Cycasin

Carcinogenic and neurotoxic glycoside occurring in a number of plant species, including Cycas revoluta.

Also Known As:

(Methyl-ONN-azoxy)methyl beta-D-Glucopyranoside; Methylazoxymethanol Glucuronate; Glucuronate, Methylazoxymethanol; Methylazoxymethanol beta D Glucoside; beta-D-Glucoside, Methylazoxymethanol; Methylazoxymethanol beta-D-Glucoside; beta-D-Glucopyranoside, (methyl-ONN-azoxy)methyl

Networked: 51 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Azo Compounds: 333
  - Azoxymethane: 2117
    - Cycasin: 51
      - methylazoxymethyl-beta-D-glucosiduronic acid

Experts

1.	Spencer, Peter S: 4 articles (01/2020 - 01/2011)
2.	Kisby, Glen E: 4 articles (12/2018 - 01/2011)
3.	Palmer, Valerie S: 2 articles (12/2018 - 01/2011)
4.	Fry, Rebecca C: 2 articles (01/2012 - 01/2011)
5.	Moore, Holly: 1 article (12/2013)
6.	Spencer, Peter: 1 article (01/2012)
7.	Bede, Jacqueline C: 1 article (07/2011)
8.	Cubilla-Rios, Luis: 1 article (07/2011)
9.	Ledezma, Julieta: 1 article (07/2011)
10.	Prado, Alberto: 1 article (07/2011)

Related Diseases

1.	Neoplasms (Cancer) 04/01/1986 - "Comparison with carcinogenicity studies indicates a good correlation between the distribution of genotoxic effects as determined in the present studies and the localisation of tumors in various organs of rodents treated with cycasin." 02/01/1967 - "[Histological-histochemical studies on the "interstitial cycasin tumor" of rat kidneys]." 04/01/1991 - "1,2-Dimethylhydrazine-HCl (DMH-2HCl) is derived from the natural toxin cycasin, and is extensively used to induce cancers in experiments with rodents. " 06/01/1985 - "Administration ip of cycasin also gave rise to tumor induction in newborn rats. " 06/01/1985 - "When cycasin was given sc to newborn rats at day 0, tumors were detected in more than 80% of rats of both sexes; kidney tumors were by far the most common. "
2.	Carcinogenesis 06/01/1985 - "Comprehensive studies of carcinogenesis in newborn or preweanling SD rats were conducted under various dose schedules of cycasin (CAS: 14901-08-7) administration. " 05/01/1974 - "[Cycasin carcinogenesis. " 10/01/1971 - "Shift of target organs in cycasin carcinogenesis." 06/01/1970 - "[Carcinogenesis by cycasin, with special reference to the target organs]." 08/01/1991 - "Two cycad neurotoxins are recognized, one of which (cycasin) is known to have long-latency effects (tumorigenesis) on mitotic neurons and replicating cells in other tissues. "
3.	Wilms Tumor (Wilm's Tumor) 01/01/1978 - "Histologic studies indicate that the cycasin-induced Wilms' tumor in the rat is equal to human nephroblastoma in appearance. " 05/01/1968 - "Transplantability of cycasin-induced tumors in rats, with emphasis on nephroblastomas."
4.	Neurodegenerative Diseases (Neurodegenerative Disease) 01/01/2011 - "They also support the hypothesis that early-life exposure to MAM-glucoside (cycasin) has an etiological association with a declining, prototypical neurodegenerative disease seen in Guam, Japan, and New Guinea populations that formerly used the neurotoxic cycad plant for food or medicine, or both. " 01/01/2020 - "ALS/PDC retinal and cerebellar pathology matches persistent retinal and cerebellar dysplasia found in laboratory animals given single in utero or postnatal systemic treatment with cycasin, the principal neurotoxic component in the seed of cycad plants traditionally used for food (Guam) or oral medicine (Kii-Japan), both of which have been linked to the human neurodegenerative disease. " 01/01/2012 - "Six conferences (1962-1972) examined the puzzling neurotoxic and carcinogenic properties of a then-novel toxin [cycasin: methylazoxymethanol (MAM)-β-d-glucoside] in cycad plants used traditionally for food and medicine on Guam where a complex neurodegenerative disease plagued the indigenous population. " 07/01/1992 - "Traditionally processed cycad flours (n = 17) obtained from Chamorro residents of Guam and the adjacent island of Rota at risk for neurodegenerative disease were extracted and analyzed by high-performance liquid chromatography for content of beta-N-methylamino-L-alanine (BMAA) and methyl-azoxymethanol beta-D-glucoside (cycasin). " 09/01/1996 - "Parkinsonism-dementia complex (PDC), a neurodegenerative disorder in the Chamorro, Guam population, has been epidemiologically ascribed to the ingestion of the neurotoxin cycasin. "
5.	Dementia (Dementias) 06/28/1996 - "These data on cycasin, a toxin obtained from the cycad plant (Cycas spp.), are of special interest, since this agent may be implicated in both amyotrophic lateral sclerosis/Parkinson dementia complex and diabetes mellitus in the western Pacific area. " 12/01/2013 - "The neuropathology of amyotrophic lateral sclerosis/parkinsonism-dementia complex includes features suggestive of brain maldevelopment, an experimentally proven property of cycasin attributable to the genotoxic action of its aglycone methylazoxymethanol (MAM). " 09/01/1996 - "Parkinsonism-dementia complex (PDC), a neurodegenerative disorder in the Chamorro, Guam population, has been epidemiologically ascribed to the ingestion of the neurotoxin cycasin. " 07/31/1995 - "The medicinal and food use of seed from the cycad plant (Cycas spp.), which contains the genotoxin cycasin, is a proposed etiological factor for amyotrophic lateral sclerosis/Parkinsonism-dementia complex (ALS/PDC), a prototypical neurodegenerative disease found in the western Pacific. " 07/13/1994 - "The medicinal and food use of seed from the cycad plant (Cycas spp.), which contains the neurotoxin cycasin, is a proposed etiological factor for amyotrophic lateral sclerosis/Parkinsonism dementia complex (ALS/PDC), a prototypical neurodegenerative disease found in the western Pacific. "

Related Drugs and Biologics

1.	Neurotoxins
2.	Glucosides
3.	methylazoxymethanol
4.	Carcinogens
5.	beta-N-methylamino-L-alanine (beta-methylamino-L-alanine)
6.	Glycosides
7.	Cycasin
8.	Alanine (L-Alanine)
9.	macrozamin
10.	Phytochemicals

Related Therapies and Procedures

1.	Oral Medicine
2.	Oral Administration