Sudden Death

09/01/1992 - "Treatment using anti-arrhythmic drugs is most often effective and, with proper management, the prognosis is good and the risk of sudden death eliminated. "
06/04/1992 - "Antiarrhythmic drugs have not been shown to be effective for preventing sudden death, although there are as yet no well-controlled randomized trials. "
11/01/1992 - "Several trials investigating the efficacy of antiarrhythmic drugs in decreasing sudden death have yielded disappointing results. "
07/01/1979 - "Thus, it may serve as a model to study sudden death and the efficacy of antiarrhythmic drugs."
09/01/2002 - "The efficacy of antiarrhythmic drugs and devices in preventing sudden death and reducing total mortality is uncertain. "

01/01/2018 - "Amiodarone is effective in reducing ventricular arrhythmias, but there is no evidence for hard endpoints (sudden death, hospitalization). "
04/01/1994 - "beta-Blockers and amiodarone are effective in primary prevention of sudden death in selected populations. "
05/01/2007 - "The object of this study was to determine the incidence, dose, and time until onset of bilateral vision loss from amiodarone as a secondary end point in an investigation of amiodarone's role in preventing sudden death. "
05/01/1999 - "Assuming NSVT as a potential prognostic marker for sudden death, amiodarone treatment may have exerted a beneficial effect in these patients, but this statement is only a presumption due to the limitations of our study. "
03/11/1999 - "Several trials have evaluated the role of amiodarone in decreasing mortality in patients at high risk of developing sudden death. "

11/01/1981 - "Pretreatment with aspirin, which uniformly inhibited platelet aggregation, was associated with a reduced incidence of sudden death (25%), but the difference between aspirin-treated and control animals lacked statistical significance. "
01/01/2018 - "Stratification by body size also revealed harms due to excess dosing: risk of sudden death was increased by aspirin in people at low weight for dose (pinteraction=0·0018) and risk of all-cause death was increased in people weighing less than 50 kg who were receiving 75-100 mg aspirin (HR 1·52 [95% CI 1·04-2·21], p=0·031). "
10/01/2017 - "Aspirin is known to interfere with platelet function and can protect individuals at risk of sudden death. "
05/01/2010 - "Detecting an interaction between acetylsalicylic acid and PF4-H-ABs regarding sudden death and mortality, we found that the association between PF4-H-ABs and outcomes was restricted to patients with acetylsalicylic acid use, most likely because of indication bias. "
09/14/2018 - "The gold standard treatment to manage CHD is aspirin, which may prevent myocardial infarction and sudden death; however, long-term use of aspirin may increase its side effects. "

02/01/2011 - "The goal of this study was to determine the mechanisms of n-3 polyunsaturated fatty acids (n-3 PUFA) on anti-arrhythmias and prevention of sudden death. "
04/01/2010 - "Risk of sudden death is associated with a low blood level of n-3 polyunsaturated fatty acids. "
06/03/2003 - "The fish story: a diet-heart hypothesis with clinical implications: n-3 polyunsaturated fatty acids, myocardial vulnerability, and sudden death."
12/01/2002 - "Effect of n-3 polyunsaturated fatty acids on risk reduction of sudden death."
12/01/2006 - "The use of highly concentrated and purified omega-3 polyunsaturated fatty acids (n-3 PUFAs), in addition to standard secondary prevention after MI, results in a significant reduction in the risk of sudden death. "

08/01/2003 - "Emphasis on foods rich in n-3 fatty acids shows promise for reducing cardiovascular outcomes, particularly sudden death."
09/01/2002 - "However, we believe that large-scale prospective multicentric randomized trials aimed at preventing sudden death in high-risk patients as well as at testing the effects of n-3 PUFA in patients with intracoronary devices and sustained ventricular arrhythmias, are a major direction to be followed to better understand the n-3 PUFA and sudden death issue."
03/01/2002 - "The hypothesis that a protection from sudden death occurs because of antiarrhythmic effects of omega-3 fatty acids is supported by studies on cellular and animal models. "
06/01/2013 - "Recent randomized evidence indeed fails to support that n-3 fatty acids may prevent sudden death in nonrenal patients. "
08/15/2011 - "The antiarrhythmic effect of omega-3 fatty acids may be particularly crucial for these men at greatest risk for sudden death. "

