HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Cosyntropin (Cortrosyn)

Subscribe to New Research on Cosyntropin

A synthetic peptide that is identical to the 24-amino acid segment at the N-terminal of ADRENOCORTICOTROPIC HORMONE. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of CORTICOSTEROIDS in the ADRENAL CORTEX.

Also Known As:

Cortrosyn; Tetracosactide; 1-24-ACTH; 1-24-Corticotropin; ACTH 1-24; Corticotropin (1-24)-Peptide; Corticotropin (1-24)-Tetracosapeptide; Cortosyn; Organon Brand of Tetracosactide; Synthetic ACTH; Tetracosapeptide; ACTH, Synthetic; Tetracosactide Organon Brand; ACTH (1-24); Tetracosactrin; alpha1-24-Corticotropin

Networked: 320 relevant articles (13 outcomes, 24 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Arafah, Baha M: 4 articles (10/2012 - 04/2004)
2.	Moraes, Rafael Barberena: 3 articles (11/2013 - 01/2009)
3.	Friedman, Gilberto: 3 articles (11/2013 - 01/2009)
4.	Edwards, Stuart W: 3 articles (01/2013 - 11/2004)
5.	Osborne, John P: 3 articles (01/2013 - 11/2004)
6.	Findling, James W: 2 articles (01/2016 - 08/2008)
7.	Gan, Earn H: 2 articles (10/2015 - 01/2014)
8.	Auchus, Richard J: 2 articles (04/2015 - 06/2014)
9.	Hughes, Beverly A: 2 articles (01/2014 - 02/2012)
10.	Arlt, Wiebke: 2 articles (01/2014 - 02/2012)

Related Diseases

1.	Infantile Spasms (West Syndrome) 11/01/2001 - "The extremely low-dose synthetic ACTH therapy currently used in Japan is as effective for treatment of West syndrome as the higher doses reported in previous studies from Japan and Western countries. " 11/27/2015 - "The timing of initiation of tetracosactide therapy did not influence the outcomes of West syndrome therapy. " 12/15/1972 - "[Hypsarrhythmia and synthetic ACTH]." 04/01/1971 - "Treatment of hypsarrhythmia with synthetic ACTH." 05/01/1968 - "[Use of synthetic ACTH in hypsarrhythmia]."
2.	Adrenal Insufficiency (Adrenal Gland Hypofunction) 11/01/2012 - "Adrenal insufficiency was determined using a cosyntropin stimulation test in all studies. " 11/01/2001 - "Low doses of ACTH [1-24] (0.1, 0.5 and 1.0 microg per 1.73 m2) may provide a more physiological level of adrenal stimulation than the standard 250 microg test, but not all studies have concluded that the 1.0 microg is a more sensitive screening test for central hypoadrenalism. " 05/01/2013 - "The cosyntropin stimulation test is a very valuable test to assess the adrenal reserve but not to predict the risk of acute adrenal insufficiency. " 02/01/2012 - "Adrenal insufficiency is frequent, easily overlooked, but readily detected by cosyntropin testing." 02/01/2012 - "Short cosyntropin testing revealed adrenal insufficiency in 89%. "
3.	Asthma (Bronchial Asthma) 11/01/2006 - "The current authors carried out a systematic review and meta-analysis of placebo-controlled randomised dose-response studies of >or=4 weeks' duration, which assessed the adrenal effects of FP by cosyntropin stimulation tests in adult asthma. " 09/01/1986 - "Treatment with depot tetracosactrin may thus induce enhancement of skeletal maturation, but with the treatment regimen found to be efficacious in bronchial asthma, the effect is not very pronounced and does not perceptibly affect the ultimate outcome of growth." 08/01/1982 - "We conclude that a normal response to tetracosactrin does not indicate recovery of the HPA axis after stopping prolonged oral steroid therapy for asthma, and that patients should continue to carry steroid therapy cards for at least 5 years after such treatment has been discontinued." 05/01/1970 - "[Tetracosactide in the treatment of asthma]." 03/25/1974 - "[Hypersensitivity to synthetic ACTH (Synacthen) in patients with bronchial asthma]."
4.	Post-Dural Puncture Headache 01/01/2012 - "Cosyntropin has been reported to be effective in the treatment of post-dural puncture headaches, but there is a lack of data on its effectiveness. " 08/01/2010 - "Cosyntropin for prophylaxis against postdural puncture headache after accidental dural puncture." 01/01/2000 - "Use of intravenous cosyntropin in the treatment of postdural puncture headache." 01/01/2012 - "Caffeine was 80% (95% CI 60-100%) effective and cosyntropin was 56% (95% CI 33-79%) effective in treating post-dural puncture headaches. " 01/01/2012 - "We compared the efficacy of cosyntropin with that of caffeine in the treatment of post-dural puncture headaches. "
5.	Atopic Dermatitis (Atopic Eczema) 01/01/1984 - "The use of tetracosactide given intramuscularly allowed controlling the evolution of his atopic dermatitis. " 05/01/2010 - "This study adds hydrocortisone butyrate 0.1% cream, to the short list of corticosteroids that have been proven effective and safe by the cosyntropin suppression test in children 3 months and older with widespread atopic dermatitis."

Related Drugs and Biologics

1.	Hydrocortisone (Cortisol)
2.	Adrenocorticotropic Hormone (ACTH)
3.	Vigabatrin
4.	Adrenal Cortex Hormones (Corticosteroids)
5.	Hormones
6.	Caffeine (No Doz)
7.	Butyrates (Butyrate)
8.	Valproic Acid (Valproate, Semisodium)
9.	Melanocyte-Stimulating Hormones (MSH)
10.	Anticonvulsants (Antiepileptic Drugs)

Related Therapies and Procedures

1.	Epidural Blood Patch
2.	Intensive Care (Surgical Intensive Care)
3.	Critical Care
4.	Drug Therapy (Chemotherapy)
5.	Intravenous Injections