Demeclocycline (Declomycin)

A TETRACYCLINE analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.

Also Known As:

Declomycin; Demeclocycline Hydrochloride; Demeclocycline Monohydrochloride; Demeclocycline, 4-epimer; Demeclocycline, Calcium (1:1) Salt; Demeclocycline, Calcium (1:2) Salt; Ledermycin; Lédermycine; Hydrochloride, Demeclocycline; Monohydrochloride, Demeclocycline; Demethylchlortetracycline; 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, (4S-(4alpha,4aalpha,5aalpha,6beta,12aalpha))-

Networked: 192 relevant articles (6 outcomes, 21 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Wirth, Dennis: 2 articles (04/2015 - 09/2014)
2.	Yaroslavsky, Anna N: 2 articles (04/2015 - 01/2007)
3.	Abbott, P V: 2 articles (11/2014 - 12/2002)
4.	Gross, P: 2 articles (02/2013 - 01/2011)
5.	Wagner, A: 2 articles (02/2013 - 01/2011)
6.	Levin, L: 2 articles (02/2008 - 12/2002)
7.	Trope, M: 2 articles (02/2008 - 12/2002)
8.	Ahmed, A G: 2 articles (10/2006 - 01/2002)
9.	Brookes, G: 2 articles (10/2006 - 01/2002)
10.	Hirata, Michinari: 1 article (01/2022)

Related Diseases

1.	Hyponatremia 12/18/2019 - "Long-term Use of Demeclocycline for the Treatment of Chronic Hyponatremia." 01/17/2019 - "The hyponatremia failed to respond to fluid restriction and demeclocycline. " 01/01/2015 - "Given the ongoing nature of his hyponatremia and difficulties complying with strict fluid restriction, demeclocycline was commenced in 2014. " 12/01/2011 - "Traditionally, chronic hyponatremia has been treated with fluid restriction and demeclocycline. " 07/01/2006 - "Chronic hyponatremia is managed with fluid restriction and demeclocycline for unresponsive cases. "
2.	Polydipsia 02/01/1999 - "[Effects of demeclocycline on psychiatric polydipsia in schizophrenic patients]." 08/15/1991 - "A double blind, placebo-controlled trial of demeclocycline treatment of polydipsia-hyponatremia in chronically psychotic patients." 02/01/1999 - "We administered demeclocycline to 8 schizophrenic patients with psychiatric polydipsia, and noticed improvement in incontinence, vomiting and hyponatremia. " 01/01/1988 - "The use of demeclocycline in the treatment of patients with psychosis, intermittent hyponatremia, and polydipsia (PIP syndrome)." 02/01/1999 - "A case was reported stating that demeclocycline, used in case where there is the syndrome of inappropriate secretion of antidiuretic hormone (SIADH), was effective for the treatment of psychiatric polydipsia. "
3.	Infections 02/01/1961 - "Efficacy of demethylchlortetracycline in severe systemic infections. " 01/01/2020 - "acnes from periprosthetic shoulder infections in vitro, with demeclocycline having the most pronounced effect." 10/01/1970 - "Demethylchlortetracycline in the management of urologic infections." 07/16/1968 - "Comparison of two dosage schedules of demethylchlortetracycline in pulmonary infection." 12/01/1961 - "(demethylchlortetracycline) in infections of the urinary tract]."
4.	Inappropriate ADH Syndrome (SIADH) 12/01/2015 - "Patients receiving demeclocycline for HN secondary to SIADH must be closely monitored." 12/01/2015 - "There is a lack of clinical and economic evidence supporting the use of demeclocycline for HN secondary to SIADH. " 12/01/2015 - "There has been no systematic evaluation of the use of demeclocycline for the treatment of HN secondary to SIADH to date. " 12/01/2015 - "Evidence for the use of demeclocycline in the treatment of hyponatraemia secondary to SIADH: a systematic review." 12/01/2011 - "SIADH treatment is based on water restriction and demeclocycline. "
5.	Vomiting 02/01/1999 - "We administered demeclocycline to 8 schizophrenic patients with psychiatric polydipsia, and noticed improvement in incontinence, vomiting and hyponatremia. "

Related Drugs and Biologics

1.	Vasopressins (Vasopressin)
2.	Lithium
3.	Furosemide (Lasix)
4.	Phenytoin (Dilantin)
5.	Tetracycline (Achromycin)
6.	Demeclocycline (Declomycin)
7.	Chlortetracycline (Aureomycin)
8.	Anti-Bacterial Agents (Antibiotics)
9.	Opiate Alkaloids
10.	Naloxone (Narcan)

Related Therapies and Procedures

1.	Therapeutics
2.	Intravenous Administration
3.	Length of Stay
4.	Drug Therapy (Chemotherapy)