Croton Oil

Viscous, nauseating oil obtained from the shrub Croton tiglium (Euphorbaceae). It is a vesicant and skin irritant used as pharmacologic standard for skin inflammation and allergy and causes skin cancer. It was formerly used as an emetic and cathartic with frequent mortality.

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Networked: 568 relevant articles (18 outcomes, 37 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Tubaro, Aurelia: 15 articles (11/2014 - 05/2004)
2.	Sosa, Silvio: 14 articles (11/2014 - 06/2004)
3.	Epifano, Francesco: 6 articles (01/2014 - 05/2004)
4.	Chang, Hyeun Wook: 6 articles (08/2005 - 04/2002)
5.	Kim, Hyun Pyo: 6 articles (08/2005 - 04/2002)
6.	Scio, Elita: 5 articles (09/2015 - 06/2013)
7.	Genovese, Salvatore: 5 articles (01/2014 - 05/2006)
8.	Della Loggia, Roberto: 5 articles (12/2013 - 06/2004)
9.	Curini, Massimo: 5 articles (01/2011 - 05/2004)
10.	Sosa, S: 5 articles (04/2009 - 10/2001)

Related Diseases

1.	Neoplasms (Cancer) 05/01/2010 - "asoka), 30 min prior to the application of croton oil thrice weekly for 20 weeks, caused a significant reduction in the number of tumors per mouse and the percentage of tumor-bearing mice. " 08/01/1988 - "Thus under the circumstances of this study croton oil did promote UV initiated tumor formation but BPO did not. " 04/01/2006 - "The present investigation was undertaken to explore the anti-tumor promoting activity of Rosemarinus officinalis on two-stage skin carcinogenesis, induced by a single topical application of 7, 12-dimethylbenz(a)anthracene and promoted by treatment of croton oil for 15 weeks in Swiss albino mice. " 08/01/1996 - "Primary tumors were induced and promoted concurrently in 35 uPA-/- deficient and 35 uPA+/+ wild-type mice using a single application of 7,12-dimethylbenz(a)anthracene followed by repetitive applications of croton oil. " 07/12/1996 - "Our findings showed that treatment of carcinogen and croton oil exposed mice of Groups III and IV with two different doses of FBPI not only brought about appreciable delay in the appearance of tumors but also significant (P < 0.025-0.001) suppression of tumor incidence at nearly all times of promotion. "
2.	Inflammation 12/01/1999 - "Topically applied emu oil significantly reduced severity of acute auricular inflammation induced by croton oil in mice." 08/01/2015 - "Topical inflammation was induced in ICR mice using croton oil. " 10/31/2013 - "Croton oil administration resulted in severe inflammation. " 01/09/2013 - "Ethanolic extract altered inflammatory parameters on a chronic skin inflammation model induced by repeated applications of croton oil, decreasing ear oedema, epidermal hyperproliferation and cell infiltration. " 01/09/2013 - "Classical models of skin inflammation such as TPA- and croton oil-induced mouse ear oedema were applied in order to verify the potential topical anti-inflammatory activity of the ethanolic extract from flowers of Combretum leprosum. "
3.	Papilloma (Papillomatosis) 01/01/2011 - "Similarly, topical application of extract (1 and 5 mg) effectively ameliorated the croton oil promoted skin papilloma formation. " 02/01/1980 - "Initiation with 7,12-dimethylbenz(a)-anthracene and promotion with croton oil produced in Swiss, A, Balb/c and C3H mice as well as New Zealand rabbits a large number of squamous papillomas. " 10/01/1975 - "When croton oil was administered twice weekly at a 0.25%-dose level, 10.2 papillomas/mouse were induced after 32 weeks of promotion. " 01/01/2010 - "from the day of start of croton oil treatment and continued till the end of the experiment) phases demonstrated significant reduction in cumulative numbers of papillomas and tumor incidence (75%). " 01/01/2009 - "starting from the croton oil application) initiational phase of papillomagenesis caused significant reduction in tumor incidence, tumor yield, tumor burden and cumulative number of papillomas as compared to carcinogen-treated controls. "
