Cystadenoma

A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. In some instances, considerable portions of the neoplasm, or even the entire mass, may be cystic. (Stedman, 25th ed)

Also Known As:

Networked: 370 relevant articles (6 outcomes, 31 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Hemangioma (Angioma)
3.	Ascites
4.	Carcinoma (Carcinomatosis)
5.	Cystadenocarcinoma

Experts

1.	Kwiatkowski, David J: 6 articles (03/2015 - 10/2003)
2.	Liu, Jinsong: 4 articles (01/2014 - 10/2004)
3.	Bast, Robert C: 3 articles (10/2013 - 10/2004)
4.	Yu, Yinhua: 3 articles (10/2013 - 10/2004)
5.	Ngan, Hextan Y S: 3 articles (12/2011 - 06/2002)
6.	Cheung, Annie N Y: 3 articles (12/2011 - 06/2002)
7.	Nakanuma, Yasuni: 3 articles (11/2011 - 09/2006)
8.	Zen, Yoh: 3 articles (11/2011 - 09/2006)
9.	Xie, Dan: 3 articles (04/2011 - 01/2005)
10.	Wang, Lin: 3 articles (01/2010 - 10/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cystadenoma:

1.	DNA (Deoxyribonucleic Acid)IBA 06/18/2007 - "We reported earlier that such ovarian cystadenoma cell cultures undergo severe changes in DNA ploidy as they approach crisis and that such changes are an important determinant of crisis independent of telomere attrition. " 01/01/2004 - "In 8 patients with benign and/or borderline ovarian cystadenoma, a complete sequencing of coding fragments of the BRCA2 gene from the peripheral blood DNA was performed. " 01/01/2003 - "The DNA index may be a useful independent factor for predicting the diagnosis of ovarian cystadenoma." 01/01/2003 - "[Prognostic significance of cellular DNA content and AgNOR count in ovarian cystadenoma]." 12/01/1993 - "DNA index and cell cycle distribution might be valuable in reflecting the biological behavior of deteriorating ovarian cystadenoma. "
2.	SilverIBA 01/01/2003 - "It has been showed that cellular DNA content and silver-staining nucleolar organizer region (AgNOR) count were significantly associated with the prognosis of some tumors; however, it is not yet clear whether these two parameters be helpful in predicting the prognosis of ovarian cystadenoma. "
3.	atorvastatin (Lipitor)FDA Link 07/01/2009 - "Following atorvastatin treatment, no significant reduction in tumor size, morphology, or phosphorylated S6 levels was observed for either ENU-associated renal cystadenoma or spontaneous liver hemangioma as compared with the untreated groups. " 07/01/2009 - "We tested atorvastatin as a therapy for (a) ethylnitrosourea (ENU)-enhanced renal cystadenoma and (b) spontaneous liver hemangioma in 129Sv/Jae Tsc2(+/-) mice. "
4.	4-O-carboxymethylascochlorinIBA 01/01/2010 - "It is safe and effective to perform enucleation for well-selected benign pancreatic cystadenomas even if the tumor size is as large as 6 cm, and the endocrine or exocrine function of the pancreas is maintained as much as possible."
5.	GlycogenIBA 09/01/1994 - "Urachal cystadenoma with abundant glycogen: ultrastructural study." 04/01/2002 - "Serous microcystic adenoma (glycogen-rich cystadenoma) of the pancreas: study of 11 cases showing clinicopathological and immunohistochemical correlations." 03/01/1978 - "Microcystic adenomas of the pancreas (glycogen-rich cystadenomas): a clinicopathologic study of 34 cases." 01/01/2010 - "Serous microcystic adenoma (glycogen rich cystadenoma) of the pancreas." 10/01/2002 - "These microcystic lesions were previously known as "glycogen-rich" cystadenomas because of the presence of glycogen within the cyst epithelium. "
6.	ParaffinIBA 10/01/2004 - "Paraffin embedded tissues from 7 normal ovaries, 22 cystadenomas and 42 borderline lesions were analyzed using standard immunoperoxidase and in situ hybridization techniques to assess ARHI expression. " 06/01/2010 - "Here, we detected Rab5a in paraffin-embedded samples of 20 ovarian cysts, 20 benign cystadenomas, and 39 ovarian cancers by immunohistochemistry, and observed that Rab5a expression was significantly higher in ovarian cancer (P = 0.0001). " 01/01/2014 - "To investigate the associations among the number of polyploid giant cancer cells (PGCCs) and vasculogenic mimicry (VM), EZH2 expression, and serous ovarian tumor grade, a total of 80 paraffin-embedded serous ovarian tumor samples including 21 cases of primary carcinoma and their metastatic tumors, 26 cases of primary carcinoma without metastasis, and 12 cases of serous borderline cystadenoma were analyzed. " 05/01/1997 - "Paraffin-embedded sections from the 42 BLOT, 5 normal ovaries, and 10 benign ovarian cystadenomas were stained using monoclonal antibodies against human p53 (DAKO-p53, DAKO, Denmark) and HER-2/neu (C-erB-2, Triton, Parkway, CA). " 12/01/2014 - "Immunoblotting and immunohistochemical (IHC) methods were used to determine huMETCAM/MUC18 expression in lysates of frozen and formalin-fixed, paraffin-embedded tissue sections of normal human ovaries, and ovarian (benign) cystadenomas, carcinomas and metastatic lesions. "
