Cystathionine

03/01/1974 - "Homocystinuria due to cystathionine synthase deficiency: enzymatic and ultrastructural studies."
10/01/2015 - "Novel cystathionine β-synthase gene mutations in a Filipino patient with classic homocystinuria."
08/01/2015 - "Cystathionine-β-synthase (CBS) deficiency is the main cause of homocystinuria. "
03/01/2015 - "Classical homocystinuria is caused by mutations in the cystathionine β-synthase (CBS) gene. "
01/01/2015 - "The cystathionine β-synthase (CBS) gene has been shown to be related to homocystinuria. "

09/01/2010 - "This study aimed to examine the expression of cystathionine-γ-lyase(CSE)/H2S pathway in mice with viral myocarditis. "
09/01/2010 - "[Expression of cystathionine-γ-lyase/hydrogen sulfide pathway in CVB3-induced myocarditis in mice]."
12/01/2015 - "Panax Notoginseng Saponins Ameliorates Coxsackievirus B3-Induced Myocarditis by Activating the Cystathionine-γ-Lyase/Hydrogen Sulfide Pathway."
12/01/2015 - "This study is to determine the therapeutic effects of Panax notoginseng saponins (PNSs) on coxsackievirus B3 (CVB3)-induced myocarditis, and whether cystathionine-γ-lyase (CSE)/hydrogen sulfide (H2S) pathway is involved. "

01/01/2015 - "This is particularly evident in cancers of the colon and ovaries, where the malignant cells both overexpress cystathionine-β-synthase (CBS) and produce increased amounts of H2S, which enhances tumor growth and spread by (a) stimulating cellular bioenergetics, (b) activating proliferative, migratory, and invasive signaling pathways, and (c) enhancing tumor angiogenesis. "
01/01/1963 - "III. CYSTATHIONINE IN THE TUMOR TISSUE."
04/01/2014 - "Moreover, recent studies demonstrate that colorectal cancer cells up-regulate the H2 S-producing enzyme cystathionine β-synthase (CBS), and utilize its product, H2 S, as a metabolic fuel and tumour-cell survival factor; pharmacological CBS inhibition or genetic CBS silencing suppresses cancer cell bioenergetics and suppresses cell proliferation and cell chemotaxis. "
12/01/2014 - "Wnt/β-catenin signaling induces the transcription of cystathionine-γ-lyase, a stimulator of tumor in colon cancer."
07/23/2013 - "In contrast to CBS, silencing of cystathionine-γ-lyase (the expression of which was unchanged in colon cancer) did not affect tumor growth or bioenergetics. "

08/01/1989 - "in rats, it was eliminated from rat serum with a biological half-life of 1.19 +/- 0.23 hr. Subsequent to the decrease of serum cystathionine, the concentration of cyst(e)ine increased up to 14.5 +/- 1.2 mg/l, and then decreased with a half-life of 4.12 +/- 0.82 hr. The concomitant administration of taurine (100 mg/kg) did not change the half-life of cystathionine (1.42 +/- 0.33 hr), but significantly increased the half-life of cyst(e)ine (19.1 +/- 0.56 hr). "
04/01/2010 - "Cystathionine beta-synthase (EC 4.2.1.22), and cystathionine gamma-lyase (CSE; EC 4.4.1.1), also known as cystathionine, can generate H(2)S from cyst(e)ine. "
11/01/1997 - "The inhibition of gamma-cystathionase was reflected in the blood levels of amino acids, because the L-methionine: L-cyst(e)ine ratio was significantly higher in PPG-treated rats than in control rats; blood concentration of cystathionine was also greater. "
01/01/1967 - "1. In a study of the metabolism of l-[(35)S]methionine in vivo, the labelled sulphur compounds of rat liver and brain were separated first by ion-exchange chromatography into two fractions containing (i) free sulphur amino acids such as methionine, cystathionine, cyst(e)ine and homocyst(e)ine and (ii) glutathione. "
03/31/2009 - "When cells were exposed to high concentrations (10mM) of either of the peroxides, extracellular levels of methionine, cystathionine, and total cyst(e)ine were depleted, mostly due to direct oxidation of sulfur amino acids by peroxides, as indicated by oxidative treatment of culture media alone. "

04/01/2013 - "Cystathionine γ-lyase protects against renal ischemia/reperfusion by modulating oxidative stress."
12/29/1995 - "Cystathionine did not affect blood flow during ischemia-reperfusion. "
12/29/1995 - "We studied the protective effect of cystathionine on acute gastric mucosal injury induced by ischemia-reperfusion in rats. "
12/29/1995 - "Protective effect of cystathionine on acute gastric mucosal injury induced by ischemia-reperfusion in rats."
06/01/2013 - "Recent studies have demonstrated that hydrogen sulfide (H2S) and its endogenous synthase cystathionine-γ-lyase (CSE) confer protection against injury induced by ischemia or reperfusion in various organs. "