11/01/1978 - "All patients with this disorder should be treated with propranolol; surgical intervention, although it does not totally abolish the risk of sudden death, appears to offer symptomatic improvement in most cases over a long-term follow-up period."
06/01/1982 - "Nineteen of the 78 patients (24%) were taking propranolol in apparently adequate dosages, indicating that this drug does not provide absolute protection against sudden death. "
02/01/1998 - "The results of the Cox regression analysis, adjusting for all baseline variables with p values <0.25, showed the relative risk of overall mortality rate and the relative risk of sudden death were 2.13 ( 1.22, 3.70) and 2.56 (1.27, 5.26), respectively, for the placebo group compared with the propranolol group. "
02/01/1998 - "Sudden death in the placebo arm was 9.7% compared with 4.7% in the propranolol group (p = 0.012, log rank test). "
07/15/1990 - "Mortality was 7.8% (sudden death 4.8%) in the propranolol group and 7.9% (sudden death 4.8%) in the placebo group (p greater than 0.99, log rank test). "

10/01/2003 - "Metoprolol CR/XL reduced total mortality by 40% (95% CI 0.20-0.55, P =.0004), and sudden death by 50% (95% CI 0.26-0.66, P =.0004). "
03/01/1998 - "Although the starting dose of metoprolol, the most common beta-blocker used, may have to be as low as 2.5 mg/d, mortality analysis failed to show a decrease in sudden death unless the dose was raised to about 300 mg/d, a dose at which beta-selectivity is generally not expected to be present. "
10/01/1988 - "In the metoprolol group there was one sudden death and two drop-outs.(ABSTRACT TRUNCATED AT 250 WORDS)"
06/01/1985 - "Sudden death rates were 14.7% in the placebo versus 5.8% in the metoprolol group (p less than 0.05). "
03/01/1985 - "Sudden death occurred less frequently in patients allocated to metoprolol but there was no significant difference in total mortality on discharge, at three months and at twelve months. "

01/15/2007 - "This may explain the contradictory outcomes of increased intake of fish oil on sudden death and arrhythmias in clinical trials. "
05/01/2007 - "Increased fish or fish-oil consumption is associated with reduced risk of cardiac mortality, especially sudden death. "
09/01/2006 - "Strategies improving awareness of fish oil's effects on sudden death and reducing time barriers associated with dietary counseling should be explored further to increase recommendation of this important advice."
09/01/2006 - "Knowledge of fish oil's benefit in sudden death reduction was associated with higher fish prescribers in bivariate (P = .005) and multivariate analysis (OR = 2.77; 95th CI: 1.32 to 5.82). "
09/27/2005 - "The effect of fish oil on heart rate (HR), a major risk factor for sudden death, is not well established. "

08/01/2015 - "Lipid core detection using NIRS may help to identify vulnerable plaques to treat them before they cause ACS or sudden death. "
07/02/2003 - "Randomized trials of lipid-lowering drugs suggest reduction of sudden death (SD) in patients with ASHD. "
08/01/2015 - "An intracoronary imaging device to detect lipid-rich plaques (LRPs) could therefore identify most of the plaques causing ACS and sudden death. "
12/20/2011 - "It is difficult to distinguish the contribution of cardiomyocyte lipid accumulation from the contribution of global metabolic defects to the increased incidence of sudden death and electric abnormalities. "
12/01/1997 - "Postmortem lipid levels for the analysis of risk factors of sudden death: usefulness of the Ektachem and Monarch analyzers."

12/01/1980 - "In multivariate Cox regression, controlling for age, blood pressure, serum cholesterol, cigarettes smoked per day and relative weight, heart rate is a significant risk factor for sudden CHD death and non-CVD death in two of the three studies, with the association with sudden death being U-shaped in one of the studies. "
05/01/2013 - "Increased LCAT activity measured as a serum cholesterol esterification rate was a risk for CHD and sudden death in a Japanese general population."
04/20/1999 - "Resting heart rate, systolic or diastolic blood pressure, tobacco consumption, body mass index, diabetes status, serum cholesterol, and parental history of sudden death were independent factors associated with sudden death during follow-up (23 years on average). "
12/01/1990 - "In asymptomatic persons the risk of sudden death varies over a wide range in relation to risk factors such as systolic blood pressure, serum cholesterol, cigarette smoking, heart rate, electrocardiographic abnormality and relative weight. "
11/01/2017 - "A risk score of sudden death in 5 years was built with seven significant risk factors: age, sex, SBP, serum total cholesterol, cigarette smoking, diabetes, and history of myocardial infarction. "

