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D-Amino-Acid Oxidase (D-Amino Acid Dehydrogenase)

Subscribe to New Research on D-Amino-Acid Oxidase

Also Known As:

D-Amino Acid Dehydrogenase; Acid Dehydrogenase, D-Amino; Acid Oxidase, dextro-Amino; D Amino Acid Dehydrogenase; D Amino Acid Oxidase; Dehydrogenase, D-Amino Acid; Oxidase, D-Amino-Acid; Oxidase, dextro-Amino Acid; dextro Amino Acid Oxidase; dextro-Amino Acid Oxidase; D-Amino-acid:oxygen oxidoreductase (deaminating)

Networked: 141 relevant articles (3 outcomes, 22 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Oxidoreductases: 9264
    - Oxidoreductases Acting on CH-NH2 Group Donors
      - Amino Acid Oxidoreductases
        D-Amino-Acid Oxidase: 141
        D-lysopine dehydrogenase
        human DAO protein
        mouse Dao1 protein
        N(6)-(6-carbamoylhexyl)-FAD-D-amino acid oxidase

Experts

1.	Pollegioni, Loredano: 12 articles (12/2015 - 03/2006)
2.	Sacchi, Silvia: 10 articles (12/2015 - 03/2006)
3.	Molla, Gianluca: 10 articles (03/2013 - 03/2006)
4.	Wang, Yong-Xiang: 9 articles (12/2015 - 06/2008)
5.	Fukui, Kiyoshi: 6 articles (12/2015 - 04/2006)
6.	Hashimoto, Kenji: 6 articles (06/2015 - 06/2005)
7.	Gong, Nian: 5 articles (12/2015 - 01/2011)
8.	Rietschel, Marcella: 5 articles (06/2015 - 11/2005)
9.	Nöthen, Markus M: 5 articles (06/2015 - 11/2005)
10.	Fang, Jun: 5 articles (06/2012 - 06/2002)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 12/01/2013 - "The preliminary results show promise for d-amino acid oxidase inhibition as a novel approach for new drug development for schizophrenia." 01/01/2013 - "Structural, phylogenetic and docking studies of D-amino acid oxidase activator (DAOA), a candidate schizophrenia gene." 04/01/2010 - "Association study of 20 genetic variants at the (D)-amino acid oxidase gene in schizophrenia." 10/01/2009 - "Potential pathophysiological role of D-amino acid oxidase in schizophrenia: immunohistochemical and in situ hybridization study of the expression in human and rat brain." 10/16/2007 - "A series of genetic studies have identified the D-amino acid oxidase (DAO) gene as potentially contributing to schizophrenia susceptibility. "
2.	Neurobehavioral Manifestations 01/01/2013 - "Cellular concentrations of D-serine are regulated by synthesis due to the enzyme serine racemase (isomerization reaction) and by degradation due to the same enzyme(elimination reaction) as well as by the FAD-containing flavoenzyme D-amino acid oxidase (DAAO, oxidative deamination reaction).Several findings have linked low levels of D-serine to schizophrenia: D-serine concentrations in serum and cerebrospinal fluid have been reported to be decreased in schizophrenia patients while human DAAO activity and expression are increased; oral administration of D-serine improved positive, negative, and cognitive symptoms of schizophrenia as add-on therapy to typical and atypical antipsychotics.This"
3.	Bipolar Disorder (Mania) 10/05/2009 - "The D-amino acid oxidase activator (DAOA, previously known as G72) gene, mapped on 13q33, has been reported to be genetically associated with bipolar disorder (BP) in several populations. " 06/01/2009 - "The G72/G30 (D-amino-acid oxidase activator) complex was the first gene to be associated with bipolar disorder (BPD) in European populations, but until now no such association has been identified in Asian populations. " 01/01/2008 - "The G72/G30 gene complex (G72 also known as D-amino acid oxidase activator, DAOA) and its chromosomal region 13q32-34 have been linked and associated with both schizophrenia (SCZ) and bipolar disorder (BP) in multiple studies, including our initial association report on BP. However, the inconsistency of associated variants across studies is obvious. " 06/01/2015 - "DAOA, D-amino acid oxidase activator) is a susceptibility gene for both schizophrenia and bipolar disorder. " 01/01/2011 - "The D-amino acid oxidase activator gene (G72) has been found associated with several psychiatric disorders such as schizophrenia, major depression, and bipolar disorder. "
4.	Ischemia 01/01/2012 - "Study on the decrease of renal D-amino acid oxidase activity in the rat after renal ischemia by chiral ligand exchange capillary electrophoresis." 11/01/2004 - "Application of D-amino acid oxidase, an enzyme that degrades D-serine, markedly inhibited neuronal damage by NMDA and simulated ischemia, which was reversed by addition of excess D-serine or glycine. "
5.	Genetic Predisposition to Disease (Genetic Predisposition) 01/01/2009 - "Previous linkage and association studies have implicated the D-amino acid oxidase activator gene (DAOA)/G30 locus or neighbouring region of chromosome 13q33.2 in the genetic susceptibility to both schizophrenia and bipolar disorder. "

Related Drugs and Biologics

1.	Antipsychotic Agents (Antipsychotics)
2.	Serine (L-Serine)
3.	serine racemase
4.	Sodium Benzoate
5.	Flavin-Adenine Dinucleotide (FAD)
6.	N-Methylaspartate (NMDA)
7.	Neuregulin-1 (Neuregulin 1)
8.	Carrier Proteins (Binding Protein)
9.	dystrobrevin
10.	Benzoates (Benzoate)

Related Therapies and Procedures

1.	Oral Administration
2.	Enzyme Therapy
3.	Therapeutics
4.	Electrodes (Electrode)
5.	Analgesia