Adenoid Cystic Carcinoma (Cylindroma)

Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)

Also Known As:

Networked: 1096 relevant articles (38 outcomes, 155 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Neoplasm Metastasis (Metastasis)
3.	Adenocarcinoma
4.	Melanoma (Melanoma, Malignant)
5.	Sarcoma (Soft Tissue Sarcoma)

Experts

1.	Debus, Jürgen: 11 articles (09/2015 - 05/2003)
2.	Wang, Jie: 9 articles (11/2014 - 09/2003)
3.	Sun, Zhi-Jun: 8 articles (09/2015 - 07/2010)
4.	Tian, Zhen: 8 articles (08/2015 - 07/2006)
5.	Lei, Delin: 7 articles (01/2016 - 04/2006)
6.	Li, Sheng-Lin: 7 articles (09/2015 - 01/2009)
7.	Jensen, Alexandra D: 7 articles (09/2015 - 01/2010)
8.	Münter, Marc W: 7 articles (09/2015 - 01/2010)
9.	Zhao, Yi-Fang: 7 articles (09/2015 - 07/2010)
10.	Li, Jiang: 7 articles (08/2015 - 07/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Adenoid Cystic Carcinoma:

1.	Cisplatin (Platino)FDA LinkGeneric 11/01/2013 - "Inhibition of autophagy enhances cisplatin cytotoxicity in human adenoid cystic carcinoma cells of salivary glands." 07/01/1997 - "This cisplatin/5-FU regimen would appear to produce a low rate of objective response but useful palliative benefits in advanced symptomatic adenoid cystic carcinoma. " 04/01/1982 - "Intra-arterial cisplatin treatment of adenoid cystic carcinoma." 12/01/1981 - "Cisplatin therapy for adenoid cystic carcinoma." 09/01/1981 - "[Intraarterial therapy of maxillary adenoid cystic carcinoma using cis-platinum (author's transl)]."
2.	CarbonIBA 01/01/2011 - "Local control in R2-resected adenoid cystic carcinoma was already improved with a combination of IMRT and carbon ion boost at only mild side-effects, hence this treatment was also offered to patients with MSGT and microscopic residual disease (R1) or perineural spread (Pn+). " 02/01/2015 - "Re-irradiation of adenoid cystic carcinoma: analysis and evaluation of outcome in 52 consecutive patients treated with raster-scanned carbon ion therapy." 05/01/2003 - "Optimization of radiation therapy for locally advanced adenoid cystic carcinomas with infiltration of the skull base using photon intensity-modulated radiation therapy (IMRT) and a carbon ion boost." 06/01/2003 - "To investigate clinical feasibility and toxicity of combined photon and carbon ion radiotherapy in locally advanced adenoid cystic carcinomas (ACC) within a prospective Phase I/II trial. " 09/01/2015 - "Combined intensity-modulated radiotherapy plus raster-scanned carbon ion boost for advanced adenoid cystic carcinoma of the head and neck results in superior locoregional control and overall survival."
3.	Doxorubicin (Adriamycin)FDA LinkGeneric 05/01/1979 - "Partial remission of advanced adenoid cystic carcinoma obtained with adriamycin: a case report with a review of the literature." 05/01/1979 - "We achieved a partial remission with adriamycin in a patient with advanced metastases of adenoid cystic carcinoma. " 04/15/2014 - "Finally, ASF1a-depleted cancer cells are more sensitive to doxorubicin, suggesting that the 7%-10% of prostate adenocarcinomas and adenoid cystic carcinomas reported to have homozygous deletion or significant underexpression of ASF1a should be tested for high sensitivity to doxorubicin. " 08/01/2011 - "A phase 2 trial of bortezomib followed by the addition of doxorubicin at progression in patients with recurrent or metastatic adenoid cystic carcinoma of the head and neck: a trial of the Eastern Cooperative Oncology Group (E1303)." 03/01/1998 - "Two patients with extensive adenocystic carcinoma of the lacrimal gland were treated with intracarotid cisplatin and intravenous doxorubicin hydrochloride prior to orbital exenteration. "
4.	IonsIBA 01/01/2010 - "Tumors that appear to respond favorably to carbon ions include locally advanced tumors as well as histologically non-squamous cell tumor types such as adenocarcinoma, adenoid cystic carcinoma, malignant melanoma, hepatoma, and bone/soft tissue sarcoma. " 01/01/2007 - "Tumors that appear to respond favorably to carbon ions include locally advanced tumors and those with histologically non-squamous cell type of tumors such as adenocarcinoma, adenoid cystic carcinoma, malignant melanoma, hepatoma, and bone/soft tissue sarcoma. " 12/01/2014 - "The aim of this study was to retrospectively analyse the outcomes of cases of adenoid cystic carcinomas (ACCs) of the head and neck that were treated at a single institution with particle therapy consisting of either protons or carbon ions. " 12/01/2014 - "Treatment outcomes of particle radiotherapy using protons or carbon ions as a single-modality therapy for adenoid cystic carcinoma of the head and neck."
