Cysticercosis

Infection with CYSTICERCUS, the larval form of the various tapeworms of the genus Taenia (usually T. solium in man). In humans they penetrate the intestinal wall and invade subcutaneous tissue, brain, eye, muscle, heart, liver, lung, and peritoneum. Brain involvement results in NEUROCYSTICERCOSIS.

Also Known As:

Networked: 787 relevant articles (61 outcomes, 77 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Infection
2.	Schistosomiasis (Bilharziasis)
3.	Neurocysticercosis
4.	Echinococcosis (Hydatid Cysts)
5.	Parasitic Diseases (Parasitic Disease)

Experts

1.	Gilman, Robert H: 24 articles (12/2015 - 08/2002)
2.	Gonzalez, Armando E: 23 articles (12/2015 - 10/2003)
3.	Tsang, Victor C W: 22 articles (04/2015 - 08/2002)
4.	Garcia, Hector H: 21 articles (12/2015 - 10/2003)
5.	Ito, Akira: 17 articles (04/2014 - 06/2003)
6.	Cysticercosis Working Group in Peru: 14 articles (12/2015 - 07/2001)
7.	Sciutto, Edda: 14 articles (12/2013 - 07/2002)
8.	Fragoso, Gladis: 14 articles (12/2013 - 07/2002)
9.	Dorny, Pierre: 13 articles (12/2015 - 05/2002)
10.	Sako, Yasuhito: 13 articles (04/2014 - 06/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cysticercosis:

