Dapsone

A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)

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Networked: 2368 relevant articles (255 outcomes, 250 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Zhang, Furen: 10 articles (02/2022 - 05/2017)
2.	Liu, Hong: 9 articles (02/2022 - 05/2017)
3.	Ríos, Camilo: 9 articles (01/2019 - 03/2004)
4.	Kast, Richard E: 8 articles (05/2022 - 10/2011)
5.	Dehpour, Ahmad Reza: 8 articles (05/2022 - 12/2019)
6.	Kircik, Leon: 8 articles (04/2021 - 07/2011)
7.	Zillikens, Detlef: 7 articles (11/2021 - 05/2002)
8.	Diaz-Ruiz, Araceli: 7 articles (10/2021 - 11/2008)
9.	Tanghetti, Emil: 7 articles (11/2018 - 07/2011)
10.	Matsuoka, Masanori: 7 articles (06/2017 - 09/2003)

Related Diseases

1.	Acne Vulgaris 08/01/2016 - "The most frequently reported increase in severity for all of the dermal tolerability scales was from "none" to "mild."<BR /> Dapsone gel, 7.5% applied topically once daily is an effective, safe, and well-tolerated treatment for acne vulgaris. " 09/01/2018 - "Therefore, oral dapsone was administered as an alternative treatment, and we reached a complete remission of acne lesions within six months. " 02/01/2022 - "Dapsone gel is effective in treating acne, and there is no significant difference in adverse events compared with other drugs." 02/01/2016 - "Monotherapy with dapsone gel, 5% administered twice daily was safe and effective for treatment of facial acne in women with SOC. Significant improvement in overall acne severity and both inflammatory lesions and comedones was observed. " 02/01/2016 - "Dapsone gel, 5% monotherapy was associated with significant improvement in subject-assessed acne signs (P<.001) and impact on quality of life (QOL; P<.001), based on ASIS. "
2.	Leprosy (Hansen's Disease) 01/01/2016 - "Overall, the result from our analysis suggested that CID21480113 (4-(2-fluorophenylsulfonyl)benzenamine) could be developed into a promising lead compound and could be effective in treating dapsone resistant leprosy cases." 06/01/2009 - "leprae threatened leprosy control programmes, and increased the relapse rate of patients cured with dapsone monotherapy. " 03/01/2002 - "Serial antibody levels were measured in 666 leprosy patients after being cured with dapsone monotherapy. " 12/01/1999 - "Based upon the data from the Chinese National System for Leprosy Surveillance, this paper reports on the relapses in 297,343 leprosy patients [multibacillary (MB) 106,518, paucibacillary (PB) 190,825] cured by dapsone monotherapy. " 01/01/1997 - "Dapsone is a drug which is administered orally, on a daily basis, for four to five years as a cure for leprosy. "
3.	Infections 08/01/1993 - "Dapsone is well-tolerated in children and appears to be as effective in preventing PCP in children with human immunodeficiency virus infection as it is in adults." 03/01/2016 - "This study assessed the in vitro activity of dapsone versus Gram-positive and Gram-negative bacterial pathogens obtained from patients with infections. " 01/01/2016 - "The study was carried out on 120 CBA line-mice infected with M.leprae (VIII passage) from patient M; Dapsone and PYaTdl compound were administered to animals next day after the infection with forage at a dose of 25 mg/kg for 4.5, 6, 9 and 11 months. " 04/01/1989 - "However, treatment with dapsone (DDS) in the last 12 weeks of infection resulted in an initial enhancement of the humoral responses followed by a gradual decrease, though they were still significantly high at the end of the study." 09/01/1985 - "Studies were undertaken in three independent centers to compare the newer, in vitro radiometric macrophage (M phi) assay with the conventional mouse foot pad infection for the diagnosis of dapsone resistance. "
4.	Pneumocystis Pneumonia (Pneumocystis carinii Pneumonia) 05/01/1999 - "Toxicity and efficacy of daily vs. weekly dapsone for prevention of Pneumocystis carinii pneumonia in children infected with human immunodeficiency virus. " 01/01/2000 - "Were considered as eligible: randomized clinical trials, conducted in adults, with one arm evaluating dapsone as prophylactic agent for Pneumocystis Carinii Pneumonia (PCP). " 01/01/1991 - "In a prospective, noncomparative study, seven patients with mild Pneumocystis carinii pneumonia, characterized by room air arterial PO2 greater than 60 mm Hg at the time of presentation, were treated with dapsone alone at a dose of 200 mg daily. " 01/01/2020 - "Dapsone for Pneumocystis jirovecii pneumonia prophylaxis - applying theory to clinical practice with a focus on drug interactions." 01/01/2015 - "Dapsone is a commonly used second line drug for prophylaxis of pneumocystis jirovecii pneumonia (PJP) in immunocompromised patients. "
5.	Hemolytic Anemia 01/01/1988 - "The hemolytic anemia which frequently accompanies treatment of individuals with dapsone and other arylamine drugs is believed to be caused not by the parent drugs per se, but rather by metabolites which are formed during the clearance of the drugs in vivo. " 04/01/1979 - "Studies on dapsone induced haemolytic anaemia. " 10/06/2023 - "Dapsone-induced Heinz-body haemolytic anaemia." 05/01/2022 - "Dapsone-Associated Hemolytic Anemia in Renal Transplant Recipients With Normal Glucose-6-Phosphate-Dehydrogenase Levels." 01/01/2020 - "Hemolytic anemia associated with dapsone PCP prophylaxis in GBM patients with normal G6PD activity."

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3.	Adrenal Cortex Hormones (Corticosteroids)
4.	Clofazimine (Lamprene)
5.	Colchicine
6.	Pentamidine (NebuPent)
7.	Primaquine
8.	Sulfones
9.	Trimethoprim (Proloprim)
10.	Prednisolone (Predate)

Related Therapies and Procedures

1.	Therapeutics
2.	Gluten-Free Diet
3.	Injections
4.	Renal Dialysis (Hemodialysis)
5.	Drug Therapy (Chemotherapy)