Sudden Hearing Loss (Sudden Deafness)

Sensorineural hearing loss which develops suddenly over a period of hours or a few days. It varies in severity from mild to total deafness. Sudden deafness can be due to head trauma, vascular diseases, infections, or can appear without obvious cause or warning.

Also Known As:

Networked: 476 relevant articles (48 outcomes, 55 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Tinnitus
2.	Hearing Loss (Hearing Impairment)
3.	Macular Degeneration (Age-Related Maculopathy)
4.	Meniere Disease (Menieres Disease)
5.	Cardiomyopathies (Cardiomyopathy)

Experts

1.	Moon, In Seok: 4 articles (06/2014 - 09/2009)
2.	Nakashima, Tsutomu: 4 articles (01/2012 - 11/2002)
3.	Marco Algarra, J: 4 articles (12/2004 - 05/2000)
4.	García Callejo, F J: 4 articles (12/2004 - 05/2000)
5.	Kleinjung, Tobias: 3 articles (01/2012 - 01/2004)
6.	Scherer, Elias Q: 3 articles (11/2010 - 12/2002)
7.	Wangemann, Philine: 3 articles (11/2010 - 12/2002)
8.	Sone, Michihiko: 3 articles (06/2010 - 11/2002)
9.	Osterkorn, D: 3 articles (12/2009 - 01/2003)
10.	Osterkorn, K: 3 articles (12/2009 - 01/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Sudden Hearing Loss:

