Cystathionine

01/01/2018 - "This study aimed to identify mutations in the cystathionine β-synthase (CBS) gene which are associated with classical homocystinuria in nine Chinese patients. "
03/01/1974 - "Homocystinuria due to cystathionine synthase deficiency: enzymatic and ultrastructural studies."
03/28/2022 - "Classical homocystinuria (HCU) is an autosomal recessive inborn error of metabolism, which is caused by the cystathionine-β-synthase (CBS: encoded by CBS) deficiency. "
01/01/2021 - "One example would be a deficiency in cystathionine-β-synthase (CBS), which is seen in classical homocystinuria. "
05/01/2019 - "Classical homocystinuria is an autosomal recessive disorder caused by profound cystathionine β-synthase deficiency. "

12/29/1995 - "Cystathionine did not affect blood flow during ischemia-reperfusion. "
12/29/1995 - "We studied the protective effect of cystathionine on acute gastric mucosal injury induced by ischemia-reperfusion in rats. "
12/29/1995 - "Protective effect of cystathionine on acute gastric mucosal injury induced by ischemia-reperfusion in rats."
04/01/2013 - "Cystathionine γ-lyase protects against renal ischemia/reperfusion by modulating oxidative stress."
12/29/1995 - "These results indicate that the protective effect of cystathionine on acute gastric mucosal injury induced by ischemia-reperfusion may be due to the scavenging action against superoxide radicals in vivo."

01/01/2018 - "Elevated plasma cystathionine has been related to atherosclerosis, which is a major etiological factor for ischemic stroke. "
08/16/2023 - "Furthermore, the effect of H2S released from the coating on atherosclerosis-related signaling pathways such as CD31 and cystathionine γ-lyase (CSE), CD36, and ACAT-1 was investigated. "
03/01/2017 - "We previously reported that cystathionine γ-lyase knockout (CSE-KO) male mice develop atherosclerosis earlier than male wild-type (WT) mice. "
07/01/1977 - "Pyridoxine deficient monkeys failed to show any biochemical or pathological evidence of atherosclerosis, despite a significant decrease in the activity of hepatic cystathionine synthase."
01/01/2022 - "Atherosclerosis is associated with reduced vascular expression of the main endogenous H2S producing enzyme cystathionine-γ-lyase (CSE), and, hence, exogenous H2S administration could be beneficial in these patients, in particular after HS. "

01/01/2022 - "Previous studies have demonstrated that Cystathionine-β-synthase (CBS)/H2S system plays important roles in progression of various cancer. "
01/01/2022 - "The omission from the spectral analysis of cystathionine led to severe biases in the quantification of other neurochemicals that may play key roles in cancer metabolism."
01/01/2022 - "Cystathionine β-synthase (CBS) plays a crucial role in the occurrence of several types of malignancies. "
01/01/2022 - "Emerging roles of cystathionine β-synthase in various forms of cancer."
01/01/2020 - "Findings from our group have shown CO to mitigate drug resistance in certain cancer cells by the inhibition of cystathionine β-synthase (CBS), a key regulator of redox homeostasis in the cell. "

01/01/2022 - "Deficiencies in Cystathionine-β-synthase (CBS) lead to hyperhomocysteinemia (HHCy), which is considered a risk factor for cardiovascular, bone and neurological disease. "
02/01/2019 - "CVST due to hyperhomocysteinemia with cystathionine-β-synthase (CBS) gene mutation. "
11/01/2018 - "Although hyperhomocysteinemia (HHcy) occurs because of the deficiency in cystathionine-β-synthase (CBS) causing skeletal muscle dysfunction, it is still unclear whether this effect is mediated through oxidative stress, endoplasmic reticulum (ER) stress, or both. "
12/01/2017 - "Nitration-mediated deficiency of cystathionine β-synthase activity accelerates the progression of hyperhomocysteinemia."
09/01/2014 - "Alterations of retinal vasculature in cystathionine-β-synthase heterozygous mice: a model of mild to moderate hyperhomocysteinemia."