5.	Fluorouracil (Carac)FDA LinkGeneric 06/01/1964 - "INFUSION OF 5-FLUOROURACIL IN CYLINDROMA TREATMENT." 02/01/2014 - "[Study on garlic oil combined with 5-FU induced apoptosis of adenoid cystic carcinoma cell line ACC-M]." 02/01/2014 - "To observe the effect of garlic oil combined with 5-FU induced apoptosis of adenoid cystic carcinoma cell line ACC-M. " 08/01/2004 - "[Combining of TNP-470 and 5-Fu in inhibition of adenoid cystic carcinoma in nude mice model]." 07/01/1997 - "Cisplatin and 5-fluorouracil for symptom control in advanced salivary adenoid cystic carcinoma."
6.	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/01/2011 - "Efficacy of sorafenib, a multi-tyrosine kinase inhibitor, in an adenoid cystic carcinoma metastatic to the lung: case report and review of literature." 10/01/2009 - "Our study raises a prospect of correlation of c-kit mutation and a potential treatment of adenoid cystic carcinoma with tyrosine kinase inhibitor (imatinib)." 04/01/2008 - "To investigate the molecular mechanism of cell apoptosis induced by tyrosine protein kinase inhibitor, genistein, in human salivary adenoid cystic carcinoma cell line SACC-83. " 02/01/2007 - "To investigate the anti-proliferation effect of tyrosine protein kinase inhibitor, Genistein, on human salivary adenoid cystic carcinoma cell line SACC-83, and its effect on Survivin expression. " 04/01/2006 - "Nerve growth factor and tyrosine kinase A in human salivary adenoid cystic carcinoma: expression patterns and effects on in vitro invasive behavior."
7.	sorafenib (BAY 43-9006)FDA Link 02/01/2015 - "Phase II trial of sorafenib in advanced salivary adenoid cystic carcinoma of the head and neck." 01/01/2011 - "Efficacy of sorafenib, a multi-tyrosine kinase inhibitor, in an adenoid cystic carcinoma metastatic to the lung: case report and review of literature." 04/01/2014 - "Lenalidomide and sorafenib was well tolerated and associated with disease stabilization for ≥6 months in patients with melanoma, adenoid cystic carcinoma, and ovarian adenocarcinoma." 01/01/2011 - "In this case report, we present a 59-year-old Caucasian female with refractory adenoid cystic carcinoma of the maxilla metastatic to the lung that responded to sorafenib, a novel multi-tyrosine kinase inhibitor, which targets angiogenesis, Raf kinase pathway, platelet-derived growth factor Ret, and c-Kit. "
8.	vinorelbine (Navelbine)FDA LinkGeneric 10/01/1998 - "Twenty patients (13 males, 7 females, median age 61 years, range 27-74) with recurrent adenocarcinoma-like tumors of major (10 patients) and minor (10 patients) salivary gland origin (13 adenoid cystic carcinoma, 5 adenocarcinoma, 1 malignant mixed tumor, 1 undifferentiated carcinoma) were treated with vinorelbine at the dose of 30 mg/m2 i.v. weekly. " 08/01/2010 - "We report a case of a 65-year-old man with metastatic primary cutaneous adenoid cystic carcinoma that was effectively treated by combination chemotherapy with cisplatin (CDDP) plus vinorelbine(VNR). " 08/01/2010 - "[Combined chemotherapy with cisplatin plus vinorelbine showed efficacy in a case of metastatic primary cutaneous adenoid cystic carcinoma]." 01/01/2007 - "Fifty-seven patients with stage III NSCLC were included in this phase II study: median age 56 years (range 44-71), males / females 49/8, ECOG performance status (PS) 1/2=27/30, stage IIIA/ IIIB 11/46, squamous cell carcinoma 44, adenocarcinoma 7, adenoid cystic carcinoma 1 and large cell carcinoma 5. Treatment consisted of 2 cycles of chemotherapy with vinorelbine and cisplatin or carboplatin, given concurrently with RT, followed by 2-4 more cycles of consolidation chemotherapy with the same drugs. "
9.	Methionine (L-Methionine)FDA Link 01/01/2013 - "Accuracy of methionine-PET in predicting the efficacy of heavy-particle therapy on primary adenoid cystic carcinomas of the head and neck." 06/15/1995 - "Fifteen patients with head and neck cancer (13 with squamous cell carcinoma, 1 with adenocystic carcinoma, and 1 with paranasal plasmocytoma) underwent a PET study with [11C]-methionine both before and after preoperative radiotherapy to the total tumor dose of 61-73 Gy. Twelve primary and 12 metastatic tumor sites were within the field of view. " 01/01/2013 - "We evaluated whether or not PET or PET/CT using L-methyl-[11C]-methionine (MET) can allow for the early prediction of local recurrence and metastasis, as well as the prognosis (disease-specific survival), in patients with adenoid cystic carcinoma of the head and neck treated by carbon ion beam radiotherapy. "
10.	Nelfinavir (Viracept)FDA Link 05/01/2015 - "Efficacy of nelfinavir as monotherapy in refractory adenoid cystic carcinoma: Results of a phase II clinical trial." 10/01/2012 - "Nelfinavir treatment of adenoid cystic carcinoma: A case report."

