Deficiency Diseases (Deficiency Disease)

A condition produced by dietary or metabolic deficiency. The term includes all diseases caused by an insufficient supply of essential nutrients, i.e., protein (or amino acids), vitamins, and minerals. It also includes an inadequacy of calories. (From Dorland, 27th ed; Stedman, 25th ed)

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Networked: 410 relevant articles (7 outcomes, 19 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Leukemia
2.	Schizophrenia (Dementia Praecox)
3.	Arthritis (Polyarthritis)
4.	Neoplasms (Cancer)
5.	Arthralgia (Joint Pain)

Experts

1.	Rhodes, Simon J: 8 articles (02/2013 - 01/2002)
2.	Berger, Melvin: 5 articles (01/2014 - 05/2006)
3.	Colvin, Stephanie C: 5 articles (02/2013 - 02/2007)
4.	Mullen, Rachel D: 3 articles (01/2009 - 02/2007)
5.	Savage, Jesse J: 3 articles (07/2007 - 03/2005)
6.	Bilezikian, John P: 2 articles (01/2015 - 06/2012)
7.	Rubin, Mishaela R: 2 articles (01/2015 - 06/2012)
8.	Cusano, Natalie E: 2 articles (01/2015 - 06/2012)
9.	Gelfand, Erwin W: 2 articles (04/2013 - 03/2005)
10.	Ochs, Hans D: 2 articles (04/2013 - 05/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Deficiency Diseases:

1.	Immunoglobulins (Immunoglobulin)IBA 12/01/1994 - "At present, the mainstay of treatment is intravenous immunoglobulin, but experimental methods have shown that other in vivo methods might ultimately be found to ameliorate this immune deficiency disease." 03/01/2005 - "Immunoglobulin replacement therapy in primary antibody deficiency diseases--maximizing success." 01/01/1993 - "Decreased levels of germline transcripts were found in immunoglobulin deficiency diseases. " 04/01/1981 - "While the number of discriminating markers for pre-B cells is still limited, examination of bone marrow pre-B cells containing cytoplasmic mu chains but lacking surface immunoglobulin has already revealed an informative spectrum of early differentiation defects in antibody deficiency diseases and malignancies of B lineage." 08/18/1977 - "Marshak has emphasized the role of the gastrointestinal tract as a major immunologic organ and described the radiologic findings of immunoglobulin deficiency diseases of the small intestine. "
2.	Neprilysin (Neutral Endopeptidase)IBA 01/01/1982 - "It is proposed the enkephalinase inhibitors may be effective in a number of human "endorphin deficiency diseases" such as depression, schizophrenia, convulsive disorders and arthritis. "
3.	Niacinamide (Nicotinamide)FDA LinkGeneric 08/25/1968 - "Prevention and remission by adrenocortical steriods of nicotinamide deficiency disease. "
4.	Monoamine Oxidase (MAO)IBA 01/01/1989 - "Some of the clinical features of these MAO deletion patients may help to identify X-linked MAO deficiency diseases in humans."
5.	Iduronic Acid (Iduronate)IBA 11/01/2009 - "The efficacy of hematopoietic stem cell transplantation (HSCT) for Hunter disease (deficiency of iduronate-2-sulfatase, IDS) remains unclear. "
6.	HydrogenIBA 07/01/2012 - "The P deficiency disease could be cured with supplement of disodium hydrogen phosphate (Na(2)HPO(4)). "
7.	EndorphinsIBA 01/01/1982 - "It is proposed the enkephalinase inhibitors may be effective in a number of human "endorphin deficiency diseases" such as depression, schizophrenia, convulsive disorders and arthritis. "
8.	IodineIBA 11/01/2005 - "Cross-sectional, observational study designed and performed according to surveillance methods for iodine deficiency disease (IDD) prevalence recommended by WHO/UNICEF/ICCIDD. " 09/01/2014 - "[Distribution iodine deficiency diseases in coastal areas depending on geochemical conditions]." 01/01/2011 - "Eastern Nepal is continuously progressing towards the sustainable elimination of iodine deficiency disease as illustrated by a normal median UIE and the majority of households consuming adequately iodized packet salt. " 01/01/2010 - "[Prevention of iodine deficiency diseases in pregnant and lactating women]." 11/01/2009 - "The age distribution of iodine-deficiency diseases in the district is characteristic of the whole city. "
9.	IronIBA 11/14/1953 - "[Pathological and clinical study of asiderosis (iron deficiency disease)]." 09/15/2013 - "Supplementation with iron-fortified foods is an effective method for treating iron deficiency diseases. " 01/01/2006 - "Iron deficiency anaemia is a very well known concept but what is often not appreciated is the effect of broad canvas of iron deficiency on various tissues, organs and systems in our body in addition to iron deficiency anaemia leading to concept of "Iron deficiency disease". " 01/01/1999 - "Anaemia and iron deficiency disease in children." 07/01/1988 - "Iron deficiency disease."
10.	HormonesIBA 01/01/2009 - "Recent studies have identified a variety of mutations in the LHX3 and LHX4 genes in patients with combined pituitary hormone deficiency diseases. " 02/01/2013 - "Together, these data show that hormone deficiency disease is apparent in early prenatal stages in this CPHD model system. " 02/01/2013 - "Developmental analysis and influence of genetic background on the Lhx3 W227ter mouse model of combined pituitary hormone deficiency disease." 01/04/2011 - "The etiology of most pediatric hormone deficiency diseases is poorly understood. " 09/01/2009 - "Menopause, having been constructed as a deficiency disease, required initially chemical hormone replacement and now bio-identical hormones replacing the mainstream medical solution. "