7.	Proteins (Proteins, Gene)IBA 07/01/2003 - "Ovarian cystadenoma did not frequently overexpress these proteins, suggesting that the expression of these proteins is associated with malignancy. " 01/01/2010 - "On immunohistochemical examinations it was found a significantly higher immunoexpression of both examined proteins in invasive serous ovarian cancers than in cystadenomas. " 02/01/2014 - "The aim of the study was to evaluate the expression of proapoptotic proteins p53 and p21 in cystadenomas, borderline tumors and ovarian cancers. " 06/01/2000 - "We analyzed the expression of these proteins in 19 cystadenomas (8 serous and 11 mucinous), 40 borderline tumors (31 serous and 9 mucinous), and 18 serous carcinomas of the ovary. " 08/01/1994 - "In human ovarian tumors, data obtained show that pS2 transcripts and proteins are present in all mucinous cystadenomas studied and at a lower frequency in endometrioid cystadenomas. "
8.	Glycoproteins (Glycoprotein)IBA 04/02/2002 - "A potential tetrasaccharide ligand for E-selectin, (Na(+-)O(3)SO-3)Galbeta-(1-->4)[Fucalpha-(1-->3)]Glcbeta-(1-->6)Gal, an analogue of the ovarian cystadenoma glycoprotein tetrasaccharide fragment, was synthesized in a highly practical way." 01/01/1990 - "1. Perchloric acid-soluble glycoprotein fractions (PASFs) were separated, in yields of 180-610 mg per 100 ml of cyst fluid, from the cyst fluids of human ovarian cystadenomas (OCAs) in benign and borderline and ovarian clear cell carcinoma (OCC) in malignant, and then identified as glycoproteins with 19.1-69.5% carbohydrate by their chemical composition analyses. " 01/21/1994 - "In earlier studies of oligosaccharide probes (neoglycolipids) generated from an ovarian cystadenoma glycoprotein, one of the components that strongly supported binding of the endothelial adhesion molecule, E-selectin, was identified as an equimolar mixture of tetrasaccharides of blood group Le(a) and Le(x) type sulfated at position 3 of the outer galactose (C.-T. " 09/29/1992 - "This report is concerned with identification of a new class of oligosaccharide ligand--sulfate-containing--for the human E-selectin molecule from among oligosaccharides on an ovarian cystadenoma glycoprotein. " 02/01/1993 - "On the basis of the facts that Vgu glycoproteins which react with either VGA or VUA but not with anti-M and -N antibodies and were not detected in human normal organ tissues and sera, were separated and identified as mucin-type glycoproteins with very high molecular weights from human cancerous organ tissues, ascitic fluids of cancer patients and cyst fluids of human ovarian cystadenoma in malignant, it was concluded that Vgu glycoproteins are new tumor-associated substances."
9.	Estrogens (Estrogen)FDA Link 08/01/1988 - "This is the first case of biliary cystadenoma in which the estrogen receptor content was increased. " 01/01/2014 - "Mouse model studies also showed increased expression of AdPLA2 in xenograft tumors, estrogen-induced lung metastatic lesions of Tsc2 null leiomyoma-derived cells, and spontaneous renal cystadenomas from Tsc2+/- mice. " 03/01/2006 - "Tissue was tested with a panel of probes including estrogen and progesterone receptors and compared to pancreatic and ovarian cystadenomas. " 08/01/1988 - "Oral contraceptives and intrahepatic biliary cystadenoma having an increased level of estrogen receptor." 11/01/1998 - "However, in cystadenomas and borderline tumors, both fibulin-1 and ERalpha protein levels increased, in comparison with normal ovaries, suggesting an effect of estrogens in the early steps of tumorigenesis. "
10.	Monoclonal AntibodiesIBA 02/01/1991 - "To investigate whether early changes in the transformation of normal ovarian epithelial cells into tumor cells can be detected with monoclonal antibodies, a comparative immunohistochemical study was performed on normal human ovarian mesothelial cells, cystomas, cystadenomas, ovarian carcinomas, as well as granulosa cell tumor. " 05/01/1997 - "Paraffin-embedded sections from the 42 BLOT, 5 normal ovaries, and 10 benign ovarian cystadenomas were stained using monoclonal antibodies against human p53 (DAKO-p53, DAKO, Denmark) and HER-2/neu (C-erB-2, Triton, Parkway, CA). " 02/01/1998 - "To analyze the relationship between varied degrees of trypsin expression and malignant behavior of ovarian tumors, immunohistochemical studies with monoclonal antibodies to human trypsin and clinicopathologic analysis were performed in human ovarian carcinomas, low-malignant-potential tumors, and benign cystadenomas. " 02/01/1991 - "Using monoclonal antibodies against different keratin subtypes, it was shown that mesothelial cells, ovarian cysts, cystadenomas, and carcinomas all reacted positively with broad-spectrum anti-keratin monoclonal antibodies (MAbs), as well as with MAbs to keratins 7, 8, 18, and 19. "

