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Cystathionine gamma-Lyase (Cysteine Desulfhydrase)

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A multifunctional pyridoxal phosphate enzyme. In the final step in the biosynthesis of cysteine it catalyzes the cleavage of cystathionine to yield cysteine, ammonia, and 2-ketobutyrate. EC 4.4.1.1.

Also Known As:

Cysteine Desulfhydrase; Cystine Desulfohydrolase; Cystathionine gamma Lyase; Deaminase, Homoserine; Dehydratase, Homoserine; Desulfhydrase, Cysteine; Desulfhydrase, Cystine; Desulfohydrolase, Cystine; gamma Cystathionase; gamma-Lyase, Cystathionine; Cystathionase; Cystine Desulfhydrase; Homoserine Deaminase; Homoserine Dehydratase; gamma-Cystathionase; L-Cystathionine cysteine-lyase (deaminating)

Networked: 84 relevant articles (0 outcomes, 14 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Lyases: 25
    - Carbon-Sulfur Lyases
      - Cystathionine gamma-Lyase: 84
        cystalysin: 6
        E coli MalY protein
        S cerevisiae CYS3 protein

Experts

1.	Bhatia, Madhav: 4 articles (02/2010 - 12/2004)
2.	Snyder, Solomon H: 3 articles (06/2010 - 10/2008)
3.	Tang, Chao-Shu: 3 articles (04/2010 - 02/2004)
4.	Tang, Chaoshu: 3 articles (07/2009 - 01/2004)
5.	Thiemermann, Christoph: 3 articles (03/2009 - 10/2005)
6.	Moore, Philip K: 3 articles (05/2008 - 12/2004)
7.	Yan, Hui: 3 articles (07/2004 - 01/2004)
8.	Seremak-Mrozikiewicz, Agnieszka: 2 articles (05/2015 - 02/2015)
9.	Bogacz, Anna: 2 articles (05/2015 - 02/2015)
10.	Bartkowiak-Wieczorek, Joanna: 2 articles (05/2015 - 02/2015)

Related Diseases

1.	Hypertension (High Blood Pressure) 07/16/2010 - "Disruption of gamma-cystathionase in mice leads to cardiovascular dysfunction and marked hypertension, suggesting a key role for this enzyme in H(2)S production in the vasculature. " 10/24/2008 - "H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase." 04/20/2008 - "Up to now, the reports on the relationship between the polymorphisms of cystathionine gamma-lyase gene (CTH) and essential hypertension (EH) are limited. " 04/20/2008 - "Relationship between cystathionine gamma-lyase gene polymorphism and essential hypertension in Northern Chinese Han population." 01/02/2004 - "This work showed that gene expression of cystathionine gamma-lyase (CSE), a H(2)S generating enzyme, and the activity of CSE in thoracic aorta were suppressed in hypertension rats. "
2.	Reperfusion Injury 06/15/2010 - "To study the protective function and pathophysiology of cystathionine gamma-lyase (CSE)/hydrogen sulfide (H(2)S) system in hepatic ischemia-reperfusion injury (HIRI) in rats. " 03/15/2009 - "Characterisation of cystathionine gamma-lyase/hydrogen sulphide pathway in ischaemia/reperfusion injury of the mouse kidney: an in vivo study." 03/15/2009 - "These findings suggest that hydrogen sulphide protects the kidney against ischaemia/reperfusion injury and that the increase in expression of the enzyme cystathionine gamma-lyase during ischaemia/reperfusion injury may be one of many endogenous mechanisms to limit renal ischaemia/reperfusion injury." 03/15/2009 - "Western blot analysis of the kidney taken at the end of the experiment demonstrated that cystathionine gamma-lyase, the enzyme responsible for generating hydrogen sulphide in the cardiovascular system, is expressed in the normal kidney and is significantly increased after ischaemia/reperfusion injury. " 10/01/2008 - "Generation of endogenous hydrogen sulfide by cystathionine gamma-lyase limits renal ischemia/reperfusion injury and dysfunction."
3.	Ischemia 07/01/2009 - "The activity of cystathionine-gamma-lyase, another enzyme responsible for endogenous H(2)S generation, was not significantly altered in the kidney upon ischemia-reperfusion. " 10/01/2009 - "Therefore, we designed the present study to investigate the roles of H2S in hepatic ischemia-reperfusion (HIR)-induced injury in rats by measuring H2S levels, H2S synthesizing activity, and cystathionine gamma-lyase (CSE) messenger RNA (mRNA) expression. " 10/01/2008 - "Administration of the irreversible cystathionine gamma-lyase (CSE) inhibitor, dL-propargylglycine, prevented the recovery of renal function after 45 min ischemia and 72 h reperfusion. " 06/06/2008 - "Lungs were subjected to 45 min ischemia followed by reperfusion (45 min) and were pretreated with H(2)S (50 micromol/l or 100 micromol/l) or an irreversible inhibitor of cystathionine-gamma-lyase (CSE), propargylglycine (PPG; 2 mmol/l). "
4.	Fibrosis (Cirrhosis) 01/01/2015 - "Our aim was to study the effect of caffeic acid phenethyl ester (CAPE) on iNOS and cystathionine gamma-lyase (CSE) of hepatic fibrosis rat, and discuss the anti-hepatic fibrosis mechanism of caffeic acid phenethyl ester. " 09/01/2005 - "L-Cysteine, a substrate of cystathionine-gamma-lyase (CSE), decreased vasoconstriction in normal rat livers (P < .05) but failed to do so in livers with cirrhosis. " 01/01/2015 - "Caffeic Acid Phenethyl Ester inhibit Hepatic Fibrosis by Nitric Oxide Synthase and Cystathionine Gamma-Lyase in Rats." 10/01/2013 - "To observe the level in plasma hydrogen sulfide (H2S) and the expression of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) (two key synthetases for endogenous H2S generation in the kidney) in obstructed kidney tissue among rats with tubulointerstitial fibrosis (TIF) induced by unilateral ureteral obstruction (UUO), and to explore the role of H2S in TIF. "
5.	Pulmonary Fibrosis (Hamman Rich Syndrome) 07/01/2009 - "The present study investigated the role of the endogenous cystathionine gamma-lyase (CSE) / hydrogen sulfide pathway in the pathogenesis of pulmonary fibrosis. " 04/01/2010 - "We previously reported that the endogenous cystathionine gamma-lyase (CSE)/hydrogen sulfide (H(2)S) pathway is implicated in the pathogenesis of bleomycin-induced pulmonary fibrosis in rats, but the exact cellular mechanisms are not well characterized. "

Related Drugs and Biologics

1.	Hydrogen Sulfide (Sulfide, Hydrogen)
2.	Cystathionine beta-Synthase (Serine Sulfhydrase)
3.	Hydrogen
4.	Enzymes
5.	Cystathionine
6.	Homocysteine
7.	Messenger RNA (mRNA)
8.	Methionine (L-Methionine)
9.	Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)
10.	5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase (Methyltetrahydrofolate Homocysteine Methyltransferase)

Related Therapies and Procedures

1.	Castration
2.	Thyroidectomy
3.	Peritoneal Dialysis
4.	Intraperitoneal Injections