Corticotropin-Releasing Hormone

A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. CRH is synthesized by neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, CRH stimulates the release of ACTH from the PITUITARY GLAND. CRH can also be synthesized in other tissues, such as PLACENTA; ADRENAL MEDULLA; and TESTIS.

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Networked: 2046 relevant articles (37 outcomes, 190 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Theoharides, Theoharis C: 23 articles (10/2020 - 06/2003)
2.	Koob, George F: 20 articles (01/2022 - 10/2002)
3.	Holsboer, F: 14 articles (11/2015 - 01/2000)
4.	Chrousos, George P: 12 articles (01/2022 - 02/2002)
5.	Nemeroff, Charles B: 12 articles (01/2022 - 01/2002)
6.	Fukudo, Shin: 12 articles (07/2021 - 01/2007)
7.	Zorrilla, Eric P: 11 articles (01/2018 - 10/2002)
8.	Nozu, Tsukasa: 10 articles (04/2022 - 08/2006)
9.	Holsboer, Florian: 10 articles (01/2013 - 01/2004)
10.	Okumura, Toshikatsu: 9 articles (04/2022 - 12/2015)

Related Diseases

1.	Pituitary ACTH Hypersecretion 09/01/1995 - "The use of the corticotropin-releasing factor (CRF) stimulation test may be especially helpful in distinguishing Cushing's disease (CD) from major depression, though there is some degree of "overlap" in results. " 07/01/1989 - "The ovine corticotropin-releasing hormone (CRH) stimulation test is superior to the human CRH stimulation test for the diagnosis of Cushing's disease." 10/01/2022 - "The current gold standard diagnostic method for Cushing disease (CD) is bilateral inferior petrosal sinus sampling (BIPSS) after corticotropin-releasing hormone (CRH) stimulation. " 01/01/2018 - "Bilateral inferior petrosal sinus sampling (IPSS) with corticotropin-releasing hormone (CRH) is currently the gold standard in the diagnosis of Cushing's disease (CD) and has also been used in tumour lateralization. " 09/01/2013 - "Corticotropin-releasing hormone (CRH) loading test ruled out Cushing's disease and supported the diagnosis of EAS. "
2.	Cushing Syndrome 07/05/1984 - "These studies demonstrate that ectopic secretion of corticotropin-releasing factor is a cause of Cushing's syndrome in human beings. " 10/01/2019 - "Ectopic cushing's syndrome due to corticotropin releasing hormone." 01/01/2017 - "We examined whether this relative hypercortisolism is associated with alterations in the pituitary-adrenocortical response to evening corticotropin-releasing hormone (CRH) stimulation. " 06/01/2010 - "3 Tesla magnetic resonance imaging with and without corticotropin releasing hormone stimulation for the detection of microadenomas in Cushing's syndrome." 01/01/2007 - "[The value of corticotropin-releasing hormone (CRH) test for differential diagnosis of Cushing's syndrome]."
3.	Anxiety Disorders (Anxiety Disorder) 01/01/2009 - "The Sheehan Suicidality Tracking Scale was incorporated into a multicenter, randomized, double-blind, placebo-controlled, and active comparator study examining the efficacy of an experimental corticotropin-releasing factor antagonist (BMS-562086) for the treatment of generalized anxiety disorder. " 05/01/2010 - "Multicenter, randomized, double-blind, active comparator and placebo-controlled trial of a corticotropin-releasing factor receptor-1 antagonist in generalized anxiety disorder." 01/01/1993 - "The role of corticotropin-releasing factor in the pathophysiology of affective and anxiety disorders: laboratory and clinical studies." 12/01/2023 - "Although other signaling pathways are potentially involved in the process of anxiety, CRF in the PFC primarily modulates anxiety disorders through the activation of corticotropin-releasing factor type1 receptors (CRF-R1) and the excitation of the cAMP/PKA signaling pathway. " 02/15/2012 - "Faulty regulation of the central extrahypothalamic corticotropin-releasing factor (CRF) expression is associated with stress-related psychopathologies including anxiety disorders and depression. "
4.	Pain (Aches) 04/14/2010 - "Furthermore, pharmacologic inhibition (with a corticotropin-releasing factor 1 receptor antagonist) of pain-related hyperactivity in the basolateral amygdala (BLA), but not central amygdala (CeA), reversed deactivation of mPFC pyramidal cells and improved decision-making deficits. " 01/01/2024 - "Additionally, we study the implication of dynorphinergic and corticotropin releasing factor in these pain related behaviours. " 01/01/2021 - "Pharmacological studies have found that inhibiting corticotropin-releasing factor (CRF) signaling in the BNST can selectively mitigate the sensory and affective-motivational components of pain. " 01/01/2017 - "The current study examined the effects of SS on nociceptive behaviors and changes in expression of the spinal corticotropin-releasing factor (CRF) system in male Sprague Dawley rats with and without thermal pain. " 04/01/2006 - "This study examines the contribution of central corticotropin-releasing factor (CRF) to pain behavior. "
5.	Alcoholism (Alcohol Abuse) 01/01/2022 - "Corticotropin-releasing factor and its cognate type-1 receptor, a prominent brain stress system, is implicated in anxiety and alcohol use disorder (AUD). " 01/01/2018 - "One brain signaling system that has received much attention in animal models of excessive alcohol drinking and alcohol dependence is corticotropin-releasing factor (CRF). " 10/01/2017 - "Recent work has also identified an important role for the CeA corticotropin-releasing factor (CRF) system in the interaction between anxiety/stress and alcohol dependence. " 01/01/2017 - "The corticotropin-releasing factor (CRF) system plays a role in alcohol consumption, and its dysregulation can contribute to alcohol use disorder. " 01/01/2017 - "Alcohol dependence disrupts this LTCC-based mechanism; instead, corticotropin-releasing factor type 1 receptors (CRF1s) mediate alcohol's effects on CeA activity and drive the escalated alcohol intake of alcohol-dependent rats. "

Related Drugs and Biologics

1.	Adrenocorticotropic Hormone (ACTH)
2.	Dexamethasone (Maxidex)
3.	Hydrocortisone (Cortisol)
4.	Neuropeptides
5.	Corticotropin-Releasing Hormone Receptors (Corticotropin Releasing-Hormone Receptor)
6.	Peptides (Polypeptides)
7.	Urocortins
8.	Neurotransmitter Agents (Neurotransmitter)
9.	Antidepressive Agents (Antidepressants)
10.	Hormones (Hormone)

Related Therapies and Procedures

1.	Therapeutics
2.	Adrenalectomy
3.	Injections
4.	Self Administration (Administration, Self)
5.	Blepharoplasty