Curare

Plant extracts from several species, including genera STRYCHNOS and Chondodendron, which contain TETRAHYDROISOQUINOLINES that produce PARALYSIS of skeletal muscle. These extracts are toxic and must be used with the administration of artificial respiration.

Networked: 327 relevant articles (6 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Russo, Patrizia: 2 articles (11/2004 - 01/2004)
2.	Falugi, Carla: 2 articles (11/2004 - 01/2004)
3.	Trombino, Sonya: 2 articles (11/2004 - 01/2004)
4.	Cesario, Alfredo: 2 articles (11/2004 - 01/2004)
5.	Montgomery, Erica: 1 article (10/2015)
6.	Pagán, Oné R: 1 article (10/2015)
7.	Deats, Sean: 1 article (10/2015)
8.	Bach, Daniel: 1 article (10/2015)
9.	Baker, Debra: 1 article (10/2015)
10.	Bonnet, L: 1 article (06/2015)

Related Diseases

1.	Tetanus 01/09/1953 - "[Tetanus cured by successive treatment by artificial hibernation and synthetic curare]." 11/01/1990 - "[Curare in the treatment of tetanus]." 04/01/1973 - "Any interference with spindle firing patterns from extrafusal contraction produced by the motor stimulation was removed by differentially blocking the contraction with the drug curare.3. Discharge patterns of spindles in response to a slow stretch of the muscle were compared with the response to the same stretch, but during repetitive stimulation of the motor nerve filament which produced an intrafusal contraction.4. At the initial length, the firing rate of spindles in the twitch muscle was greatly increased by the motor tetanus. " 11/01/1969 - "[Electrocardiographic findings in tetanus patients treated with curare and subjected to intermittent positive respiration. " 03/24/1962 - "[Directions for curare therapy of tetanus]."
2.	Spasm (Spasms) 09/01/1950 - "[Spasm of the glottis and curare]." 10/01/1949 - "The use of curare (d-tubocurarine in oil and wax) in the treatment of muscle spasm in rheumatic disorders." 05/01/1950 - "Curare relieves some of the pain of arthritis due to muscle spasm, but does not bring improvement in motion of the small joints, such as those of the fingers. " 06/01/1983 - "Stiff-man syndrome is characterized clinically by fluctuating muscular stiffness and spasm, and electromyographically by continuous motor unit activity at rest, which is abolished by sleep, general anesthesia, nerve block, curare, and several centrally-acting medications. " 12/01/1946 - "Muscle spasm in acute low back pain and similar syndromes; a new method of treatment with curare (d-tubocurarine in oil and wax)."
3.	Contracture 05/01/1951 - "This is probably due to the contracture of the muscle since the effect is largely eliminated by previous treatment of the muscle with curare. " 02/01/1989 - "The contractures disappeared in the local curare test. " 01/01/1984 - "The initial contracture produced by each is prevented by tetrodotoxin or curare. " 11/01/1982 - "The possibility that fetal movements play a role in the initiation of the bursts of tonic myometrial activity (contractures) that occur throughout the second half of pregnancy in the sheep has been examined by the administration of the curare derivative pancuronium to abolish fetal movement. " 01/01/1991 - "Cocaine caused concentration dependent reduction in amplitude of the nerve AP, muscle AP, and tension response to a single nerve stimulus, and greater reduction in amplitude of these responses to repetitive nerve stimuli at 100 Hz for 0.5 sec. Cocaine caused similar reduction in the muscle AP and tension responses to direct muscle stimulation in the presence or absence of curare, and markedly reduced the overshoot, total potential, and maximum rate of rise and fall of intracellularly recorded muscle AP, without affecting the resting potential, or the contracture responses evoked by caffeine. "
4.	Pain (Aches) 02/01/1996 - "This means that treatment to relieve pain and suffering which coincidentally might bring forward the moment of death by a few hours or days is acceptable (the principle of double effect), but administering a drug such as potassium or curare, with the primary intention of causing death, is not." 11/01/1951 - "[Vitaminized anesthetics, alone or associated with curare, in the treatment of vascular pain of the extremities]." 01/01/1998 - "Three patients with intramedullary lesions (1 ependymoma and 2 cavernomas), initially revealed by pain and followed by neurological deficit, were operated at our institution using peroperative direct medullary electrical stimulations (60 Hz, biphasic square wave pulses with 1 ms/phase, 0.9 mA) under general anesthesia without curare. " 05/01/1950 - "Curare relieves some of the pain of arthritis due to muscle spasm, but does not bring improvement in motion of the small joints, such as those of the fingers. "
5.	Anoxia (Hypoxia) 09/01/1961 - "Curare, anesthetic, narcotic, diffusion hypoxia." 12/01/1960 - "[Influence of curare on the circulatory reactions to anoxia]." 08/01/1992 - "The risk of intraoperative hypoventilation and hypoxemia was eliminated, yet, due to the lack of adequate monitoring techniques the slow recovery from curare, alcuronium or pancuronium neuromuscular blockade was hardly appreciated.(ABSTRACT TRUNCATED AT 400 WORDS)"

Related Drugs and Biologics

1.	Pancuronium (Pavulon)
2.	Alcuronium (Alcuronium Chloride)
3.	Acetylcholine (Acetylcholine Chloride)
4.	Neostigmine (Neostigmine Bromide)
5.	barbituric acid (barbiturate)
6.	Thyroxine (Levothyroxine)
7.	Magnesium
8.	Tubocurarine (Tubocurarine Chloride)
9.	Thiopental (Pentothal)
10.	Nicotine

Related Therapies and Procedures

1.	Artificial Respiration (Mechanical Ventilation)
2.	General Anesthesia
3.	Tourniquets
4.	Anesthesia
5.	Mechanical Ventilators (Ventilator)