DDT

A polychlorinated pesticide that is resistant to destruction by light and oxidation. Its unusual stability has resulted in difficulties in residue removal from water, soil, and foodstuffs. This substance may reasonably be anticipated to be a carcinogen: Fourth Annual Report on Carcinogens (NTP-85-002, 1985). (From Merck Index, 11th ed)

Also Known As:

Networked: 1206 relevant articles (49 outcomes, 146 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hemingway, Janet: 13 articles (07/2015 - 12/2003)
2.	Ranson, Hilary: 11 articles (01/2014 - 12/2003)
3.	Eskenazi, Brenda: 10 articles (12/2015 - 11/2004)
4.	Longnecker, Matthew P: 9 articles (12/2014 - 02/2007)
5.	Bornman, Riana: 8 articles (12/2015 - 08/2010)
6.	Bouwman, Hindrik: 7 articles (10/2015 - 06/2011)
7.	Cohn, Barbara A: 7 articles (08/2015 - 10/2007)
8.	Grimalt, Joan O: 6 articles (01/2015 - 11/2008)
9.	Bradman, Asa: 5 articles (12/2015 - 04/2006)
10.	Cirillo, Piera M: 5 articles (08/2015 - 10/2007)

Related Diseases

1.	Malaria 01/01/2011 - "It needs to be determined if indoor residual spraying (IRS with DDT) will provide significant marginal protection against malaria over current best practice of long-lasting insecticidal nets (LLINs) and prompt treatment in a controlled trial, given that DDT is currently the most persistent insecticide for IRS. " 07/14/2001 - "DDT (1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane) is highly effective against most malaria-transmitting mosquitoes and is being widely used in malaria-endemic areas. " 12/01/2000 - "Despite the development of resistance to DDT in some populations of malaria vector Anopheles mosquitoes (Diptera: Culicidae), DDT remains generally effective when used for house-spraying against most species of Anopheles, due to excitorepellency as well as insecticidal effects. " 01/01/1953 - "The DDT house-spraying programme carried out throughout Greece between 1946 and 1950 proved highly effective against both the local malaria-vectors (Anopheles sacharovi and A. " 10/01/2005 - "Anopheles minimus, an important malaria vector of South East Asia, has reappeared in the Singhbum hills, East-Central India where deforestation and DDT residual spraying had reportedly eliminated it during the Malaria Eradication Programme. "
2.	Neoplasms (Cancer) 06/01/2013 - "The present study examined concentrations of DDT and TCS that decrease lytic function for alteration of NK binding to tumor targets. " 10/15/2005 - "Several studies have evaluated cancer risk associated with occupational and environmental exposure to dichlorodiphenyltrichloroethane (DDT). " 06/01/2005 - "However, both total HCH and total DDT were higher in the tumor tissues of the controls than in those of the study group; gamma-HCH was significantly different (P<0.05). " 03/01/2002 - "The most recent studies have ruled out the hypothesis of DDT derivatives as responsible for excess risks of cancer of the reproductive organs. " 07/01/1998 - "This ecologic study does not provide support to the hypothesis of a link between environmental exposure to DDT derivatives and cancer of the male reproductive tract."
3.	Visceral Leishmaniasis (Kala Azar) 03/01/1999 - "Spraying of DDT helped control kala-azar; however, there are reports of the vector Phlebotomus argentipes developing resistance. " 01/01/1994 - "Data on the operational efficacy of DDT indoor residual spraying against Phlebotomus argentipes, the vector of kala-azar in India, are scarce. " 11/01/2007 - "We undertook this study with a new approach of kala-azar elimination in this village with priority to treatment of cases followed by supplementation with supervised DDT spray for vector control. " 01/01/1994 - "We therefore undertook a study of the impact on kala-azar and its vector of DDT indoor residual spraying in the Varanasi district of eastern Uttar Pradesh. " 07/14/2015 - "DDT-based indoor residual spraying suboptimal for visceral leishmaniasis elimination in India."
4.	Seizures (Seizure) 01/01/1994 - "High dose p,p'-DDT (1000 but not 500 mg/kg), which also induced convulsions, only slightly increased 5-HT1 (unsubtyped) binding sites in cortex but not in brainstem or spinal cord and had no effect on antagonist-labelled 5-HT2 sites. " 08/01/1970 - "Effects of acute and chronic exposure to DDT and of DDT-drug interactions on experimental seizure responses." 03/01/1970 - "Effects of DDT and of drug-DDT interactions on electroshock seizures in the rat." 07/01/1968 - "Effects of acute and chronic exposure to DDT and of DDT-drug interactions on experimental seizure responses." 03/01/1981 - "These changes were maximal 5 h after treatment with pp'DDT, when the animals developed 'severe' convulsions. "
5.	Dengue (Dengue Fever) 11/07/1998 - "We analyzed 57 patients, 30 with imported dengue (ID) and 27 with dengue fever suffered during the trip (DDT). " 05/01/1994 - "Biochemical basis of DDT-resistance in Aedes aegypti population from a dengue affected area in Shahjahanpur city." 01/01/2015 - "Current results strongly advocate that DDT is no longer effective against dengue vectors, while thorough monitoring of malathion susceptibility in geographical area at dengue risk is inexorable to ascertain whether or not the resistance to malathion is focal. " 05/01/1994 - "Entomological studies conducted in Jalalnagar, Shahjahanpur city, Uttar Pradesh, India, during an outbreak of dengue in 1992, showed that Ae. aegypti mosquitoes were resistant to DDT and had some tolerance to malathion in the adults and the larvae. " 03/01/2011 - "The Epsilon glutathione transferase (GST) class in the dengue vector Aedes aegypti consists of eight sequentially arranged genes spanning 53,645 bp on super contig 1.291, which maps to chromosome 2. One Epsilon GST, GSTE2, has previously been implicated in conferring resistance to DDT. "

Related Drugs and Biologics

1.	Mephobarbital (Methylphenobarbital)
2.	Insecticides
3.	Malathion (Karbofos)
4.	cyhalothrin (Matador)
5.	Phenobarbital (Luminal)
6.	Sodium
7.	diphenyl (biphenyl)
8.	Chloroquine (Aralen)
9.	9,10-Dimethyl-1,2-benzanthracene (DMBA)
10.	Aerosols

Related Therapies and Procedures

1.	Angioplasty (Angioplasty, Transluminal)
2.	Insecticide-Treated Bednets
3.	Intravenous Injections
4.	Mosquito Nets
5.	Chemoprevention