Corticosterone

An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)

Also Known As:

Networked: 2996 relevant articles (67 outcomes, 244 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Raff, Hershel: 15 articles (08/2014 - 01/2003)
2.	Tufik, Sergio: 12 articles (11/2015 - 01/2007)
3.	Vranic, Mladen: 11 articles (07/2013 - 06/2002)
4.	Zohar, Joseph: 10 articles (02/2015 - 12/2007)
5.	Cohen, Hagit: 10 articles (02/2015 - 12/2007)
6.	Kaplan, Zeev: 10 articles (02/2015 - 12/2007)
7.	Bruder, Eric D: 10 articles (08/2014 - 05/2004)
8.	Bagaeva, T R: 10 articles (01/2014 - 09/2003)
9.	Chan, Owen: 10 articles (10/2008 - 06/2002)
10.	Riddell, Michael C: 9 articles (05/2015 - 12/2004)

Related Diseases

1.	Shock 06/22/1999 - "Plasma corticosterone levels in response to avoidable foot shock in the LH- rats were significantly greater than in the LH+ group. " 01/01/2015 - "To further examine the efficacy of corticosterone in treating hyperarousal and elevated fear, the present study utilized a learned helplessness stress model in which rats are restrained and subjected to tail shock for three days. " 07/01/2012 - "This study investigated whether neuronal modulation was induced in the amygdala after two kinds of stress, that is, such as electric shock and corticosterone injection. " 07/01/2003 - "Furthermore, exogenously applied corticosterone or foot shock stress before water maze training prevented the impairment of memory retrieval that should be induced by treatment with corticosterone or foot shock before the 'probe trial'. " 07/01/1992 - "The present study was designed to determine the role of corticosterone induction by Rs-DPLA and its effect on TNF regulation and survival in lethal endotoxin shock models and to evaluate the ability of Rs-DPLA to induce endotoxin tolerance. "
2.	Neoplasms (Cancer) 03/01/2013 - "However, only the AWA protocol was effective in predicting the tumor size and the level of fecal corticosterone metabolites (FCM). " 07/01/2003 - "Whereas the effects of exogenously administered corticosterone and ER had many similarities, the lower efficacy of corticosterone versus ER in inhibiting the carcinogenic process imply that changes in cortical steroid metabolism alone are unlikely to explain the cancer inhibitory activity of ER." 12/14/2009 - "This study confirms that social stress has complex effects on immune system and tumor development that are not simply linked to corticosterone titers." 11/01/2008 - "In a lifespan study, female rats lived with their sisters and were tested for temperament, affiliative reciprocity during an everyday stressor at puberty, corticosterone response to a stressor, mammary tumor development and diagnosis, and death. " 10/20/2008 - "This study analyzed in Balb/C mice the effects of individual housing on behavior, serum corticosterone and resistance to Ehrlich tumor growth. "
3.	Body Weight (Weight, Body) 08/01/1991 - "The optimal dose of corticosterone (30 mg/kg of feed) was effective in maintaining postchallenge-exposure body weight greater than that of controls. " 01/01/2015 - "The relative efficacy of pre versus post administration of corticosterone and high versus low dose of corticosterone on stress-induced exaggeration of innate fear response and stress-retarded body weight growth indicate that exogenous corticosterone administration within an appropriate time window and dosage are efficacious in diminishing traumatic stress induced pathophysiological processes. " 01/17/2014 - "Exposure to chronic scream sound suppressed body weight gain, increased corticosterone (CORT) level, influenced the morphology of adrenal gland, improved spleen and thymus indices, and decreased latency in MWM test. " 01/01/2013 - "The present study uses a TCPL drug delivery system to administer corticosterone (CS) continuously in male and female animals for 24 days and evaluates long term chronic use effects on body weight, adrenal weight, and adrenal ultrastructure. " 03/17/2012 - "In the present study, we examined the extent of the effects of PSD for 72h on spatial learning and memory, anxiety-like behavior, corticosterone levels, and the body weight in male as well as in intact and ovariectomized (OVX) female Wistar rats. "
4.	Inflammation 01/01/1993 - "We found no change of the plasma corticosterone level in 6-SAI-dosed animals, neither at the beginning of 6-SAI administration nor when the inflammation reached maximal values nor during the remission of paw swelling. " 01/30/2006 - "Few studies, however, have examined whether altered corticosterone production is actually associated with changes in systemic inflammation in the neonatally endotoxin challenged adult animal. " 09/01/2000 - "The hypothesis of this study was that food intake and diurnal corticosterone analysis can be used as indicators of adjuvant-induced TMJ inflammation. " 01/01/2016 - "Anxiety- and depression-like behaviors, HPA-axis-reactivity (corticosterone), and hippocampal inflammation (TNF-α and IL-1β) after exposure to stress were evaluated. " 09/21/2015 - "Intestinal ACE shedding is increased by DSS-induced intestinal inflammation and parallels local corticosterone production. "
5.	Seizures (Seizure) 02/01/2006 - "The purpose of this study was to determine the role of corticosterone (CORT) in the detrimental effects of neonatal isolation (NI) on seizures. " 04/01/2014 - "In adult female rats subjected to MS from postnatal days 2-14, seizure-induced corticosterone responses were significantly augmented and prolonged for at least two hours post-seizure, compared to control early-handled (EH) rats. " 04/01/2014 - "Here, we tested whether hypothalamic-pituitary-adrenal (HPA) axis hyper-reactivity induced by MS - specifically the excessive secretion of corticosterone following a seizure - was involved in this vulnerability. " 01/01/2014 - "We saw that the baseline frequency of SWDs in Scn8a mutants correlates closely with the diurnal activity of the hypothalamic-pituitary-adrenal (HPA) axis, with a peak in seizure activity occurring at around the same time as the peak in corticosterone (1700-1900h). " 01/01/2011 - "Here we tested the hypotheses that MS would augment seizure-related corticosterone (CORT) release and enhance neuroplastic changes in the hippocampus. "

Related Drugs and Biologics

1.	Adrenocorticotropic Hormone (ACTH)
2.	Insulin (Novolin)
3.	Dexamethasone (Maxidex)
4.	Interleukin-6 (Interleukin 6)
5.	Glucose (Dextrose)
6.	Glucocorticoids
7.	Aldosterone
8.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
9.	Cytokines
10.	Metyrapone

Related Therapies and Procedures

1.	Adrenalectomy
2.	Transplantation (Transplant Recipients)
3.	Resuscitation
4.	Injections
5.	Analgesia