Decerebrate State

A condition characterized by abnormal posturing of the limbs that is associated with injury to the brainstem. This may occur as a clinical manifestation or induced experimentally in animals. The extensor reflexes are exaggerated leading to rigid extension of the limbs accompanied by hyperreflexia and opisthotonus. This condition is usually caused by lesions which occur in the region of the brainstem that lies between the red nuclei and the vestibular nuclei. In contrast, decorticate rigidity is characterized by flexion of the elbows and wrists with extension of the legs and feet. The causative lesion for this condition is located above the red nuclei and usually consists of diffuse cerebral damage. (From Adams et al., Principles of Neurology, 6th ed, p358)
Also Known As:
Decerebrate Posturings; Decerebrate Rigidity; Decerebrate States; Decorticate Rigidities; Decorticate States; Posturing, Decerebrate; Posturings, Decerebrate; Rigidities, Decorticate; State, Decerebrate; States, Decerebrate; Decerebrate Posturing; Decorticate Rigidity; Decorticate State; Rigidity, Decerebrate; Rigidity, Decorticate
Networked: 64 relevant articles (4 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Fever (Fevers)
2. Brain Hypoxia (Cerebral Hypoxia)
3. Heart Arrest (Cardiac Arrest)
4. Coma (Comas)
5. Ventricular Fibrillation


1. Kao, Chuen-Der: 2 articles (01/2008 - 11/2004)
2. Liao, Kwong-Kum: 2 articles (01/2008 - 11/2004)
3. Chen, Jen-Tse: 2 articles (01/2008 - 11/2004)
4. Wu, Zin-An: 2 articles (01/2008 - 11/2004)
5. Chang, Jiun-Bin: 2 articles (01/2008 - 11/2004)
6. Ichikawa, Kazushi: 1 article (12/2013)
7. Oyama, Yoshitaka: 1 article (12/2013)
8. Watanabe, Yoshihiro: 1 article (12/2013)
9. Motoi, Hirotaka: 1 article (12/2013)
10. Takeshita, Saoko: 1 article (12/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Decerebrate State:
1. Oxazolidinones (2 Oxazolidone)IBA
2. Norepinephrine (Noradrenaline)FDA LinkGeneric
01/01/1988 - "1. The effects of a noradrenaline precursor, L-threo-3,4-dihydroxyphenylserine (L-DOPS), on spinal mono-(MSR) and polysynaptic reflexes (PSR) and decerebrate rigidity, were studied. "
01/01/1995 - "We studied the effects of adrenergic drugs on spinal reflexes, decerebrate rigidity, and noradrenaline release from the spinal cord in rats, and motoneuron activity in spinal cord slices isolated from adult rats. "
03/01/1974 - "It is likely that these drugs reduce decerebrate rigidity by inhibiting fusimotor activity.5 Desipramine increased decerebrate rigidity and increased spindle afferent discharge.6 It is thought that the phenothiazine derivatives studied reduce decerebrate rigidity and spindle afferent discharge by inhibiting receptors for noradrenaline in the central nervous system."
03/01/1974 - "M & B 18,706 was also eight times as potent as (+)-M & B 18,706 in reducing the pressor action of noradrenaline and six times as potent in reducing decerebrate rigidity.3 For the above compounds and chlorpromazine there was a significant correlation between the effective doses for the inhibition of the pressor action of noradrenaline and for the reduction of decerebrate rigidity.4 The doses which reduced decerebrate rigidity were similar to those that reduced muscle spindle afferent discharge. "
03/01/1974 - "1 The relative potencies of methotrimeprazine, (+)-methotrimeprazine, (+/-)-10-(3-dimethylamino-2-methylpropyl)-2-valeroyl phenothiazine hydrochloride (M & B 18,706) and (+)-M & B 18,706 in reducing the pressor action of noradrenaline in the spinal cat, reducing intercollicular decerebrate rigidity, and muscle spindle afferent activity have been studied.2 Methotrimeprazine was eight times as potent as (+)-methotrimeprazine in reducing the pressor action of noradrenaline and six times as potent in reducing decerebrate rigidity. "
3. Propranolol (Inderal)FDA LinkGeneric
4. TremorineIBA
5. StrychnineIBA
6. Kynurenic Acid (Kynurenate)IBA
7. KetamineFDA LinkGeneric
8. Hexobarbital (Hexenal)IBA
9. Epinephrine (Adrenaline)FDA LinkGeneric
10. 3- (2- carboxypiperazin- 4- yl)propyl- 1- phosphonic acid (CPP)IBA

Therapies and Procedures

1. Electroacupuncture
2. Resuscitation
3. Intra-Arterial Injections
4. Epidural Injections
5. Renal Replacement Therapy (Therapies, Renal Replacement)