Cross-Linking Reagents

Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other.

Also Known As:

Networked: 45 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Conejo-Cuevas, Guillermo: 1 article (03/2022)
2.	Gartziandia, Oihane: 1 article (03/2022)
3.	Huguet-Casquero, Amaia: 1 article (03/2022)
4.	Pérez-González, Raul: 1 article (03/2022)
5.	Pérez-Álvarez, Leyre: 1 article (03/2022)
6.	Ruiz-Rubio, Leire: 1 article (03/2022)
7.	Sáez-Martínez, Virginia: 1 article (03/2022)
8.	Chen, Ravit: 1 article (10/2019)
9.	Columbus, Ishay: 1 article (10/2019)
10.	Dagan, Shai: 1 article (10/2019)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2015 - "Here, we suggest that the tetravalent anti-DR5 antibody can induce apoptosis of cancer cells independent of cross-linking reagent. " 03/01/2015 - "Some antibodies to DR4 or DR5 do not have anti-tumor ability without cross-linking but exhibit anti-tumor ability in the presence of a cross-linking reagent. " 12/10/1999 - "Bi- and tri-specific multimers can be formed by association of different scFv molecules and, in the first examples, have been designed as cross-linking reagents for T-cell recruitment into tumors (immunotherapy) and as red blood cell agglutination reagents (immunodiagnostics)." 05/01/1985 - "To determine directly whether cell surface fibronectin influences the metastatic potential of solid tumors, we chemically crosslinked fibronectin to B16 murine melanoma cells using a photosensitive heterobifunctional crosslinking reagent, N-succinimidyl-4-azidophenyl-1,3 dithiopropionate (SADP). " 11/23/1987 - "We report here such an analysis for immunoconjugates consisting of a monoclonal anti-tumor antibody (MoAb) and cobra venom factor (CVF), the complement-activating glycoprotein from cobra venom, synthesized with the heterobifunctional crosslinking reagent N-succinimidyl-3-(2-pyridyldithio)propionate (SPDP). "
2.	Neuroblastoma 09/01/2008 - "To test this hypothesis in vivo, differentiated N1E-115 neuroblastoma cells were labeled with [(35)S]-amino acids and were treated with a cleavable crosslinking reagent. " 03/06/1981 - "The cross-linking reagent, 1,5-difluoro-2,4-dinitrobenzene, was a potent inactivator of ecto-ATPase of C6 glioblastoma, IMR-32 neuroblastoma and of a primary rat astroblast cell line (RB). " 01/01/2000 - "Four neural cell adhesion molecules CD9, CD24, L1 and N-CAM are associated in the surface membrane of cultured neuroblastoma cells as studied by chemical cross-linking with bifunctional reagent 3,3'-dithiobis (sulphosuccinimidyl-propionate) followed by a subsequent immunodetection using antibodies directed against the above molecules. "
3.	Melanoma (Melanoma, Malignant) 05/01/1985 - "To determine directly whether cell surface fibronectin influences the metastatic potential of solid tumors, we chemically crosslinked fibronectin to B16 murine melanoma cells using a photosensitive heterobifunctional crosslinking reagent, N-succinimidyl-4-azidophenyl-1,3 dithiopropionate (SADP). " 12/01/1981 - "The functionally C3b-like glycoprotein of cobra venom was linked to a murine monoclonal Ab directed to a human melanoma-associated antigen by a disulfide bond, by using a heterobifunctional crosslinking reagent. " 11/01/1999 - "Conjugates of the L49 monoclonal antibody (binds to the p97 antigen on melanomas and carcinomas) were formed by attaching Enterobacter cloacae beta-lactamase (bL) to the L49-Fab' fragment using a heterobifunctional cross-linking reagent or by linking the enzyme to L49-sFv using DNA recombinant technology. "
4.	Wounds and Injuries (Trauma) 08/01/2007 - "Immediate bonding of cartilage wounds by chemical cross-linking reagents might be a useful alternative tool. " 03/17/2022 - "Spontaneously formed hydrogels are attracting increasing interest as injectable or wound dressing materials because they do not require additional reactions or toxic crosslinking reagents. "
5.	Leukemia 01/01/1985 - "Cross-linking reagents were used to further characterize the murine B cell receptor for the Fc portion of IgE (Fc epsilon R) and compare this receptor to the well-characterized high-affinity Fc epsilon R on rat basophilic leukemia (RBL) cells. " 05/29/1992 - "In order to elucidate the possible quarternary structure/function relationship of P-glycoprotein, we treated multidrug-resistant human leukemia K562/ADM cells with the crosslinking reagent, disuccinimidyl suberate. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Antibodies
3.	Glycoproteins (Glycoprotein)
4.	Glutaral (Glutaraldehyde)
5.	Esters
6.	Antigens
7.	Monoclonal Antibodies
8.	Hydrogels
9.	Reactive Oxygen Species (Oxygen Radicals)
10.	Solutions

Related Therapies and Procedures

1.	Photochemotherapy (Photodynamic Therapy)
2.	Injections
3.	Immunotherapy
4.	Electrodes (Electrode)