Cyproheptadine (Periactin)

04/01/1977 - "The weekly intratumor induction of PLA in McC3 tumors resulted in the complete regression of a significant number of the tumors, and this therapeutic effect was eliminated by cyproheptadine treatment. "
12/01/2013 - "Recent studies revealed that the anti-allergic cyproheptadine displays anti-blood cancer activity. "
04/01/1987 - "A 44-year-old female with Cushing's disease associated with a pituitary macroadenoma was treated with cyproheptadine, 24 mg per day, after partial surgical resection of the tumor. "
08/01/2008 - "In mouse models of myeloma and leukemia, cyproheptadine inhibited tumor growth without significant toxicity. "
01/01/2016 - "Cyproheptadine, a serotonin antagonist, has recently been reported to function as a novel therapeutic agent by inhibiting PI3K/AKT signaling in several human cancers. "

06/01/2009 - "Alternative managements by prescribing cyproheptadine as an appetite stimulant resulted in significant improvement of feeding behaviors and weight gain."
01/01/1987 - "These findings should be considered preliminary because of the small number of patients, but suggest that weight gain induced by cyproheptadine results in improved linear growth in patients given GH and that this drug may be useful in optimizing the response to GH therapy."
03/01/1970 - "Studies on mechanism of cyproheptadine-induced weight gain in human subjects."
03/01/2012 - "Average weight gain was 0.67 kg in the placebo group and 1.61 kg in the cyproheptadine group (p = 0.036). "
01/01/2004 - "Cyproheptadine has been shown in medical samples to stimulate weight gain. "

01/01/2013 - "Cyproheptadine hydrochloride (CH) is rarely used to treat adult patients with migraine in Japan because it causes sleepiness. "
01/01/2013 - "Preventive effect of cyproheptadine hydrochloride in refractory patients with frequent migraine."
12/01/2010 - "Since her symptoms were well controlled by cyproheptadine, migraine-like attacks were considered. "
11/01/2002 - "On the other hand, cyproheptadine hydrochloride could completely prevent recurrent attacks of ophthalmoplegic migraine. "
11/01/2002 - "[MRI findings and effectiveness of cyproheptadine in two patients with ophthalmoplegic migraine]."

06/01/2000 - "The symptoms included malaise, cardiac arrhythmia, sudation, hyperreflexia, sialosis, diarrhea and were improved by cyproheptadine. "
01/01/1992 - "Treatment with cimetidine (H2 receptor antagonist) resulted in diarrhea, however, the addition of cyproheptadine (H1 receptor antagonist) was beneficial in amelioration of the cutaneous symptoms of mastocytosis. "
01/01/1981 - "Of the various drugs only cyproheptadine, a serotonin antagonist, and piribedil, a dopamine agonist, reduced the frequency of jumping (but not of diarrhea or ptosis) when administered with morphine during development of dependence. "
08/01/1979 - "The interaction of the antidiarrheal agents morphine, propantheline bromide and cyproheptadine on the course of PGF2 alpha-induced diarrhea in mice was studied, as were the effects of naloxone on PGF2 alpha-, methacholine-, and 5-hydroxytryptophan-induced diarrhea. "
09/01/1989 - "The analysis covers the use of enzymes, cholinergic blocking agents, cyproheptadine hydrochloride, amitriptyline hydrochloride, L-Dopa, diphenoxylic acids and opioids in dumping syndrome; benzohexonium and metoclopramide in gastrostasis; diphenoacids and opioids in postvagotomy diarrhea. "

01/01/1998 - "On the basis of pharmacokinetic parameters determined in this study, the oral form of cyproheptadine appears to be suitable for use in clinical trials to treat anorexia in cats. "
01/01/2013 - "Currently, the most widely prescribed medication for anorexia is cyproheptadine hydrochloride. "
11/01/1994 - "Cyproheptadine in severe anorexia."
02/15/1982 - "These results provide further evidence that under certain conditions cyproheptadine, which is used as an orectic agent in man, can produce anorexia."
01/01/1981 - "Among the drugs tested to counteract this anorexia only cyproheptadine shows a modest effect. "