Cycloleucine

An amino acid formed by cyclization of leucine. It has cytostatic, immunosuppressive and antineoplastic activities.

Also Known As:

Aminocyclopentanecarboxylic Acid; NSC 1026; 1 Aminocyclopentanecarboxylic Acid; Acid, 1-Aminocyclopentanecarboxylic; Acid, Aminocyclopentanecarboxylic; 1-Aminocyclopentanecarboxylic Acid; Cyclopentanecarboxylic acid, 1-amino-

Networked: 48 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cheng, Da: 1 article (01/2022)
2.	Fu, Lei: 1 article (01/2022)
3.	Li, Ying: 1 article (01/2022)
4.	Liu, Yao: 1 article (01/2022)
5.	Mo, Juan: 1 article (01/2022)
6.	Peng, Shifang: 1 article (01/2022)
7.	Wu, Cichun: 1 article (01/2022)
8.	Bouvet, Michael: 1 article (01/2021)
9.	Hamada, Kazuyuki: 1 article (01/2021)
10.	Han, Qinghong: 1 article (01/2021)

Related Diseases

1.	Neoplasms (Cancer) 01/01/1982 - "Phase II study of high-dose intermittent cycloleucine in colorectal malignancies." 08/01/1970 - "Phase II study of 1-aminocyclopentanecarboxylic acid (NSC-1026) in patients with cancer." 12/01/1965 - "Phase I study of 1-aminocyclopentanecarboxylic acid (NSC-1026) in cancer patients." 05/01/1988 - "These results suggest that the small ringsize alicyclic alpha-amino acid analogs containing 3-methyl group such as 3-methyl-1-aminocyclopentanecarboxylic acid (3-MeACPC) may be effective for the early detection of tumors." 08/01/1978 - "The selective affinity of [carboxyl-11C]-1-aminocyclopentanecarboxylic acid (ACPC) for tumor tissue has led us to study the tumor-localizing characteristics of a series of alicyclic alpha-amino acid analogs of ACPC. "
2.	Sarcoma (Soft Tissue Sarcoma) 01/01/1981 - "Lower doses of cycloleucine (200 mg/kg) yielded less toxicity but were less effective against the sarcomas (6% response rate, three of 51 patients). " 03/01/1981 - "Phase II evaluation of cycloleucine in the treatment of patients with disseminated sarcomas." 07/10/1979 - "Cycloleucine (1-aminocyclopentane-1-carboxylic acid) is a potent inhibitor of RNA methylation in B77 sarcoma virus-infected chicken embryo fibroblasts. " 01/01/1981 - "In this patient series, doxorubicin and cycloleucine at a dose of 300 mg/kg both show response rates in the treatment of advanced soft tissue sarcomas of about 15%. " 01/01/1981 - "Comparison of doxorubicin with cycloleucine in the treatment of sarcomas."
3.	Starvation 07/01/1972 - "Hepatic and skeletal muscle transport of cycloleucine during starvation." 01/01/2019 - "Furthermore, cycloleucine treatment or methionine starvation apparently reduced the developmental potential of blastocysts. " 04/01/1993 - "Starvation increases Na(+)-dependent L-alanine uptake and Na(+)-independent cycloleucine uptake by small-intestinal brush-border membrane vesicles. " 07/25/1982 - "The concentration of AdoMet decreased from 0.4 mM to 0.3 mM during starvation but when cycloleucine, an inhibitor of AdoMet synthetase, was used to decrease [AdoMet] by a similar amount in histidine-fed cells there was little change in tumbling frequency. " 04/01/1979 - "There was no starvation-induced increase in the transport of leucine, phenylalanine, lysine, or cycloleucine. "
4.	Cystinuria 11/01/1978 - "Experimental cystinuria: the cycloleucine model. " 12/01/1975 - "Experimental cystinuria: the cycloleucine model. " 07/01/1971 - "[Modification of aminoaciduria in the rat after administration of cycloleucine: comparison with human cystinuria]." 06/15/1978 - "Cycloleucine is a synthetic amino acid which produces, in vivo, biochemical abnoramlities comparable to those seen in human cystinuria-lysinuria. " 12/01/1975 - "The injection of cycloleucine (1-aminocyclopentanecarboxylic acid (ACPC) into rats produces a hyperexcretion of dibasic amino acids and cystine, an aberration resembling cystinuria. "
5.	Subacute Combined Degeneration 06/01/1992 - "Cycloleucine (CL), an inhibitor of methionine adenosyltransferase, has previously been used to produce an experimental model of subacute combined degeneration of the spinal cord. " 06/01/1993 - "Cycloleucine, tellurium, and 1,3-dinitrobenzene provide models of subacute combined degeneration, primary peripheral nerve demyelination, and thiamine deficiency-like lesions, respectively. " 01/01/1986 - "Cells treated with 30 microM sinefungin, which inhibits myelin basic protein methyltransferase in broken cell preparations about 60%, produced ringlike structures that were devoid of multilamellar periodicity and compactness reminiscent of the vacuolated myelin observed in subacute combined degeneration and in nitrous-oxide- or cycloleucine-treated animals in which methyltransferase activity is also inhibited. "

Related Drugs and Biologics

1.	Amino Acids
2.	2-aminoisobutyric acid
3.	S-Adenosylmethionine (Ademetionine)
4.	RNA (Ribonucleic Acid)
5.	Nitrous Oxide (Laughing Gas)
6.	Methyltransferases
7.	Methionine (L-Methionine)
8.	Lysine (L-Lysine)
9.	Cystine (L-Cystine)
10.	Cycloleucine

Related Therapies and Procedures

1.	Therapeutics
2.	Intraperitoneal Injections