1.	AntigensIBA 05/01/2013 - "We recently showed that an antigen (TSOL16), expressed in Escherichia coli, confers high levels of protection against Taenia solium cysticercosis in pigs, which provides a strategy for control of T. " 02/01/2008 - "Effective production and purification of the glycosylated TSOL18 antigen, which is protective against pig cysticercosis." 02/09/2007 - "Several antigen preparations induce protection against porcine cysticercosis in experimental settings but only one subunit vaccine (S3Pvac) has been tested and proved effective in the field against naturally acquired disease. " 05/01/1999 - "The Taenia crassiceps recombinant antigen KETc7 has been shown to be effective as a vaccine against experimental murine cysticercosis, a laboratory model used to test potentially promising molecules against porcine Taenia solium cysticercosis. " 08/01/2013 - "Our work of the last 25 yr was concerned with the development of a vaccine aimed to prevent porcine Taenia solium cysticercosis and was based on cross-reacting Taenia crassiceps antigens that had proved protective against experimental intraperitoneal murine T. "
2.	Praziquantel (Biltricide)FDA Link 06/01/1984 - "Computer tomography is a valuable adjunct to the diagnosis and follow up of cerebral cysticercosis and praziquantel was found to be very effective in the treatment of the parasitoses." 01/01/1991 - "We experienced a case of pulmonary cysticercosis confirmed at Gyeongsang National University Hospital by means of an open lung biopsy and treated successfully with praziquantel (50 mg/kg per day for 15 days). " 11/01/2000 - "This single-dose regimen of praziquantel seems to be effective for therapy of subarachnoid cysticercosis. " 08/01/1991 - "In order to evaluate therapeutic efficacy of praziquantel against cysticercosis in pigs caused by the 'Taiwan Taenia' 16 small-ear miniature pigs were each fed with 10,000 or 30,000 eggs. " 01/01/1989 - "Clinical evaluation of the therapeutic efficacy of praziquantel against human cysticercosis."
3.	Albendazole (Albenza)FDA Link 05/01/1981 - "[Preventive and curative efficacy of a albendazole in hepatico-peritoneal cysticercosis in rabbit. " 12/01/2001 - "However, albendazole is possibly more effective in subarachnoidal, ventricular and spinal forms of cysticercosis, and frequently obviates the need for surgery. " 02/14/2006 - "Albendazole trial at 15 or 30 mg/kg/day for subarachnoid and intraventricular cysticercosis." 11/01/1995 - "The present study demonstrates the effectiveness in clinical and radiological terms of albendazole 800 mg/day for 8 days for the majority of patients affected with cystic or encephalitic parenchymatous cysticercosis. " 11/01/1995 - "In a randomized, double-blind, placebo controlled study, we allocated 29 consecutive patients (22 men and 7 women) with multiple cystic lesions on computed tomography (CT) of the head suggestive of cysticercosis to 7 days treatment with albendazole (15 mg/kg/day) or placebo. "
4.	AntibodiesIBA 04/01/2012 - "Cross-reactions with antibodies in sera of patients with other parasitic affections (fasciolosis, schistosomosis, amebosis, cysticercosis, and filarioses) did occur at variable frequencies, but could be eliminated through the use of confirmatory testing. " 09/30/1999 - "Therefore, the presence of passively transferred antibodies must be considered in studies that examine the prevalence of cysticercosis in pigs. " 04/01/2015 - "Serum samples from 981/985 individuals were processed for cysticercosis antibodies on immunoblot. " 09/01/2014 - "In both the intervention and control (753 residents) we measured incidence of exposure by sampling the pig population every 4 months for serum antibodies against cysticercosis using enzyme-linked immunoelectrotransfer blot. " 05/01/2014 - "The prevalence of porcine cysticercosis was estimated using tongue inspection, ultrasound and determination of antibodies, before and three years after the application in three regions of the state of Guerrero. "
5.	DNA (Deoxyribonucleic Acid)IBA 01/02/2007 - "Induction of protection against porcine cysticercosis in growing pigs by DNA vaccination." 08/01/2015 - "martis cysticercosis in a French immunocompetent patient, confirmed by DNA analyses of biopsy material. " 03/01/2013 - "Bovine cysticercosis was confirmed through examination of histological sections of muscle lesions and PCR using DNA extracted from cysticerci. " 04/01/2010 - "The DNA vaccine displays prominent advantages in the prevention on cysticercosis. " 06/01/2006 - "Overall, intrahepatic plasmid CpG-DNA immunization provokes an exacerbated nonspecific immune response that can effectively control Taenia crassiceps cysticercosis."
6.	oxfendazoleIBA 10/18/1997 - "Oxfendazole has been shown to be highly effective against porcine cysticercosis, when given as a single dose at 30 mg/kg bodyweight. " 01/01/2013 - "Oxfendazole has shown to be effective for the control of porcine cysticercosis; however, it needs to be integrated with other control approaches. " 01/01/2012 - "A randomized controlled field trial to evaluate the effectiveness of a single oral dose of 30 mg/kg of oxfendazole (OFZ) treatment for control of porcine cysticercosis was conducted in 4 rural villages of Angónia district, north-western Mozambique. " 10/18/1997 - "Treatment of porcine cysticercosis with oxfendazole: a dose-response trial." 11/01/2013 - "Three potential intervention scenarios for pigs are compared for control of cysticercosis, using either oxfendazole or vaccination. "
7.	VaccinesIBA 02/01/2009 - "These provide informative results for the development of effective 45W-4B vaccines against cysticercosis caused by both Chinese and Mexican T. " 06/01/2008 - "It is informative to guide using of recombinant 45W vaccines to control porcine cysticercosis caused by Asiatic or African/Latin American T. " 01/01/2008 - "This article reviews current knowledge on the development vaccines against porcine cysticercosis. " 01/01/2008 - "Vaccines against cysticercosis." 07/31/2006 - "There are many epidemiological studies that have been conducted mainly in Latin American countries that have evaluated intervention measures for control of cysticercosis including the development and testing of vaccines. "
8.	SteroidsIBA 01/01/2008 - "We review here the role that sex steroids play in experimental intraperitoneal Taenia crassiceps cysticercosis of male and female BalbC/AnN mice. " 09/01/2005 - "Sex steroids play a significant role in regulating the parasite load in experimental intraperitoneal Taenia crassiceps cysticercosis of male and female Balbc/anN mice. " 06/01/2005 - "The authors present a case of optic nerve cysticercosis in a 32-year-old patient who presented with sudden blurring of vision in the left eye and a transient visual improvement on systemic steroids. " 09/01/1996 - "The two patients not responding to steroids underwent surgical excision and histopathology confirmed the diagnosis of cysticercosis. " 06/01/1992 - "Thus, gonadal effect on mouse susceptibility to cysticercosis appears to be mediated via the immune system, and it is probably not the consequence of the major sex steroids acting directly upon the parasites. "
9.	Complementary DNA (cDNA)IBA 07/01/1998 - "Protection against murine cysticercosis using cDNA expression library immunization." 10/14/1999 - "cDNA expression library immunization (cDELI), based on the use of a large number of pathogen's cDNA clones, has been previously used in our laboratory in an experimental model of murine Taenia crassiceps cysticercosis. " 03/25/2003 - "Taenia solium cDNA sequence encoding a putative immunodiagnostic antigen for human cysticercosis." 12/01/1998 - "We describe the isolation and characterization of cDNA clones encoding 2 facilitated diffusion glucose transporters (TGTP1 and TGTP2) from Taenia solium, the causal agent of human and porcine cysticercosis. " 10/01/1994 - "A Taenia crassiceps cDNA sequence encoding a putative immunodiagnostic antigen for bovine cysticercosis."
10.	AnthelminticsIBA 10/01/1996 - "cysticercosis cured with drug management only, which supports the hypothesis that management with anthelmintics might be successfully used in this form of cysticercosis. " 01/01/2013 - "There is a need for standardised guidelines for evaluating the efficacy of anthelmintics against porcine cysticercosis, and more efficacy studies are needed since the conclusions so far are based on a limited number of studies using few infected pigs. " 01/01/2015 - "solium cysticercosis were gender (OR = 3.0; 95% CI = 1.7-5.4), increased age (OR = 2.3; 95% CI = 1.2-4.2), husbandry system (OR = 5.1; 95% CI = 2.4-11.2), feed type (OR = 16.9; 95% CI = 2.3-124.3), not using anthelmintics in pigs (OR = 11.9; 95% CI = 5.0-28.5), not using anthelmintics in owner (OR = 2.5; 95% CI = 1.4-4.4), no hand-washing before feeding (OR = 31.5; 95% CI = 4.3-230.9), and pork consumption of owner (OR = 37.4; 95% CI = 9.0-156.1) in the study area. " 01/01/2013 - "Efficacy and safety of anthelmintics tested against Taenia solium cysticercosis in pigs." 05/31/2008 - "The most common production practices identified in a questionnaire survey of sheep farmers that may increase the risk of exposure of sheep to hydatidosis, cysticercosis, and gid were the improper disposal of dead animals, the access of farm dogs to offal of slaughtered sheep, the carelessness of farmers to treat farm dogs with anthelmintics, and the grazing of flocks in fields where stray dogs have free access."