Therapies and Procedures

1.	Hepatectomy 04/21/2009 - "Left hepatectomy was performed and the patient was symptom-free during a 6-mo follow-up period, suggesting that imaging examination is the major diagnostic method of hepatobiliary cystadenoma, and operation is its best treatment modality." 03/01/2013 - "All patients with hepatobiliary cystadenoma were treated by partial hepatectomy. " 07/01/2011 - "Ruptured biliary cystadenoma managed by angiographic embolization and interval partial hepatectomy." 02/01/1979 - "The authors describe one case of cystadenoma of the bile ducts removed by left hemi-hepatectomy. " 05/01/2013 - "We evaluated the following 4 cases: case 1, a 21-year-old woman with a biliary cystadenoma who underwent extended right hepatectomy; case 2, a 39-year-old woman with a biliary cystadenoma who underwent left hepatectomy; case 3, an 80-year-old man with a biliary cystadenoma who underwent left hepatectomy; and case 4, a 61-year-old man with a biliary cystadenocarcinoma revealing papillary proliferation of atypical epithelium and interstitial infiltrates who underwent left hepatectomy. "
2.	Pancreaticoduodenectomy 12/29/1950 - "[Cystadenoma of the head of the pancreas cured by duodenopancreatectomy]." 03/01/2008 - "The histopathological findings of the operative specimen (cephalic pancreatoduodenectomy) revealed a large serous multilocular cystadenoma. " 02/01/1998 - "A pancreaticoduodenectomy was performed for presumed cystadenoma. " 05/01/1998 - "In these older patients, pancreaticoduodenectomy was performed for pancreatic adenocarcinoma (n = 25; 54%), ampullary adenocarcinoma (n = 9; 20%) distal bile duct adenocarcinoma (n = 5; 11%), duodenal adenocarcinoma (n = 2; 4%), cystadenocarcinoma; (n = 2; 4%), cystadenoma (n = 1; 2%), and chronic pancreatitis (n = 2; 4%). "
3.	Surgical Portacaval Shunt (Portacaval Anastomosis) 04/01/1984 - "Location of the outflow block was suprahepatic (vena cava or major hepatic veins) in 13 patients and intrahepatic in 4. In five patients, a side-to-side portacaval shunt was effective in dissipating ascites with restoration to a normal lifestyle, as were transatrial fracture of a caval web (one patient) and resection of a huge cystadenoma of the liver (one patient). "
4.	Laparotomy 01/01/2009 - "Laparotomy confirmed the contrast enhanced computed tomography findings and histology revealed an intrahepatic mucinous biliary cystadenoma. " 01/01/2006 - "Emergency laparotomy for misdiagnosed biliary cystadenoma originating from caudate lobe." 08/01/2005 - "Cystadenoma and laparoscopic surgery for hepatic cystic disease: a need for laparotomy?" 08/01/1988 - "At laparotomy, a large cystic mass was resected from the left hepatic lobe, and diagnosed as biliary cystadenoma. " 04/01/2001 - "Hand-assisted laparoscopic distal pancreatectomy with minilaparotomy for distal pancreatic cystadenoma."
5.	Appendectomy 06/01/1994 - "Appendectomy is the treatment of retention AM and cystadenoma. " 11/01/1992 - "The three patients with cystadenomas remain free of disease after appendectomy. " 11/01/2014 - "Appendectomy is used for simple mucocele or for cystadenoma. " 05/01/2014 - "Appendectomy is used for simple mucocele or for cystadenoma. " 08/14/2005 - "Appendectomy is used for simple mucocele or for cystadenoma. "