Dantrolene (Dantrium)

Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.

Also Known As:

Networked: 666 relevant articles (74 outcomes, 53 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Parness, Jerome: 5 articles (06/2012 - 09/2002)
2.	Ikemoto, Noriaki: 5 articles (08/2011 - 09/2002)
3.	Rosenberg, Henry: 4 articles (09/2015 - 12/2003)
4.	Wappler, Frank: 4 articles (01/2013 - 11/2003)
5.	Kobayashi, Shigeki: 4 articles (08/2011 - 06/2005)
6.	Yamamoto, Takeshi: 4 articles (08/2011 - 09/2002)
7.	Nasledov, G A: 4 articles (02/2007 - 03/2004)
8.	Katina, I E: 4 articles (02/2007 - 03/2004)
9.	Wappler, F: 3 articles (07/2015 - 03/2003)
10.	Wei, Huafeng: 3 articles (01/2015 - 12/2010)

Related Diseases

1.	Malignant Hyperthermia 12/01/2005 - "Dantrolene is the only drug proven effective for prevention and treatment of malignant hyperthermia (MH). " 01/01/1980 - "Dantrolene, a skeletal muscle relaxant, has been proven prophylactic and therapeutic for malignant hyperthermia (MH) in swine. " 03/01/2008 - "Dantrolene sodium, the only drug effective for treatment of malignant hyperthermia, has low water solubility that makes its clinical use difficult. " 03/01/2001 - "Dantrolene is the only known effective treatment for malignant hyperthermia. " 10/01/1998 - "Dantrolene is the only known effective treatment for malignant hyperthermia. "
2.	Fever (Fevers) 06/01/1997 - "We report two cases of hyperthermia after cardiac surgery in whom dantrolene was very effective in reducing the high rectal temperature." 08/01/1992 - "This abnormally high fever was relieved only by dantrolene sodium. " 10/01/2014 - "We could not eliminate the possibility of central hyperthermia as a cause of hyperthermia in the present patient If marked postoperative hyperthermia must be addressed immediately and managed appropriately in neurosurgical patients and dantrolene having few serious side effects, we were able to control his symptoms immediately after the infusion of dantrolene. " 06/01/2014 - "Although the delivery of supportive care and the administration of dantrolene are the core principles in the management of MH, perioperative fever does not always mean a MH in patients at risk for MH, and other common causes of fever should also be considered. " 01/01/2012 - "Treatment with dantrolene may be indicated in patients with continued hyperthermia despite aggressive traditional treatment."
3.	Neuroleptic Malignant Syndrome 03/01/2014 - "On suspicion of neuroleptic malignant syndrome(NMS) onset, dantrolene sodium hydrate was administered, resulting in marked improvement of the symptoms. " 02/01/2010 - "She received infusion of 140 mg dantrolene in total under suspicion of having neuroleptic malignant syndrome, but her symptoms improved slightly. " 05/01/1998 - "Efficacy of prolonged large-dose dantrolene for severe neuroleptic malignant syndrome." 01/01/2012 - "Under a diagnosis of neuroleptic malignant syndrome, dantrolene was administered. " 09/01/2003 - "Neuroleptic malignant syndrome following cardiac surgery: successful treatment with dantrolene."
4.	Contracture 09/01/1989 - "This study showed that dantrolene sodium is useful in the treatment of traumatic contracture, and that it does not alter an individual's overall performance. " 09/01/1989 - "Dantrolene sodium in traumatic muscle contracture: double-blind clinical and pharmacological trial." 09/15/2003 - "Following the introduction of efficient diagnostic and therapeutic tools--the in vitro contracture test and intravenous treatment with dantrolene--a dramatic decline in mortality rates has been observed. " 08/01/1999 - "On dantrolene treatment, the patient became asymptomatic, and the ischemic test was performed without contracture. " 11/01/1997 - "Pretreatment with dantrolene significantly delayed the start of contracture development in MHS muscles, whereas in MHN muscles no contractures were observed after dantrolene. "
5.	Seizures (Seizure) 08/01/2006 - "dSP and dantrolene did not modify seizure suppression through GalR1 and GalR2, but eliminated the proconvulsant effect of PTX + galanin(1-29) and PTX + galanin(2-11) combinations. " 08/01/2006 - "Dantrolene showed no anticonvulsant action against either the stages of seizures or afterdischarge durations in fully kindled rats. " 08/01/2006 - "To investigate the effects of dantrolene on seizures in already kindled rats, we determined generalized seizure threshold (GST) that is the minimum electric current necessary to evoke generalized seizures in fully kindled rats. " 08/01/2004 - "Thus, 67% of rats (four out of six) treated with toxin and dantrolene had electrographic convulsions, but only for 30 min after injection and none of them presented neuronal damage. " 04/01/1995 - "The results emphasize the importance of Dantrolene-sensitive Ca2+ release from intracellular stores for the development of seizure-induced neuronal death."

Related Drugs and Biologics

1.	Bromocriptine (Parlodel)
2.	Dantrolene (Dantrium)
3.	Diazepam (Valium)
4.	Sodium
5.	Diltiazem (Cardizem)
6.	Haloperidol (Haldol)
7.	Halothane (Fluothane)
8.	Nimodipine (Modus)
9.	Benzodiazepines
10.	azumolene

Related Therapies and Procedures

1.	Intravenous Injections
2.	Oral Administration
3.	Liver Transplantation
4.	Homologous Transplantation (Allograft)
5.	Ambulatory Surgical Procedures (Outpatient Surgery)