4.	Granuloma 12/01/1987 - "In the granuloma pouch induced by the injection of air and croton oil, chronic administration of the drug for 7 days resulted in significant reduction in the volume of exudate and the weight of granulation tissue. " 07/01/1990 - "The present study examines the existence of a similar modulatory effect of CNS on a subacute inflammatory paradigm, the croton oil-induced granuloma pouch in rats. " 09/01/2001 - "In the second model, granuloma pouches were induced by subcutaneous croton oil injection; pouches were either left intact or released from tension by evacuation of the exudate at 14 days. " 08/01/1997 - "To test this hypothesis, we used a granuloma pouch model, where a subcutaneous air sac is created followed by injection of croton oil. " 06/01/1985 - "Among a great many methods examined in mice, only an air-pouch method with Freund's complete adjuvant with 0.1% croton oil obviously induced the granuloma pouch with well-developed vascularization, which a little differed from that seen in rats. "
5.	Body Weight (Weight, Body) 05/01/1987 - "Twenty seven male and 28 female ACI/N rats were given a single intragastric intubation of MAM at a dose of 25 mg/kg body weight, followed by croton oil at 0.25 ml/kg body weight, 3 times a week, by gastric intubation until the termination of this experiment (365 days). " 10/01/2006 - "Animals were divided into following groups: Group I (Controls) given DMBA and croton oil, with no extract ; Group II (treatment) animals treated with Acacia nilotica gum (Group II-a) (800 mg/kg body weight), flowers (Group II-b) (800 mg/kg body weight), or leaves (Group II-c) (800 mg/kg body weight) during the peri- and post initiation periods of DMBA and croton oil application. " 11/01/2003 - "Topical application of the extract at a dose of 5 mg/kg body weight/day for 15 weeks at the peri-initiational stage (i.e., 7 days before and 7 days after DMBA application), promotional stage (i.e., from the time of croton oil application) and both peri and post-initiational stages (i.e., 7 days prior to DMBA application and continued till the end of the experiment) on the shaven backs of the mice recorded a significant reduction in tumor incidence to 50, 33.3 and 16.7% respectively in comparison to the control (i.e., the mice treated with DMBA and croton oil only) where tumor incidence was found to be 81.8%. " 04/01/2003 - "The skin papillomagenesis studies demonstrated a significant decrease (p<0.05 ) in the percentage of mice with papillomas, average number of papillomas per mouse and papillomas per papilloma bearing mouse when the animals received a topical application of the extract at a dose of 5mg/ kg body weight in the peri-initiation phase 7 days before and 7 days after DMBA application, Group II ), promotional phase (from the day of croton oil application and continued till the end of the experiment, Group III ) and both peri and post initiation stages (from 7 days prior to DMBA application and continued till the end of the experiment, Group IV) compared to the control group (Group I ). " 04/01/2000 - "Results of the 5-day rat croton oil ear edema bioassay indicated that, in contrast with the parent compound P, the novel steroidal antedrugs did not significantly alter body weight gain, thymus weights, or plasma corticosterone levels. "

Related Drugs and Biologics

1.	9,10-Dimethyl-1,2-benzanthracene (DMBA)
2.	Carrageenan
3.	Acetone
4.	hydrocortisone acetate (Cortifoam)
5.	Salicylic Acid (2 Hydroxybenzoic Acid)
6.	Erythromycin (Erycette)
7.	Spiramycin
8.	Trichloroacetic Acid
9.	Tretinoin (Retinoic Acid)
10.	Clindamycin (Cleocin)

Related Therapies and Procedures

1.	Oral Administration
2.	Transplants (Transplant)
3.	Subcutaneous Injections
4.	Traditional Medicine (Folk Remedies)
5.	Intravenous Injections