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Cytochrome P-450 Enzyme System (Cytochrome P450)

A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.
Also Known As:
Cytochrome P450; Cytochrome P 450; Cytochrome P-450; CYP450 Family; CYP450 Superfamily; Cytochrome P-450 Enzymes; Cytochrome P-450 Families; Cytochrome P-450 Monooxygenase; Cytochrome P-450 Oxygenase; Cytochrome P-450 Superfamily; Cytochrome P450 Superfamily; Cytochrome p450 Families; P-450 Enzymes; P450 Enzymes; Cytochrome P 450 Dependent Monooxygenase; Cytochrome P 450 Enzyme; Cytochrome P 450 Enzyme System; Cytochrome P 450 Enzymes; Cytochrome P 450 Families; Cytochrome P 450 Monooxygenase; Cytochrome P 450 Oxygenase; Cytochrome P 450 Superfamily; Enzyme, Cytochrome P-450; Enzyme, P-450; Enzyme, P450; Enzymes, Cytochrome P-450; Enzymes, P-450; Enzymes, P450; Monooxygenase, Cytochrome P-450; Monooxygenase, Cytochrome P-450-Dependent; P 450 Enzyme; P 450 Enzymes; P-450 Enzyme, Cytochrome; P-450 Enzymes, Cytochrome; Superfamily, CYP450; Superfamily, Cytochrome P-450; Superfamily, Cytochrome P450; Cytochrome P-450 Enzyme; Cytochrome P-450-Dependent Monooxygenase; P-450 Enzyme; P450 Enzyme
Networked: 5365 relevant articles (135 outcomes, 627 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Falck, John R: 44 articles (10/2021 - 07/2004)
2. Zeldin, Darryl C: 40 articles (05/2020 - 03/2003)
3. El-Kadi, Ayman O S: 34 articles (01/2022 - 04/2004)
4. Gonzalez, Frank J: 24 articles (05/2022 - 09/2002)
5. Hammock, Bruce D: 24 articles (04/2021 - 12/2003)
6. Malik, Kafait U: 24 articles (01/2021 - 02/2002)
7. Moorthy, Bhagavatula: 21 articles (02/2021 - 01/2003)
8. Edin, Matthew L: 21 articles (01/2019 - 07/2007)
9. Ingelman-Sundberg, Magnus: 19 articles (01/2021 - 09/2003)
10. Morgan, Edward T: 18 articles (01/2022 - 12/2002)

Related Diseases

1. Neoplasms (Cancer)
2. Inflammation (Inflammations)
3. Body Weight (Weight, Body)
4. Carcinogenesis
5. Lung Injury

Related Drugs and Biologics

1. Enzymes
2. Proteins (Proteins, Gene)
3. Cytochrome P-450 CYP3A
4. Isoenzymes
5. Acids
6. Antioxidants
7. Cytochrome P-450 CYP1A1 (CYP1A1)
8. Protein Isoforms (Isoforms)
9. Omeprazole (Prilosec)
10. Cytochrome P-450 CYP2C19

Related Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Percutaneous Coronary Intervention
4. Castration
5. Resuscitation