermycin; Lédermycine; Wyeth Brand of Demeclocycline Hydrochloride; Hydrochloride, Demeclocycline; Monohydrochloride, Demeclocycline; Demethylchlortetracycline; 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, (4S-(4alpha,4aalpha,5aalpha,6beta,12aalpha))-

Networked: 160 relevant articles (6 outcomes, 18 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Wirth, Dennis: 2 articles (04/2015 - 09/2014)
2.	Yaroslavsky, Anna N: 2 articles (04/2015 - 01/2007)
3.	Abbott, P V: 2 articles (11/2014 - 12/2002)
4.	Wagner, A: 2 articles (02/2013 - 01/2011)
5.	Gross, P: 2 articles (02/2013 - 01/2011)
6.	Trope, M: 2 articles (02/2008 - 12/2002)
7.	Levin, L: 2 articles (02/2008 - 12/2002)
8.	Ahmed, A G: 2 articles (01/2006 - 01/2002)
9.	Brookes, G: 2 articles (01/2006 - 01/2002)
10.	Dhanjal, P: 1 article (12/2015)

Related Diseases

1.	Hyponatremia 05/15/2004 - "In patients with chronic hyponatremia, fluid restriction is the mainstay of treatment, with demeclocycline therapy reserved for use in persistent cases. " 08/15/1991 - "A double blind, placebo-controlled trial of demeclocycline treatment of polydipsia-hyponatremia in chronically psychotic patients." 01/01/2015 - "Given the ongoing nature of his hyponatremia and difficulties complying with strict fluid restriction, demeclocycline was commenced in 2014. " 12/01/2011 - "Traditionally, chronic hyponatremia has been treated with fluid restriction and demeclocycline. " 03/01/2002 - "Irreversible nephrotoxicity from demeclocycline in the treatment of hyponatremia."
2.	Infection 02/01/1961 - "Efficacy of demethylchlortetracycline in severe systemic infections. " 10/01/1970 - "Demethylchlortetracycline in the management of urologic infections." 07/16/1968 - "Comparison of two dosage schedules of demethylchlortetracycline in pulmonary infection." 12/01/1961 - "(demethylchlortetracycline) in infections of the urinary tract]." 08/01/1961 - "[Experience with demethylchlortetracycline in the treatment of urinary infections]."
3.	Inappropriate ADH Syndrome (SIADH) 12/01/2015 - "Patients receiving demeclocycline for HN secondary to SIADH must be closely monitored." 12/01/2015 - "There is a lack of clinical and economic evidence supporting the use of demeclocycline for HN secondary to SIADH. " 12/01/2015 - "There has been no systematic evaluation of the use of demeclocycline for the treatment of HN secondary to SIADH to date. " 12/01/2015 - "Evidence for the use of demeclocycline in the treatment of hyponatraemia secondary to SIADH: a systematic review." 12/01/2011 - "SIADH treatment is based on water restriction and demeclocycline. "
4.	Vomiting 02/01/1999 - "We administered demeclocycline to 8 schizophrenic patients with psychiatric polydipsia, and noticed improvement in incontinence, vomiting and hyponatremia. "
5.	Skull Fractures (Skull Fracture) 01/01/1979 - "A 68-year-old patient with the syndrome of inappropriate antidiuretic hormone secretion secondary to basilary skull fracture was treated successfully with demeclocycline and phenytoin. "

Related Drugs and Biologics

1.	Hormones
2.	Lithium
3.	Furosemide (Lasix)
4.	Vasopressins (Vasopressin)
5.	Phenytoin (Dilantin)
6.	Tetracycline (Achromycin)
7.	Demeclocycline (Declomycin)
8.	Chlortetracycline (Aureomycin)
9.	Naloxone (Narcan)
10.	Doxycycline (Vibramycin)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)