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 12/01/1983 - "Experimental chemotherapy of Taenia saginata cysticercosis - a field trial." 08/30/2002 - "Chemotherapy of infected pigs is a possible strategy for avoiding disease transmission and improving health programs in endemic areas of cysticercosis. " 09/01/2000 - "[Chemotherapy of cysticercosis. " 03/01/1997 - "[The chemotherapy of cysticercosis. " 10/01/1994 - "The management of cysticercosis has been radically changed by the advent of effective chemotherapy. "
2.	Aftercare (After-Treatment) 06/01/2014 - "[Comparative study on EEG and neuroimaging of patients with cerebral cysticercosis before and after treatment]." 01/01/1995 - "The results indicate that after the patients with cysticercosis had been treated for one, two and three treatment courses, the levels of CAg in sera decreased with the increase in the number of treatment courses, their average OD value dropped from 0.499 before treatment to 0.291, 0.073 and 0.051 after treatment, respectively, and the corresponding negative conversion rates of CAg detection were 20.0%, 57.9% and 87.5%, respectively. " 04/18/1991 - "Total recovery of visual function after treatment for cerebral cysticercosis." 01/01/1989 - "The efficacy of the treatment of cerebral cysticercosis was assessed by the frequency of convulsions before and after treatment, and by the disappearance or decreased densities of the cystic lesions at brain CT scanning (6 months follow up). " 09/03/1992 - "The course of seizures after treatment for cerebral cysticercosis."
3.	Immunotherapy 01/01/1997 - "Immunotherapy for porcine cysticercosis: implications for prevention of human disease. " 03/01/1983 - "[Immunotherapy in the symptomatology of cerebral cysticercosis]." 07/01/2015 - "Blood samples from10 anti-NMDAR encephalitis patients, 10 anti-NMDAR encephalitis patients whose physical conditions have improved after 3 months of immunotherapy, 20 virus (meningitis) encephalitis patients, 20 tuberculosis (meningitis) encephalitis patients, 10 purulent (meningitis) encephalitis patients, 20 cerebral cysticercosis patients, 20 ischemic stroke patients, 20 intracerebral hemorrhage patients, 15 neuromyelitis optica patients, 15 multiple sclerosis patients, 15 moyamoya disease patients, and 20 negative controls were collected for real-time quantitative PCR (qRT-PCR) analysis. " 01/01/1997 - "Previous research suggests that reinfection with cysticercosis or immunotherapy with cysticercal antigens may cause degeneration of cysticerci, potentially curing porcine cysticercosis. "
4.	Injections 04/05/2012 - "Taenia pisiformis experimental rabbit cysticercosis was used as a model to compare the efficacy of the oral vaccine vs. the injectable S3Pvac-synthetic and S3Pvac-phage versions. "
5.	Ventriculoperitoneal Shunt 04/01/2002 - "Among patients with vesicular stage cysticercosis, placement of a ventriculoperitoneal shunt followed by a course of antihelminthic medication seems to promote shunt longevity." 04/01/1995 - "Twenty-six patients with hydrocephalus secondary to chronic arachnoiditis due to meningeal cysticercosis were treated with a new ventriculoperitoneal shunt whose design is based on the rate of cerebrospinal fluid (CSF) production and shunt resistance rather than on ventricular pressure, which has been the principal parameter for most other shunting devices. " 04/01/1996 - "Effects of prednisone on ventriculoperitoneal shunt function in hydrocephalus secondary to cysticercosis: a preliminary study." 01/01/1989 - "Ten patients with cerebral cysticercosis seen between 1983 and 1986 were treated with praziquantel and in some cases by a ventriculoperitoneal shunt and/or surgical excision of cysts. "