Therapies and Procedures

1.	Radiotherapy 02/01/1993 - "Our experience suggests that surgical treatment and adjunctive radiotherapy is beneficial in patients with adenoid cystic carcinoma." 10/01/1984 - "Our experience suggests that adjunctive radiotherapy is beneficial in patients with adenoid cystic carcinoma." 08/01/1996 - "To examine the efficacy of fast neutron radiotherapy for the treatment of patients with locally advanced, adenoid cystic carcinoma of minor salivary glands and to identify prognostic variables associated with local control, overall survival, and cause specific survival. " 10/01/2008 - "Fast neutron radiotherapy is an effective treatment for locally advanced adenoid cystic carcinoma of the trachea, with acceptable treatment-related toxicity." 08/01/2000 - "Wide local excision and radical postoperative radiotherapy seems to be an effective treatment for adenoid cystic carcinoma of the salivary glands."
2.	Drug Therapy (Chemotherapy) 12/01/1987 - "After discussion of problems, conservative surgery is indicated as the most suitable treatment in these cases, considering that chemotherapy and radiation therapy alone are not highly effective in treating cylindromas and, furthermore, they are contraindicated because of the young age of the patient." 09/01/1981 - "Within four weeks--the entire dosage of Cisplatinum was 400 mg--the patient came into complete remission, clinically and histologically, suggesting that the adenoid cystic carcinoma may be more susceptible to chemotherapy than thought up to the present day. " 03/01/1998 - "To our knowledge, this is the first report of the efficacy of neoadjuvant intracarotid chemotherapy in the treatment of an advanced adenocystic carcinoma of the lacrimal gland. " 11/01/2013 - "However, there is currently no study on the role of autophagy in chemotherapy of adenoid cystic carcinoma (ACC) of human salivary glands. " 11/01/2010 - "Data on chemotherapy treatment for adenoid cystic carcinoma consist of phase II trials. "
3.	Adjuvant Radiotherapy 09/01/2012 - "Surgery and adjuvant radiotherapy offer the best chance for cure for patients with resectable adenoid cystic carcinomas of the head and neck. " 01/01/2016 - "Early diagnosis, experienced surgical treatments, and postoperative adjuvant radiotherapy for patients with positive margins may contribute to the improved survival of patients with primary tracheal adenoid cystic carcinoma." 03/01/2010 - "A unique case of multifocal adenoid cystic carcinoma of the breast presenting as a painful and well-defined lump and treated with conservative surgery with adjuvant radiotherapy is reported. " 09/01/2003 - "Postoperative adjuvant radiotherapy for adenoid cystic carcinoma of the head and neck: treatment results and prognostic factors." 10/01/2015 - "Adjuvant Radiotherapy with Three-Dimensional Conformal Radiotherapy of Lacrimal Gland Adenoid Cystic Carcinoma."
4.	Brachytherapy 06/01/2013 - "This retrospective study was to evaluate the local control and survival of (125)I brachytherapy for recurrent and/or locally advanced adenoid cystic carcinoma (ACC) of the oral and maxillofacial region. " 06/01/2013 - "125I brachytherapy alone for recurrent or locally advanced adenoid cystic carcinoma of the oral and maxillofacial region." 03/01/2008 - "HDR-Ir brachytherapy is an effective method for the treatment of local recurrences of an adenoid cystic carcinoma, even after preradiotherapy. " 02/01/2003 - "A 40-year old man, 9 months' status postresection of a bronchial adenoid cystic carcinoma, was diagnosed by clinical evaluation and fine-needle aspiration biopsy and treated with palladium-103 ophthalmic plaque brachytherapy. " 11/01/1991 - "This is probably the first report of endobronchial brachytherapy being applied for recurrent adenoid cystic carcinoma of the lung with a good response. "
5.	Combination Drug Therapy (Combination Chemotherapy) 08/01/1993 - "Combination chemotherapy for a senile patient with adenoid cystic carcinoma of the esophagus: a case report." 03/01/1987 - "The authors conclude that CVF is a well-tolerated combination chemotherapy program with activity in adenoid cystic carcinoma of the head and neck. " 09/01/1984 - "Adenoid cystic carcinoma of the oesophagus: report of a case not responding to combination chemotherapy." 09/01/2012 - "For recurrent and/or metastatic cancer, polychemotherapy (cisplatin based) gives a 25% response rate in adenoid cystic carcinoma and should be used when the disease is overtly in progression. " 06/01/1989 - "Cisplatin combination chemotherapy in squamous cell carcinoma and adenoid cystic carcinoma of the skin."