Croton Oil

Viscous, nauseating oil obtained from the shrub Croton tiglium (Euphorbaceae). It is a vesicant and skin irritant used as pharmacologic standard for skin inflammation and allergy and causes skin cancer. It was formerly used as an emetic and cathartic with frequent mortality.
Also Known As:
Oil, Croton; Oils, croton
Networked: 568 relevant articles (18 outcomes, 37 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Tubaro, Aurelia: 15 articles (11/2014 - 05/2004)
2. Sosa, Silvio: 14 articles (11/2014 - 06/2004)
3. Epifano, Francesco: 6 articles (01/2014 - 05/2004)
4. Chang, Hyeun Wook: 6 articles (08/2005 - 04/2002)
5. Kim, Hyun Pyo: 6 articles (08/2005 - 04/2002)
6. Scio, Elita: 5 articles (09/2015 - 06/2013)
7. Genovese, Salvatore: 5 articles (01/2014 - 05/2006)
8. Della Loggia, Roberto: 5 articles (12/2013 - 06/2004)
9. Curini, Massimo: 5 articles (01/2011 - 05/2004)
10. Sosa, S: 5 articles (04/2009 - 10/2001)

Related Diseases

1. Neoplasms (Cancer)
2. Inflammation
3. Papilloma (Papillomatosis)
4. Granuloma
5. Body Weight (Weight, Body)
05/01/1987 - "Twenty seven male and 28 female ACI/N rats were given a single intragastric intubation of MAM at a dose of 25 mg/kg body weight, followed by croton oil at 0.25 ml/kg body weight, 3 times a week, by gastric intubation until the termination of this experiment (365 days). "
10/01/2006 - "Animals were divided into following groups: Group I (Controls) given DMBA and croton oil, with no extract ; Group II (treatment) animals treated with Acacia nilotica gum (Group II-a) (800 mg/kg body weight), flowers (Group II-b) (800 mg/kg body weight), or leaves (Group II-c) (800 mg/kg body weight) during the peri- and post initiation periods of DMBA and croton oil application. "
11/01/2003 - "Topical application of the extract at a dose of 5 mg/kg body weight/day for 15 weeks at the peri-initiational stage (i.e., 7 days before and 7 days after DMBA application), promotional stage (i.e., from the time of croton oil application) and both peri and post-initiational stages (i.e., 7 days prior to DMBA application and continued till the end of the experiment) on the shaven backs of the mice recorded a significant reduction in tumor incidence to 50, 33.3 and 16.7% respectively in comparison to the control (i.e., the mice treated with DMBA and croton oil only) where tumor incidence was found to be 81.8%. "
04/01/2003 - "The skin papillomagenesis studies demonstrated a significant decrease (p<0.05 ) in the percentage of mice with papillomas, average number of papillomas per mouse and papillomas per papilloma bearing mouse when the animals received a topical application of the extract at a dose of 5mg/ kg body weight in the peri-initiation phase 7 days before and 7 days after DMBA application, Group II ), promotional phase (from the day of croton oil application and continued till the end of the experiment, Group III ) and both peri and post initiation stages (from 7 days prior to DMBA application and continued till the end of the experiment, Group IV) compared to the control group (Group I ). "
04/01/2000 - "Results of the 5-day rat croton oil ear edema bioassay indicated that, in contrast with the parent compound P, the novel steroidal antedrugs did not significantly alter body weight gain, thymus weights, or plasma corticosterone levels. "

Related Drugs and Biologics

1. 9,10-Dimethyl-1,2-benzanthracene (DMBA)
2. Carrageenan
3. Acetone
4. hydrocortisone acetate (Cortifoam)
5. Salicylic Acid (2 Hydroxybenzoic Acid)
6. Erythromycin (Erycette)
7. Spiramycin
8. Trichloroacetic Acid
9. Tretinoin (Retinoic Acid)
10. Clindamycin (Cleocin)

Related Therapies and Procedures

1. Oral Administration
2. Transplants (Transplant)
3. Subcutaneous Injections
4. Traditional Medicine (Folk Remedies)
5. Intravenous Injections