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Cytidine Monophosphate N-Acetylneuraminic Acid

A nucleoside monophosphate sugar which donates N-acetylneuraminic acid to the terminal sugar of a ganglioside or glycoprotein.
Also Known As:
CMP-Sialic Acid; Cytidine Monophosphate N Acetylneuraminic Acid; Acetylneuraminic Acid, CMP; CMP N Acetylneuraminic Acid; CMP Sialic Acid; CMP Acetylneuraminic Acid; CMP-N-Acetylneuraminic Acid; CMP-NANA; D-glycero-beta-D-galacto-2-Nonulopyranosonic acid, 5-(acetylamino)-3,5-dideoxy-, 2-(hydrogen 5'-cytidylate)
Networked: 38 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Lefeber, Dirk J: 2 articles (12/2015 - 08/2013)
2. Morava, Eva: 2 articles (12/2015 - 08/2013)
3. Wevers, Ron A: 2 articles (12/2015 - 08/2013)
4. Gerardy-Schahn, Rita: 2 articles (08/2013 - 09/2005)
5. Bork, Kaya: 2 articles (09/2007 - 09/2005)
6. Horstkorte, Rüdiger: 2 articles (09/2007 - 09/2005)
7. Reutter, Werner: 2 articles (09/2007 - 09/2005)
8. Boons, Geert-Jan: 1 article (01/2021)
9. Kobayashi, Tasuku: 1 article (01/2021)
10. Nakamura, Chihiro: 1 article (01/2021)

Related Diseases

1. Infections
2. Neoplasms (Cancer)
05/01/1977 - "In the fast-growing hepatomas 3924A and 9121, levels up to 21.5 nmoles/g, wet weight, were found, However, the content of CMP-N-acetylneuraminic acid in hepatomas was indluenced to a lesser extent by the degree of differentiation of the tumor. "
10/15/1995 - "However, a sialyltransferase activity (CMP-sialic acid Gal beta 1-3GalNAc alpha 3-sialyltransferase) was increased several fold in all three cancer cell lines. "
11/01/1990 - "Kinetic studies revealed that the Km values toward asialofetuin at a saturation concentrations of CMP-N-acetylneuraminic acid for both liver and hepatoma enzymes are very closed, while V value was lower for the tumor enzyme. "
12/01/1994 - "UDP-GlcNAc: Gal beta 1-3GalNAc beta 6-N-acetylglucosaminyltransferase was also decreased in cancer concomitant with a loss of the ability to synthesize the I antigen and core 4, GlcNAc beta 1-6(GlcNAc beta 1-3) GalNAc-, CMP-sialic acid: Gal beta 1-3GalNAc-R alpha 3-sialyltransferase and GDP-fucose: Gal beta-R alpha 2-fucosyltransferase, synthesizing the blood group H determinant, were found to be 4- and 3- to 8-fold increased, respectively, in cancer compared to normal tissue. "
01/01/1985 - "Sialyltransferase (CMP-sialic acid:asialofetuin sialyltransferase) and human mammary epithelial antigens (HME-Ags, cell surface antigens specific to human mammary epithelial cells) were determined in plasma of nude mice grafted with breast and non-breast human tumors to assess their possible usefulness as breast cancer markers. "
3. Hepatocellular Carcinoma (Hepatoma)
4. Sialic Acid Storage Disease (Salla Disease)
5. Colorectal Neoplasms (Colorectal Cancer)

Related Drugs and Biologics

1. Sialyltransferases
2. Lipopolysaccharides
3. Lactic Acid (Lactate)
4. Nitrite Reductases (Nitrite Reductase)
5. Lipoproteins (Lipoprotein)
6. Heme (Haem)
7. Electron Transport Complex IV (Cytochrome c Oxidase)
8. N-Acetylneuraminic Acid (Sialic Acid)
9. Enzymes
10. asialofetuin