Therapies and Procedures

1.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 10/01/1993 - "The effectiveness of bone marrow transplantation for treating lysosomal deficiency diseases relies on the ability of bone marrow cells to provide the missing enzyme to various tissues of the recipient. " 05/01/1991 - "Between 1975 and 1988, 92 pediatric patients have undergone bone marrow transplantation (BMT) at our institution for malignant or immune deficiency disease. " 06/01/1986 - "Long-term immunological reconstitution by peripheral blood leucocytes in severe combined immune deficiency disease: implications for the role of mature lymphocytes in histocompatible bone marrow transplantation." 03/01/1979 - "Bone marrow transplantation for correction of enzyme deficiency disease." 11/04/1972 - "[Bone marrow transplantation in immune deficiency disease]."
2.	Hematopoietic Stem Cell Transplantation 11/01/2009 - "The efficacy of hematopoietic stem cell transplantation (HSCT) for Hunter disease (deficiency of iduronate-2-sulfatase, IDS) remains unclear. "
3.	Transplants (Transplant) 08/01/2002 - "The first successful transplants of hematopoietic stem cells were done in 1968 in three children with congenital immune deficiency diseases. " 01/01/1972 - "Use and abuse of hemopoietic cell grafts in immune deficiency diseases." 01/01/1999 - "Even though the study of the THCs promotes a great number of questions about the basic mechanisms that regulate them, in several laboratories in the world a new aspect of research: their use in transplants, using THCs as a substitute for whole bone marrow transplant and, still in the initial stages, their use as targets for gene therapy for deficiency diseases or even for therapy against cancer." 03/01/1969 - "Graft versus host reaction in Wiskott-Aldrich syndrome: antemortem diagnosis of human GVH in an immunologic deficiency disease." 09/01/1989 - "A total of 10,887 patients received bone marrow transplants; 73% were for leukemia, 11% for other malignant diseases, 9% for severe aplastic anemia and related disorders, 3% for immune deficiency diseases, 2% for thalassemia major, and 2% for genetic, metabolic, and several other rare diseases. "
4.	Immunotherapy 11/01/1995 - "The design and outcome of the genetic modification strategies employed are reviewed for 16 marking trials, 16 gene replacement trials for molecular deficiency diseases, 3 chemoprotection and 4 chemotherapy sensitization trials, 11 cancer vaccine trials, 2 antisense oligonucleotide trials, and 3 molecular immunotherapy trials. " 10/01/2000 - "Thus NST may become the optimal approach for the treatment of nonmalignant diseases, where replacement of host with donor hematopoietic cells is indicated: for correction of genetic or stem cell deficiency diseases; as a platform for immunotherapy of autoimmune or infectious diseases; or for induction of tolerance to organ allografts."
5.	Drug Therapy (Chemotherapy) 11/01/1995 - "The design and outcome of the genetic modification strategies employed are reviewed for 16 marking trials, 16 gene replacement trials for molecular deficiency diseases, 3 chemoprotection and 4 chemotherapy sensitization trials, 11 cancer vaccine trials, 2 antisense oligonucleotide trials, and 3 molecular immunotherapy trials. " 06/01/1982 - "A review of the medical literature indicated that low-birth weight infants and patients with leukemia and other malignancies undergoing chemotherapy, splenectomy, congenital asplenia, sickle cell anemia, immunoglobulin deficiency diseases, cerebrospinal fluid shunts, and skull defects are at greater risk for systemic H. "