Creosote

A greasy substance with a smoky odor and burned taste created by high temperature treatment of BEECH and other WOOD; COAL TAR; or resin of the CREOSOTE BUSH. It contains CRESOLS and POLYCYCLIC AROMATIC HYDROCARBONS which are CARCINOGENS. It has been widely used as wood preservative and in PESTICIDES and had former use medicinally in DISINFECTANTS; LAXATIVES; and DERMATOLOGIC AGENTS.

Also Known As:

Networked: 80 relevant articles (2 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Shibata, Takashi: 4 articles (01/2020 - 03/2003)
2.	Kuge, Tomoo: 4 articles (05/2007 - 03/2003)
3.	Clark, Bryan W: 3 articles (12/2014 - 09/2013)
4.	Di Giulio, Richard T: 3 articles (12/2014 - 08/2004)
5.	Ito, Masafumi: 2 articles (01/2020 - 12/2005)
6.	Miura, Takanori: 2 articles (01/2020 - 09/2012)
7.	Cooper, Ellen M: 2 articles (12/2014 - 09/2013)
8.	Stapleton, Heather M: 2 articles (12/2014 - 09/2013)
9.	Ataka, Koji: 2 articles (05/2007 - 12/2005)
10.	Willett, Michael S: 2 articles (10/2004 - 03/2003)

Related Diseases

1.	Diarrhea 02/28/2023 - "Wood creosote may not interact with these factors but ameliorates diarrhea symptoms." 05/30/2007 - "These results indicate that wood creosote prevents the increase in colonic motility induced by CRF via 5-HT(3) receptors in the proximal colon, and via 5-HT(4) receptors in the distal colon, suggesting that wood creosote might be useful to treat stress-induced diarrhea." 01/01/2001 - "However, wood creosote is still been listed in the Japanese Pharmacopoeia and is used for the treatment of diarrhea. " 07/24/2006 - "The results suggest that oral administration of wood creosote may prevent stress-induced diarrhea by preventing aversive effects on small intestinal secretion and barrier function." 10/01/2004 - "The aim of this study was to compare the efficacy and tolerability of wood creosote with those of loperamide hydrochloride in patients with acute, nonspecific diarrhea. "
2.	Vomiting 12/01/1847 - "Creosote in Vomiting." 05/01/2020 - "Goodsir recommended small doses of creosote as an antiseptic and claimed that the boy was eventually cured of the vomiting condition. " 10/01/2004 - "Patients aged >or=18 years with acute, nonspecific diarrhea, defined as a history of diarrhea for <or=72 hours and passage of >or=3 unformed stools in the 24 hours before the study, accompanied by >or=1 associated symptom (ie, nausea, vomiting, abdominal cramping, and/or fever [<or=101.0 degrees F or <or=38.3 degrees C]), were eligible for the study Patients received wood creosote 135 mg (<or=5 doses/d) or loperamide 4 mg (loading dose) followed by 2 mg (<or=8 mg/d) after each loose stool for <or=3 days. "
3.	Neoplasms (Cancer) 07/01/2005 - "Based on the present investigation and other studies, there was no evidence that employment at the 11 wood-treating plants or exposure to creosote-based wood preservatives was associated with any significant mortality increase from site-specific cancers or nonmalignant diseases. " 11/01/2016 - "Among 18 meta-analytic estimates by job or industry and type of neoplasm, 16 were close to unit, i.e., between 0.72 and 1.27, whereas the meta-RR was 1.38 [95 % confidence interval (CI) 0.95-2.01] for HL in foundry workers and 2.01 (95 % CI 0.96-4.22) for NHL in workers exposed to creosote. " 12/01/2006 - "Hershey Run is contaminated with creosote from an adjacent Superfund site, where sediments were frequently reported to have total PAH concentrations greater than 100 mg of total PAH/kg and a maximum of 13,300 mg/kg. No other locations had reports of total PAHs higher than 11 mg/kg. In conclusion, liver neoplasia was associated with exposure to sediment containing high concentrations of PAHs derived from creosote. " 01/01/2005 - "In this article, we review dermal and other malignancies associated with creosote, along with creosote occupational exposures and exposure limits. " 06/01/1999 - "Cancer warnings for creosote and bisphenol."
4.	Carcinogenesis 05/01/1940 - "Studies in carcinogenesis: XI. Development of skin tumors in mice painted with 3:4-benzpyrene and creosote oil fractions." 10/01/1985 - "The findings strongly suggest an association between exposure to creosote and the prevalence of hepatic lesions, including neoplasms, in the bottom-dwelling fish, and furthermore support the putative role of aromatic hydrocarbons in liver carcinogenesis in fish."
5.	Skin Neoplasms (Skin Cancer) 08/10/1999 - "A recent well designed skin painting study in mice clearly indicates that the creosote preparations had a five-fold higher potency to induce skin cancer than the potency based on BaP content. " 08/10/1999 - "Furthermore, it was estimated that creosote containing 50 ppm BaP would induce a significant incidence of skin cancer. " 02/01/1992 - "The findings indicate that impregnating wood with creosote in earlier decades increased the risk of skin cancer."

Related Drugs and Biologics

1.	Local Anti-Infective Agents (Antiseptics)
2.	Loperamide (Imodium)
3.	Coal Tar (Estar)
4.	Benzene (Benzole)
5.	Polychlorinated Biphenyls (PCBs)
6.	asphalt
7.	Soot
8.	Vinyl Chloride (Chloroethylene)
9.	Mustard Gas (Sulfur Mustard)
10.	Minerals

Related Therapies and Procedures

1.	Self Medication
2.	Oral Administration
3.	First Aid (Aids, First)