1.	Dexamethasone (Maxidex)FDA LinkGeneric 12/01/2011 - "This study aimed to investigate the therapeutic efficacy of intratympanic dexamethasone (ITD) as a salvage treatment in sudden hearing loss (SHL) patients who had no response to initial systemic combination steroid therapy. " 05/01/2008 - "The conventional drug treatment with taking dexamethasone orally or intravenous dexamethasone injection had no obvious effect on sudden deafness with PTA > 70 dB, but the conventional drug treatment with intratympanic dexamethasone injection is a useful treatment for sudden deafness. " 08/01/2015 - "Efficacy of low-dose intratympanic dexamethasone for sudden hearing loss." 05/01/2015 - "To evaluate the efficacy of intratympanic dexamethasone injection for the moderate and severe sudden deafness with BPPV. " 05/01/2015 - "[The efficacy of intratympanic dexamethasone injection for the moderate and severe sudden deafness with BPPV]."
2.	SteroidsIBA 02/01/2012 - "Are intra-tympanically administered steroids effective in patients with sudden deafness? " 05/01/2010 - "Intratympanic steroid therapy has been shown to be effective for cochleovestibular symptoms after failure of systemic steroids for sudden deafness and for control of Ménière's disease. " 12/01/1980 - "The efficacy of steroids in the treatment of idiopathic sudden hearing loss. " 12/01/2015 - "Other studies have shown NAC to have a protective adjunct role in human idiopathic sudden hearing loss, where the addition of NAC resulted in better hearing recovery than with steroids alone, although the mechanism of this protection was not elucidated. " 05/01/1984 - "Few studies have investigated the effect of steroids on idiopathic sudden hearing loss (ISHL). "
3.	OxygenIBA 03/01/2015 - "This study aims to investigate whether addition of intratympanic steroid (ITS) to systemic steroid and hyperbaric oxygen (HBO) is effective in the treatment of sudden hearing loss (SHL). " 09/01/1991 - "The results of our study were evaluated by means of standardised statistics confirming the effectiveness and even the superiority of the oxygen multistep therapy in comparison with any other treatment, and also in view of the spontaneous remission rate in cases of sudden hearing loss." 09/01/2002 - "We evaluated the efficacy of hyperbaric oxygen (HBO) treatment in patients with sudden hearing loss unresponsive to medical treatment. " 01/01/2015 - "Fifteen patients affected by sudden hearing loss and treated with hyperbaric oxygen after steroid and vasodilator therapy failed constituted the study group. " 07/01/2015 - "Hyperbaric oxygen for idiopathic sudden hearing loss: is the routine application helpful?"
4.	MethylprednisoloneFDA LinkGeneric 11/01/2013 - "Therapeutic efficacy of the combination of intratympanic methylprednisolone and oral steroid for idiopathic sudden deafness." 05/01/2015 - "Postaurical injection of methylprednisolone for the low-middle frequency sudden hearing loss is effective, safe and simple, which may be an alternative for systemic administration of gulcocorticoid." 05/01/2015 - "To evaluate the clinical efficacy on the treatment of the low-middle frequency sudden hearing loss with postaurical injection of methylprednisolone. " 05/01/2015 - "[Clinical effect on the treatment of the low-middle frequency sudden hearing loss with postaurical injection of methylprednisolone]." 01/01/2015 - "The therapy of postaural methylprednisolone injection can decrease pure tone threshold effectively and increased speech discrimination with a sudden hearing loss."
5.	Pentoxifylline (Trental)FDA LinkGeneric 04/01/1983 - "The author's method of suggestion therapy can lead to a total remission of sudden deafness or to a favourable precondition for later infusion therapy (Onkovertin with Sorbit + Trental). " 03/01/1995 - "[Clinical and electron microscopy study of sudden deafness treatment with the 10% HES 200/0.5 and pentoxifylline combination]." 01/01/1990 - "Both parameters have been checked in two groups of patients suffering from sudden deafness; one treated with Dextran-40 and Pentoxifylline, the other with Dextran-40 only. " 01/01/1992 - "It is concluded that there were, in fact, no clinically relevant differences in hearing gains of sudden hearing loss or acute acoustic trauma between treatments with saline infusions together with placebo medication and treatment with dextran-40 and/or pentoxifylline." 07/01/2001 - "In a randomized, prospective, double-blind study involving 72 patients, the therapeutic efficacy of ginkgo extract EGb 761 (n = 37) was compared to that of pentoxifylline (n = 35) for the treatment of sudden deafness. "
6.	Alprostadil (Muse)FDA LinkGeneric 05/01/2012 - "The efficacy of combined high-dose steroid and PGE1 treatment initiated immediately after the onset of sudden deafness was analyzed with the outcome of 174 patients begun on treatment within 7 days of the onset of sudden deafness. " 05/01/2012 - "[Efficacy of early combined high-dose steroid + PGE1 treatment for sudden deafness]." 05/01/2008 - "Is the application of prostaglandin E1 effective for the treatment of sudden hearing loss? " 05/01/2012 - "These results suggest that significant efficacy may be expected from the combined high-dose steroid + PGE1 treatment, if its use is started within 7 days of the onset of sudden deafness, and started within 3 days of the onset of sudden deafness in patients 50 years old and older." 10/01/2010 - "[Treating sudden deafness by intravenous injecting Alprostadil leads to acute ache of lower limbs: tow cases report]."
7.	Dextrans (Dextran)FDA Link 04/01/1976 - "The mean hearing gain (125-8,000 Hz) in 46 cases of sudden deafness treated with low molecular weight dextran was found to be significantly greater (20.9 dB) than that obtained in twelve cases treated differently (9.4 dB). " 12/01/2012 - "Treatment outcome of additional dextran to corticosteroid therapy on sudden deafness: propensity score-matched cohort analysis." 09/01/2002 - "Pulmonary complication in cases of sudden deafness after dextran treatment is rarely reported. " 05/01/1994 - "Sudden deafness: a retrospective evaluation of dextran therapy." 01/01/1986 - "After the apparition of a sudden deafness, 45 patients (22 men and 23 women, with a mean age of 44 +/- 14.9 years) were treated with normovolaemic haemodilution performed with dextran 60. "