07/01/2010 - "This issue has acquired even greater relevance since implantable cardioverter-defibrillators have proved to be highly effective in preventing sudden death in high-risk subjects. "
04/01/2009 - "Therefore, identification of those patients at high risk of sudden death represents a major clinical problem and has become an even greater challenge since the implantable cardioverter-defibrillator (ICD) has proved to be highly effective in preventing sudden death in HCM. "
12/01/2007 - "Therefore, risk stratification for sudden death has a major role in the management of HCM and has acquired even greater relevance since the implantable cardioverter-defibrillator (ICD) has proved to be highly effective in preventing sudden death in this disease. "
12/01/2004 - "The implantable cardioverter-defibrillator is the most effective treatment for sudden death prevention, and should be considered in patients with either one strong or multiple risk factors. "
03/11/1999 - "The implantable cardioverter defibrillator (ICD) is highly effective in the prevention of sudden death, but no mortality benefit in advanced CHF has yet been shown. "

06/01/2001 - "Pooled analysis revealed a statistically significant reduction in the risk of total mortality (odds ratio [OR]MH=0.66; 95% confidence interval [CI], 0.58-0.75) and sudden death (ORMH=0.61; 95% CI, 0.5-0.75) for patients receiving beta-blocker therapy. "
11/01/1991 - "ICD therapy appears effective in reducing sudden death mortality in this high risk population."
06/01/1989 - "Therapy to suppress asymptomatic PVCs has not been shown to be effective in preventing sudden death, and in some cases, lethal arrhythmias can be prevented without significant effects on ambient arrhythmias. "
12/01/2022 - "In this review, we share our experiences and progress of our research and development of our program that was designed to identify the cause of sudden death, understand pathophysiology of the syndrome, and develop effective and safe management and therapy of BrS patients. "
10/01/2003 - "The application of ICD therapy continues to expand in pediatric populations, due in part to improved technology and new indications, including the prevention of sudden death while awaiting OHT. "

03/01/2004 - "Implanted cardioverter defibrillator (ICD) is expensive but highly effective in preventing sudden death. "
01/01/2020 - "Vest Prevention of Early Sudden Death Trial did not demonstrate a significant reduction in arrhythmic death with the wearable cardioverter-defibrillator (WCD), but compliance with the device may have substantially affected the results. "
05/01/2009 - "These observations also suggest that home automatic defibrillator strategies for sudden death prevention are unlikely to be effective in HCM."
10/01/2004 - "New evidence suggests that the implantable cardiac defibrillator (ICD) may be effective for primary prevention of sudden death. "
11/01/1995 - "Transvenous cardioverter defibrillators offer effective protection against sudden death. "

01/01/1991 - "In contrast to these studies, the pooled results of major secondary prevention trials using beta-blocking agents could demonstrate a significant reduction in the sudden death rate by an average of 24% during observation periods of 9-36 months. "
09/01/2003 - "ICD is effective for secondary prevention of sudden death in HCM. "
07/01/2002 - "The implant of the AID is a safe and effective measure for primary and secondary prevention of sudden death. "
11/01/2005 - "Patients were divided into 4 groups depending on the ICD indication: groups A (secondary prevention of sudden death), B (left ventricular ejection fraction < or = 35% and positive electrophysiology study [EPS]), C (left ventricular ejection fraction < or = 35% and negative EPS or no EPS performed), and D (patients who did not meet inclusion criteria for groups A, B, or C). "
09/01/2004 - "In particular, ICD use in large primary and secondary prevention clinical trials in patients at high risk of sudden death has demonstrated that these devices improve survival. "

02/01/2013 - "Transplantations of ESC-CM DOX(-) and ESC-CM DOX(+) both significantly improved LV ejection fraction, LV end-systolic diameter, end-systolic pressure-volume relationship, and positive maximal and negative pressure derivative (P< .05) at 4 weeks compared with the MI group; however, the DOX(-) group (22 of 40, 55%) had a significantly higher early sudden death rate than the DOX(+) group (13 of 40, 32.5%; P = .036). "
09/05/2015 - "Only one patient suffered sudden death 19 months after transplantation. "
06/01/2012 - "After 12 weeks, no animal developed sudden death after the transplantation. "
02/01/2008 - "After 1.5 y of follow-up, 4 individuals had an adverse outcome (CHF death, new or recurrent sudden death, or progressive CHF leading to transplantation). "
12/12/2006 - "The first patient suffered sudden death at 20 months after transplantation at 30 years of age. "