Crisscross Heart

A developmental malformation of the heart characterized by a twisted but not defective atrioventicular connection. The abnormal rotation of the ventricular mass around its long axis results in the crossing of the inflow streams of the two ventricles. Other features include hypoplasia of the TRICUSPID VALVE and RIGHT VENTRICLE.

Also Known As:

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Transposition of Great Vessels (Great Vessels Transposition)
2.	Dextrocardia
3.	Tricuspid Atresia
4.	Pulmonary Atresia (Pulmonary Valve Atresia)
5.	Tricuspid Valve Stenosis

Experts

1.	Mingarelli, Rita: 1 article (10/2010)
2.	Marino, Bruno: 1 article (10/2010)
3.	Digilio, Maria Cristina: 1 article (10/2010)
4.	De Luca, Alessandro: 1 article (10/2010)
5.	De Zorzi, Andrea: 1 article (10/2010)
6.	Dallapiccola, Bruno: 1 article (10/2010)
7.	Consoli, Federica: 1 article (10/2010)
8.	Sarkozy, Anna: 1 article (10/2010)
9.	Zhang, Ming-kui: 1 article (04/2009)
10.	Pan, Guang-yu: 1 article (04/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Crisscross Heart:

1.	Complete atrioventricular septal defectIBA 08/01/1993 - "Dextrocardia was found in 11 cases and mesocardia in 2. Situs inversus was demonstrated in 6 and levoisomerism in 4. Intracardiac and extracardiac shunts were diagnosed in 20 cases, Ebstein's anomaly in 27, corrected transposition of great vessels in 15, univentricular atrioventricular connection in 7, cor triatriatum in 1, parachute mitral valve in 1, crisscross heart in 1, and double-outlet left atrium in 1. TEE was of particular value in evaluating total anomalous pulmonary venous connection, common atrioventricular canal, Ebstein's anomaly, corrected transposition of great vessels, and univentricular atrioventricular connection and in diagnosis of the rarer congenital cardiopathies." 04/01/2009 - "Among them, 9 were univentricular and pulmonary artery valve stenosis; 3 were univentricular and pulmonary artery atresia; 1 was transposition of great arteries, crisscross heart and pulmonary artery valve stenosis; 1 was complete atrioventricular canal defects, left ventricular hypoplasia, pulmonary artery atresia and atrioventricular valvular regurgitation; 1 was complete atrioventricular canal defects, left ventricular hypoplasia, pulmonary artery valve stenosis and atrioventricular valvular regurgitation after Glenn procedure; 1 was mirror image dextrocardia, single ventricle, pulmonary artery atresia, major aortopulmonary collateral arteries (MAPCAs) and right pulmonary arteriovenous fistula after Glenn procedure; 4 were tricuspid atresia and pulmonary artery valve stenosis; 1 was tricuspid atresia and pulmonary atresia; 1 was mirror image dextrocardia, double-outlet of right ventricle, left ventricular hypoplasia, pulmonary artery valve stenosis, tricuspid incompetence, and MAPCAs. "
2.	Congenitally corrected transposition of the great arteriesIBA 11/12/2008 - "Criss cross heart in a congenitally corrected transposition of the great arteries." 07/01/1994 - "Diagnoses included double inlet left ventricle (n = 11), transposition of the great arteries with a large ventricular septal defect (n = 4), double outlet right ventricle (n = 2), congenitally corrected transposition of the great arteries with a large ventricular septal defect (n = 1) and criss-cross heart (n = 1). "
3.	Connexin 43 (Connexin43)IBA 10/08/2010 - "No pathogenic mutation was identified, suggesting that Cx43 mutations are not responsible for criss-cross heart in humans or are not a major cause for this defect." 10/08/2010 - "We screened the entire coding region of the Cx43 gene in a group of well characterized patients with criss-cross heart, to evaluate whether Cx43 gene mutations cause criss-cross heart in humans. " 10/08/2010 - "Exclusion of Cx43 gene mutation as a major cause of criss-cross heart anomaly in man."

Therapies and Procedures

1.	Fontan Procedure (Fontan Operation) 03/01/1983 - "Successful repair of criss-cross heart using modified Fontan operation." 03/01/2005 - "[Criss-cross heart: anesthetic considerations for total cavopulmonary shunt (Fontan procedure)]."
2.	Right Heart Bypass (Cavopulmonary Anastomosis) 01/01/1995 - "Indications for operation were the following: D(S)ILV = 16, TA = 9, MA = 3, TGA with straddling AV-valve = 2, DORV = 4 and criss-cross heart = 1. The same surgical technique was utilized in all patients with redirection of the systemic venous return by means of a bidirectional cavopulmonary anastomosis and an intraatrial baffle, adaptable to all the various forms of underlying anatomy. " 03/01/2005 - "[Criss-cross heart: anesthetic considerations for total cavopulmonary shunt (Fontan procedure)]."