8.	Fibrinogen (Factor I)FDA Link 05/01/2013 - "The therapeutic efficacy of flat type of sudden hearing loss overall is good; the treatment of improving the inner ear blood rheology and/or reducing blood fibrinogen has clinical significance; the therapeutic efficacy of using glucocorticoid systemically is good as well; there is no obvious difference between combination and single medication." 01/01/2004 - "Improved treatment of sudden hearing loss by specific fibrinogen aphaeresis." 01/01/2004 - "In conclusion, specific fibrinogen adsorption is a promising new treatment modality that should be tested in a prospective, randomized controlled trial in patients with sudden hearing loss." 01/01/2004 - "Elevated blood viscosity due to high fibrinogen levels is supposed to cause decreased cochlear blood flow and thus initiate sudden hearing loss. " 05/01/2002 - "More research is still required to determine the value of measuring plasma fibrinogen levels in clinical practice and identifying hyperfibrinogenemia in sudden hearing loss."
9.	Adrenal Cortex Hormones (Corticosteroids)IBA 05/01/2003 - "Older data documenting the efficacy of corticosteroids in the treatment of sudden hearing loss may need to be reevaluated, given that many of these studies were conducted before MRI was available." 01/01/2014 - "To date, no therapeutic option has been established for sudden deafness refractory to systemic corticosteroids. " 01/01/2012 - "This is a retrospective study of 96 patients with idiopathic sudden deafness referred to a tertiary centre between 2005 and 2009 treated with corticosteroids intravenously at a daily dose of 1 mg/kg. Mean tonal thresholds were assessed (PTA = [500 Hz + 1000 Hz + 2000 Hz + 4000 Hz]/4). " 02/01/2005 - "She had been diagnosed with sudden deafness and treated with corticosteroids. " 05/04/1985 - "Recovery from sudden hearing loss after prompt treatment with corticosteroids]."
10.	Nafronyl (Naftidrofuryl)IBA 11/01/1993 - "The effectiveness of adding naftidrofuryl to infusions designed to increase cochlear blood flow in cases of sudden hearing loss has been keenly debated in the otologic literature. " 01/01/1993 - "[Sudden deafness: a randomized comparative study of 2 administration modalities of hyperbaric oxygenotherapy combined with naftidrofuryl]." 12/01/1991 - "Two good comparable groups of patients (group 1 treated with 10% HES 200/0.5 + Naftidrofuryl; and group 2 treated with 6% HES 200/0.5 + Naftidrofuryl) with sudden hearing loss were compared with respect to their hearing recovery, hemorheological parameters and intravasal detectable HES fraction. " 01/01/1985 - "[Sudden deafness--on the age dependence of therapy results with reference to naftidrofuryl (Dusodril)]." 05/01/1987 - "In a prospectively randomized trial, conduced jointly by the University ENT Department, Göttingen, and the ENT Department of Zentralkrankenhaus St.-Juergen-Strasse, Bremen, the therapeutic efficiencies of naftidrofuryl and pentoxifyllin, both in combination with a basic medication (cortison, dextran), were compared in 151 patients with sudden deafness. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 05/01/2015 - "Some cases of sudden hearing loss in CML may be improved or even cured by leukapheresis and intrathecal chemotherapy. " 11/01/1996 - "Since combined pharmacotherapy has been used in the treatment of idiopathic sudden deafness, it is hard to make a quantitative analysis of single-drug efficacy. " 02/01/1993 - "Recently there was another episode of sudden deafness, associated with a rising leukocyte count, and disease activity followed once again by recovery after chemotherapy. " 01/01/1991 - "In 95 patients with unilateral sudden deafness, pure-tone and speech audiometry was performed before, during and after drug therapy. " 02/01/1983 - "[Rheologic problems of microcirculation and consequences of drug therapy for sudden deafness]."
2.	Blood Component Removal (Apheresis) 01/01/1999 - "Clinical utility of LDL-apheresis in the treatment of sudden hearing loss: a prospective, randomized study." 07/01/2011 - "Apheresis as rescue therapy in a severe case of sudden hearing loss." 12/01/2006 - "Apheresis for idiopathic sudden hearing loss: reviewing the evidence." 06/01/2006 - "Does a reduction of adhesion molecules by LDL-apheresis have a role in the treatment of sudden hearing loss?" 10/01/2001 - "The clinical impression and first controlled data make it likely that HELP apheresis is useful in the therapy of sudden hearing loss with suspected vascular origin."
3.	Injections 08/01/2005 - "A clinical trial of intratympanic injections for idiopathic sudden hearing loss was successfully completed and promising results were found." 10/01/2011 - "The authors identified 176 articles, of which 32 represented studies of initial or salvage intratympanic steroid injections for sudden hearing loss that included 6 randomized trials and only 2 randomized controlled trials. " 07/01/2010 - "Three intratympanic injections of methylprednisolone improved pure-tone average or speech discrimination scores for a subset of sudden hearing loss subjects that failed to benefit from oral steroids." 08/01/2005 - "Four intratympanic injections of methylprednisolone improved pure-tone average or speech discrimination scores for a subset of sudden hearing loss subjects that failed to benefit from oral steroids. " 01/01/2006 - "One hundred and eighty-eight SG injections in 15 patients (5 with postherpetic neuralgia and 10 with sudden deafness) were performed either with 1% mepivacaine 6 ml or with neurotropin 3 ml combined with saline 3 ml in turn. "
4.	Hyperbaric Oxygenation 09/01/2001 - "Considering the spontaneous remission of sudden deafness, neither the results of the infusion therapy nor those of the hyperbaric oxygenation surpass the rate of complete spontaneous remission. " 09/01/2014 - "Management of sudden hearing loss with hyperbaric oxygen therapy." 05/01/2012 - "Hyperbaric oxygen therapy with short duration intratympanic steroid therapy for sudden hearing loss." 06/01/2009 - "Considering the cost of hyperbaric oxygen therapy and its inconvenience to patients, this treatment should only be considered in patients suffering sudden hearing loss if there are contraindications to standard medical treatment." 06/01/2009 - "To evaluate the effectiveness of hyperbaric oxygen therapy in the management of sudden hearing loss. "
5.	Hemodilution 01/01/1998 - "Hemodilution is considered to be a useful therapy for sudden hearing loss by improving cochlear blood flow (COBF) as a result of decreasing viscosity of the whole blood. " 01/01/1991 - "[Sudden deafness: different pathologies and results of treatment by normovolemic hemodilution]." 01/01/1990 - "[Normovolemic hemodilution in the treatment of sudden deafness]." 01/01/1990 - "The aim of the rheological treatment in sudden deafness is the improvement of the microcirculation in the inner ear by hemodilution and decreased viscosity of the blood. " 01/01/1986 - "[Normovolemic hemodilution in the treatment of sudden deafness]."