Cutis Laxa

A group of connective tissue diseases in which skin hangs in loose pendulous folds. It is believed to be associated with decreased elastic tissue formation as well as an abnormality in elastin formation. Cutis laxa is usually a genetic disease, but acquired cases have been reported. (From Dorland, 27th ed)
Also Known As:
Dermatolyses; Dermatolysis; Dermatomegaly
Networked: 202 relevant articles (2 outcomes, 10 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Wounds and Injuries (Trauma)
2. Cicatrix (Scar)
3. Ehlers-Danlos Syndrome (Syndrome, Ehlers-Danlos)
4. Marfan Syndrome (Marfan's Syndrome)
5. Supravalvular Aortic Stenosis (Aortic Supravalvular Stenosis)


1. Morava, Eva: 9 articles (04/2014 - 04/2005)
2. Kornak, Uwe: 7 articles (09/2015 - 01/2008)
3. Urban, Zsolt: 7 articles (05/2014 - 06/2005)
4. Wevers, Ron A: 6 articles (04/2014 - 06/2005)
5. Davis, Elaine C: 5 articles (01/2013 - 05/2003)
6. Mohamed, Miski: 4 articles (04/2014 - 08/2011)
7. Gardeitchik, Thatjana: 4 articles (04/2014 - 08/2011)
8. Kielty, Cay M: 4 articles (01/2013 - 01/2006)
9. De Paepe, Anne: 4 articles (01/2013 - 09/2002)
10. Mecham, Robert P: 4 articles (06/2012 - 05/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cutis Laxa:
1. Botulinum Toxins (Botulinum Toxin)IBA
2. PlasticsIBA
3. ElastinIBA
4. CollagenIBA
01/01/1987 - "Collagen studies in congenital cutis laxa."
01/01/2010 - "Skin biopsy showed fragmentation of the elastic tissue with collagen tissue in the dermis, which was suggestive of Cutis Laxa. "
09/01/1991 - "Normal collagen synthetic activity was observed in the cutis laxa fibroblasts. "
06/15/1976 - "Abnormally soluble collagen is synthesized in vitro not only by skin fibroblasts of Marfan patients but also by those of patients with Ehlers-Danlos type V and cutis laxa. "
09/01/1989 - "Light and electron microscopic studies of skin from patients with inherited connective tissue disorders (e.g., Ehlers-Danlos syndrome, osteogenesis imperfecta, Marfan syndrome, cutis laxa) have led us to the following generalizations about what components change, how individual collagen or elastic fibers are altered and how individual alterations affect overall dermal organization: 1) There is a limited change in the repertoire of collagen fibrils in the skin; 2) there appears to be a greater range of abnormal structure in dermal elastic fibers than in the collagen fibrils; 3) the morphology of the fibroblastic cells may provide clues to the defect in matrix components; 4) similar structural abnormalities result from different molecular defect; 5) a molecular defect in one connective tissue molecule has consequences for the structural properties of other connective tissue components; and 6) although structural alterations in connective tissue fibers are rarely specific for a given disease, there are characteristic patterns of structural change in the matrix that may be used to confirm a diagnosis. "
5. Proline (L-Proline)FDA Link
6. Generalized elastolysisIBA
7. recessive Cutis laxaIBA
8. OxidoreductasesIBA
9. CalciumIBA
10. Collagen Type I (Type I Collagen)IBA

Therapies and Procedures

1. Injections
2. Rhytidoplasty (Facelift)
3. Blepharoplasty
4. Hematopoietic Stem Cell Mobilization
5. Mammaplasty (Breast Reconstruction)